Hyderabad

Applications invited for Research Specialist position, sponsored by the National Institute of Animal Biotechnology at University of Hyderabad | Require M.Sc / IM.Sc / M.Tech / M.Pharm

Applications are invited from qualified individuals for Research Specialist position, sponsored by the National Institute of Animal Biotechnology (NIAB-DBT) project entitled “Studies on epigenetic regulation during lactation and its impact on milk biosynthesis” (NIAB/CP/107/2012).

Post: Senior Research Fellow

ENHANCEMENT OF DISSOLUTION OF POORLY WATER SOLUBLE DRUG USING SUPER DISINTEGRANTS BY KNEADING METHOD

About Authors:
YASWANTH ALLAMNENI1*, PAVAN POTTURI1, RAJKUMAR NULU2, RAVADA RAMESH3, P DAYANANDA CHARY1, ARUN KALEKAR1.
1Research and Development Department, Natco Pharma Limited, Kothur, Mahaboobnagar,Andhra Pradesh, India-509228.
2Research and Development Department, Aurobindo Pharma Ltd., Hyderabad, Andhra Pradesh, India.
3HOD, Dept. of Pharmaceutics, Dr. H.L.T. College of pharmacy, Kengal, Channapatna, Banglore(R).

*yaswanthallamneni@gmail.com

ABSTRACT
The aim of this study was to investigate the influence of superdisintegrants on the dissolution properties of a poorly water-soluble drug from complexes prepared by kneading method. Ketoprofen was employed as a model drug. Solid dispersions prepared by kneading method exhibited higher dissolution rate and DE30 values in each case. Ketoprofen tablets were prepared by direct compression technique using microcrystalline cellulose as a directly compressible vehicle. The formulated tablets were evaluated by different In Process Quality Control tests, content uniformity and in vitro drug release study. The FTIR spectra’s study revealed that there were no interaction between polymers and drug. All the tablets formulated employing solid dispersions in superdisintegrants gave rapid and higher dissolution of Ketoprofen when compared to that of Ketoprofen plain tablets. Ketoprofen dissolution from all the tablets followed first order kinetic with correlation coefficient ‘r’ above 0.9470. All dissolution parameters (k1, DE30 and T30) indicated rapid and higher dissolution of Ketoprofen from tablets formulated employing its solid dispersions in superdisintegrants when compared to plain tablets.

Vacancy for Director at NIPER Rae Bareli, Hajipur, Guwahati, Kolkata, Ahemedabad and Hyderabad

Government of India has set up six new National Institutes of Pharmaceutical Education and Research (NIPERs) under the aegis of Ministry of Chemicals and Fertilizers, Department of Pharmaceuticals, at Rae Bareli, Hajipur, Guwahati, Kolkata, Ahmedabad and Hyderabad. These are presently being run with the help of Mentor Institutes. The Institutes are required to be established on their own.

Opening for Junior Manager - Sterile Manufacturing at Dr. Reddy's Laboratories - 15 posts

Dr. Reddy's Laboratories (NYSE: RDY) is an emerging global pharmaceutical company with proven research capabilities. The company is vertically integrated with a presence across the pharmaceutical value chain. It produces finished dosage forms, active pharmaceutical ingredients and biotechnology products and markets them globally, with focus on India, US, Europe and Russia.

Opportunity for M.Pharm & M.Sc to join in National Institute of Nutrition as SRF through Walk in Interview

National Institute of Nutrition (NIN) was founded by Sir Robert McCarrison in the year 1918 as ‘Beri-Beri’ Enquiry Unit in a single room laboratory at the Pasteur Institute, Coonoor, Tamil Nadu. Within a short span of seven years, this unit blossomed into a "Deficiency Disease Enquiry" and later in 1928, emerged as full-fledged "Nutrition Research Laboratories" (NRL) with Dr.

Pages

RECOMMENDED JOBS