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  • FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF NIFEDIPINE

    About Authors:
    *DINESH BABU GOTTIPATI1, SREE DEVI ANANDHAM1, NANNAPANENI VENKATA BALAKRISHNA RAO2.
    1 Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
    2 Research and Development Department, Natco Pharma Limited, Kothur.
    *babu.dinesh89@live.in

    ABSTRACT:
    The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm2, wetting time of 31sec   and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

  • A Client of Aple Pharma require Medical Representative & Area Manager | Multiplace Vacancies

    A leading Pharmaceutical Company requires Medical Representative at all the major HQ's in India.

    Post: Medical Representative & Area manager

  • Sami Labs invites Executive - Regulatory Affairs

    To facilitate the increased demand for innovative application-based products, Sami Labs Limited (formerly known as Sami Chemicals & Extracts Limited) was set up in 1991 at Singasandra in Bangalore ( India ) as a research and development facility. Today the main thrust and focus of Sami is on new product development and market oriented research.

  • Must Read Article: PHARMA, JOURNEY TO……. JAIL

    About Author:
    Mr. Jagmohan Rai Agarwal,
    M.Pharm (1968), Industrial experience SSI sector, nearly 37 years, retired from own Industry,
    Founder President of M.P.Pharmacy Graduates’ Association,
    President: M.P.Pharmaceutical Manufacturers’ Organisation,
    Founder President : M.P. Small Scale Drug Manufacturers’ Association,
    President Indian Pharmaceutical Association, M.P. State Branch, Indore,
    Recently submitted thesis for award of  Ph.D. on title “Enforcement of Drug Laws-Globalization vis-à-vis Indian Drug Laws”
    (Email: sharda_jollo@yahoo.co.in)

    Quality of Pharmaceuticals has been a concern of the World Health Organisation (WHO) since its inception. The setting of global standards is requested in Article 2 of the WHO constitution which sites as one of the organisation’s functions that it should develop, establish and promote International standards with respect to food, biological, pharmaceuticals and similar products.

    Campbell (US FDA) was the first leading architect of the present Federal Food, Drug and Cosmetics Act passed in 1938. He differed sharply with ‘Willey’ in his belief that Court proceedings were not the only proper way to secure compliance.

  • Job as Clinical Research Associate in PPD Pharma | Mumbai / Bangalore / New Delhi

  • PREVENTION OF NOSOCOMIAL INFECTIONS

    About Authors:
    *1P.SanilKumar, 1C K. Dhanapal, 2Sandhya Ravi
    1Department of Pharmacy,
    Annamali University, AnnamaliNager,
    Chidambaram, Tamilnadu.
    2Lotus Labs Pvt Ltd,
    No.07, Jasmabhavan Road, Vasanthanager, Bangalore, Karnataka.

    *sanilmpharm@gmail.com

    ABSTRACT
    Hospitals are created for cure the disease but not for the spreading of diseases, even though this statement is true to the theoretical concept but it is not possible practically due to various risk factors. The spread of infection in the hospitals occurs due to the microorganism. Nosocomial infections add significantly to the economic burden of managing the underlying disease that has lead to hospitalization of the patient. More than 90% of reported infections are bacterial where as viral, fungal or protozoal infections are less commonly involved in hospital-acquired infections. This project deals with bacterial nosocomial pathogens only, since they are by far major causes of nosocomial infections. Objective of the present study include  the identification, prevention and control of nosocomial infection in our hospitals. The ultimate aim is the reduction of nosocomial infections and their costs. Baseline study for morbidity pattern in the hospitals, finding sources of exogenous and endogenous sources of nosocomial infection. Suggest measures to minimize the nosocomial infections and suggest guidelines for efficacious management of nosocomial infections.

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  • Job in Biocon as Clinical Asst. Manager

  • Freshers invited for walk in interview for production in Cipla - 6 posts

    Cipla known for its innovative pharmaceutical products backed by latest in technology and creative marketing practices, is enjoying a commanding position among the top pharma companies in the country.
    Several specialised therapeutic divisions and promising new products have been launched and many more are in the pipeline.

  • Walk in : Job as Sales Officers, District Managers, Regional Sales Manager, Sales Manager in Ajanta Pharma

    Ajanta Pharma Limited is an emerging, global pharmaceutical company with proven capabilities in the areas of product research, manufacturing & marketing.

  • Job as Senior Research Associate in Syngene International

    Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area.

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