About Author: D. Gopi Krishna
M.Phil
Tirumala Engineering College
Hyderabad, Andhra Pradesh

ABSTRACT:
Antibiotics are one of the most important commercially exploited secondary metabolites produced by the bacteria and employed in a wide range. Most of the antibiotic producers used today are the soil microbes. Fungal strains and streptomyces members are extensively used in industrial antibiotic production. Bacteria are easy to isolate, culture, maintain and to improve their strains. Microbes are omni present and exist in a competitive environment. Bacillus species being the predominant soil bacteria because of their resistant endospore formation and production of vital antibiotics like bacitracin etc. are always found inhibiting the growth of the other organisms. In the present project a soil bacterium with the antibiotic activity is screened studied for morphological  characters which can provide valuable information about the strain. The inhibitory activity of the organism is checked against some of the important opportunistic microbial flora and inoculated into an appropriate designed media depending on the bacterial requirements, and incubated for 48 hrs at 370C.  The produced compound is extracted by solvent extraction and assayed for its activity. Enhancement in the antibiotic production is studied under various parameters like temperature, pH, carbon source concentration, and Sodium nitrate concentration, which may help in the industrial production. The extracted substance was found effective against the gram positive endospore forming bacilli and gram positive coci. Though a large list of antibiotics are commercially available, the search for the most potential one is still on, and this work may provide some potential information on the antibiotic production and the control of microbial strains.

Objective: The objective of the present study is production extraction and assay of   antibiotics from bacterial and fungal isolates using soil as source.

About Author: Shekh Yunus1, Nirmal Das Adhikary2 and Partha Chattopadhyay*
National Institute of Pharmaceutical Education and Research
at IICB, Jadavpur, 4 Raja S.C. Mullick Road, Kolkata-700032, India

Source of Support: NIPER Kolkata and IICB

ABSTRACT:
Click chemistry is a modular approach that uses only the most practical and reliable chemical transformations. Its applications are increasingly found in all aspects of drug discovery, ranging from lead finding through combinatorial chemistry and target-templated in situ chemistry, to proteomics and DNA research, using bioconjugation reactions. The copper-(I)-catalyzed 1,2,3-triazole formation from azides and terminal acetylenes is a particularly powerful linking reaction, due to its high degree of dependability, complete specificity, and the bio-compatibility of the reactants. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen bonding and dipole interactions.

About Authors: Shanker Swaroop Sharma
B.Pharm
Sagar Institute of Tech. & Management, Barabanki

ABSTRACT:
With enormous increase in the population the demand of pesticides gradually increases throughout the world. the question arises that where the fault begins, whether farmers are spraying overdose of pesticides either to earn money or to save their crop. Movement of pesticides into surface or ground water affected human & wildlife beyond acceptable safety levels where 20000 deaths reported annually.

About Authors:Kisananad Vishwakarma,
B.Pharm
SGI Barabanki,
GBTU

ABSTRACT:
Pharmacogenetics is generally regarded as the study or clinical testing of genetic variation that gives rise to differing response to drugs. It refers to genetic differences in metabolic pathways which can affect individual responses to drugs. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in, drug metabolism with a particular emphasis on improving drug safety. The wider use of pharmacogenetic testing is viewed by many as an outstanding opportunity to improve prescribing safety and efficacy.

Krishna University largely caters to the higher educational needs of people in Krishna District in particular and Andhra Pradesh in general. Krishna district was one of the oldest British administered areas of Andhra Pradesh. It was formerly called Masulapatnam district, and in1859 when the then Guntur district was delinked, certain taluks, there of, were added to this, which was renamed as Krishna district, after the mighty river Krishna.

Bal Pharma Limited.,a Rs.100 crore Pharmaceutical company is among the pioneer pharmaceutical companies that strive on innovation & research and is acknowledged globally.  Bal Pharma is looking for self driven and result oriented professionals for the following positions at the corporate office in Bangalore.

Institute of Nuclear Medicine and Allied Sciences (INMAS), Delhi under the aegis of Defence Research and Development Organisation (DRDO), is engaged in research and developmental work in the areas of radiation biosciences and non-invasive imaging.

Established in the year 1978 as an exclusive facility for Small Volume Parenterals (SVPs), Gland Pharma has developed into a progressive and quality conscious organization serving the pharmaceutical needs of diverse markets across the globe.
The Company has world-class & world-scale facilities for injectables set up in collaboration with Vetter Group, Germany. The collaboration with Vetter provides Gland Pharma a technological edge in injectables and specifically in Pre Filled Syringes.

A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Since its inception in 1985, accepting challenges and ensuring customer delight has been the hallmark of Ratnamani. In just two decade, Ratnamani has grown to become a multi-product, multi location public limited company providing total piping solutions to a diverse range of industries.

SIRO Clinpharm is one of the leading Global Clinical Research Organizations (CROs), offering full scope services conducting clinical trials in the Pharmaceutical, Biotechnology and Medical Devices sectors in compliance with International Standards. We are headquartered in India having global presence in USA, Israel and in Europe at Germany, Czech Republic, Greece, Estonia, Romania, Spain and France.

SIRO Clinpharm is one of the leading Global Clinical Research Organizations (CROs), offering full scope services conducting clinical trials in the Pharmaceutical, Biotechnology and Medical Devices sectors in compliance with International Standards. We are headquartered in India having global presence in USA, Israel and in Europe at Germany, Czech Republic, Greece, Estonia, Romania, Spain and France.

Unique group is most progressive and fast growing Pharmaceutical Company with Diverse interest in domestic formulation, exports & bulk drugs with modern manufacturing facilities. Our Formulation & bulk drug plants are approved by US FDA and TGA Australia . We also hold valid patents in US and other countries. We are looking for result oriented & committed professionals for our Manufacturing facilities located in Ankleshwar/Panoli.

BIT, Mesra is a "Deemed University" under Sec. 3 of the U.G.C. Act 1956.

BHARAT INSTITUTE OF PHARMACY'S MISSION IS TO IMPART HIGH QUALITY EDUCATION TO LOCAL AND RURAL STUDENTS IN THE FIELD OF ENGINEERING & TECHNOLOGY AND TO CONDUCT ADVANCED RESEARCH PROGRAMS BY FOSTERING CLOSE PARTNERSHIP WITH R&D INSTITUTIONS AND INDUSTRY.