A Simple spectrophotometric estimation of ceftriaxone sodium in bulk and sterile formulation
PharmaTutor (September- 2015)
Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 9)
Received On: 18/04/2015; Accepted On: 28/04/2015; Published On: 01/09/2015
AUTHORS: M. Jambulingam*, S. Ananda Thangathurai, D. Kamalakannan, S. Punitha, Rincy T.R, S. Santhi1, G. Surya, M. Vasanthi., S. Josephine Subarla.
Department of Pharmaceutical Analysis, Swamy Vivekanandha College of Pharmacy,
Elayampalayam-637205, TN, India
ABSTRACT: A simple spectrometric method has been developed for the estimation of the ceftriaxone sodium in powder for injection dosage form by derivatization with p-dimethyl amino benzaldehyde. The measurement of absorbance and derivatized ceftriaxone sodium at 490.4nm. The both methods obeys Beer’s and Lambert’s law in the range of 5-25µg/ml with the correlation co-efficient of r²0.998. The colour reaction was highly stable and didn’t show any changes in absorbance up to 48hrs. The % RSD associated with all the validation parameter was less than 2, showing the accuracy of the method developed. The compliance of acceptance criteria of Q2 (R1), (R2) international conference on harmonization (2005 guidelines).
How to cite this article: M Jambulingam, SA Thangathurai, D Kamalakannan, S Punitha, TR Rincy, S Santhi, G Surya, M Vasanthi, SJ Subarla; A Simple spectrophotometric estimation of ceftriaxone sodium in bulk and sterile formulation; PharmaTutor; 2015; 3(9); 48-52