Spectrophotometric Methods for The Determination of Nitaoxanide in Bulk Drug and its Pharmaceutical Formulation

  • Posted on: 1 November 2014
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PharmaTutor (November- 2014)

 

ISSN: 2347 - 7881
(Volume 2, Issue 11)

 

Received On: 26/09/2014; Accepted On: 30/09/2014; Published On: 01/11/2014

 

AUTHORS: R.Meera1*, N.Swathylakshmi2, M.Sundarapandian2, P.Raja Soundara Pandian1, Madhavanmallayasamy1
1Researcher, Radianz Health Care Pvt Ltd, Madurai, Tamilnadu, India
2Department of pharmaceutical chemistry, K.M.College of pharmacy, Uthangudi, Madurai, India
meeraharsa23@gmail.com

 

ABSTRACT:
Objectives:
A simple spectrophotometric method was developed and validated for the determination of Nitaoxanide in pharmaceutical dosage forms. Two visible spectrophotometric methods have been described for the assay of Nitaoxanide bulk form or dosage forms.
Methods: Method A is based on the formation of Schiff’s base and it was condensed with 4 hydroxybenzaldehyde. Method B is based on diazotization and coupling method with phluroglucinol. The methods are done in UV Visible spectrophotometric method having maximum absorbance at 460 nm.
Results: Regression analysis of Beers law plots showed good concentration range of 10-50µg/ml for method A and B and gives reproducible results.
Conclusion: Due to its simplicity of the method it may be used for determining Nitaoxanide in bulk and dosage forms.

 

How to cite this article: R Meera, N Swathylakshmi, MS Pandian, PRS Pandian, M Mallayasamy; Spectrophotometric Methods for the Determination of Nitaoxanide in Bulk Drug and its Pharmaceutical Formulation; PharmaTutor; 2014; 2(11); 120-127

 

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