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Difference spectrophotometric estimation of Capecitabine from tablet dosage form


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March 2016 ARTICLE LIST >>

PharmaTutor (March- 2016)


Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 4, Issue 3)


Received On: 16/09/2015; Accepted On: 29/09/2015; Published On: 01/03/2016


Rohit A. Patil*, Rajendra C. Doijad, Pravin D.Lade, Pournima S. Sankpal
Department of Pharmaceutical Chemistry,
Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India


ABSTRACT: Simple, sensitive and specific spectrophotometric method were developed and validated for quantification of CAPECITABINE (CAP) by difference spectroscopy. CAP exhibits a substantial difference in absorbance in the two solvents that is in 0.01 N HCL and 0.01 N NAOH at 295 nm. Beer’s law was obeyed in the concentration range of 1 to 20 μg ml-1for CAP. Results of tablet analysis showed standard deviation in the range of 98.42 to 101.95 % for CAP which indicate repeatability of the method. The results indicated excellent recoveries ranging from 98.45 to 101.70 % for CAP with a mean of 99.12 %. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in the tablet formulation indicating accuracy and reliability of the method.


How to cite this article: Patil RA, Doijad RC, Lade PD, Sankpal PS; Difference spectrophotometric estimation of Capecitabine from tablet dosage form; PharmaTutor; 2016; 4(3); 17-21