Hepatoprotective activity of glimepiride by inducing CCl4 hepatotoxicity

  • Posted on: 31 July 2016
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PharmaTutor (August - 2016)


Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 4, Issue 8)


Received On: 18/02/2016; Accepted On: 13/03/2016; Published On: 01/08/2016


C.V.H.Hemavathy*, B. Raj kumar, R. Kiran kumar, G. Hema latha
Faculty of Pharmacy,
Kottam Institute of Pharmacy, Erravally X Roads, Mahaboob Nagar, India


ABSTRACT: To evaluate the mechanism of hepatoprotection in terms of Liver antioxidant mechanism, histopathological study, the animals were divided into Four groups of three animals each. Except the normal group all the other groups received CCl4 in at a dose of 0.1 ml/kg by intraperitoneally for 14 days. Normal groups received plain tween 80 orally. On the 14th day all the rats from all the groups were sacrificed, blood was collected from each animal for serum analysis and their livers were stored under freezing conditions for the estimation of endogenous anti oxidants and one sample from each group was stored in 10% formalin for histopathological studies. In bio-chemical studies- Serum analytical methods (AST), (ALT), (Alk.P), (Bil), (TP), (TC). The present findings observed in this study revealed that, glimepiride is natural antioxidant lignin possess significant antioxidant activity against CCl4 induced hepatotoxicity via antioxidant mechanism. However, further research is required to find out the other possible mechanism of hepatoprotection to conform that as glimepiride hepatoprotective molecule.


How to cite this article: Hemavathy CVH, Kumar BR, Kumar RK, latha GH; Hepatoprotective activity of glimepiride by inducing CCl4 hepatotoxicity; PharmaTutor; 2016; 4(8); 42-48