GATE PY – 1992 Question Paper

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1.20. Infected blood products may produce serum hepatitis due to the presence of
(a) Hepatitis A virus (b) Hepatitis B virus
(c) Hepatitis C virus (d) None of the above

1.21. pH of a buffer system can be calculated by using
(a) pH partition theory (b) Noyes-Whilney law
(c) Henderson-Hasselbalch equation (d) None of the above

1.22. Osmolality measures the total number of particles dissolved in a _______ of
water and depends on the electrolytic nature of the solute.
(a) kilogram (b) kilolitre (c) litre
(d) specified quantity

1.23. Ergot is the sclerotium of
(a) fungus Claviceps purpurea (b) fungus Claviceps notatum
(c) Strychnos nuxpotatorum (d) fungus Pencillium chrysogenum

1.24. A highly sensitive semiquantitative method of detecting microbial antigen in biological fluid is done by
(a) Radioimmunoelectrophoresis (b) counterimmunoelectrophoresis
(c) H.P.L.C (d) Freeze dried centrifugal method

1.25 The glass electrode used in pH measurements is
(a) metal-metaloxide electrode (b) a membrane electrode
(c) ion selective electrode (d) none of the above

1.26 In phenonthiazine tranquillizing agents, replacement of C-2 hydrogen by chlorine
(a) decreases activity (b) increases activity
(c) activity unaffected
(d) leads to decreased penetration into the CNS

1.27 The loading dose of a drug is based upon the
(a) time taken for complete elimination
(b) percentage of drug excreted unchanged in urine
(c) percentage of drug bound to plasma protein
(d) apparent volume of distribution and the desired drug concentration in plasma

1.28 Conformation of drugs is commonly determined by
(a) NMR (b) NMI (c) Mass spectrometry
(d) pH determination

1.29 Aminophylline solutions on exposure to air may develop
(a) crystals of theophylline (b) precipitate of aminophylline
(c) precipitate of ethylenediamine (d) straw colour

1.30 The hypotensive effect of clonidine is due to its action on
(a) ß -adrenergic receptor (b) a -adrenergic receptor
(c) H -receptor (d) H œreceptor

1.31 A step in Vitamin A synthesis is
The product obtained will be
(a) 3-hydroxy-3-methyl-1-pentene-4-yne
(b) hex-1-yn-5-one
(c) 3-amino-3-methyl-1-pentene-4-yne
(d) none of the above

1.32 Sodium nitroprusside is one of the most potent blood-pressure lowering drugs. Its use is limited because of
(a) its short duration of action (b) very long duration of action
(c) ineffective of oral route (d) none of the above

1.33 Cocaine is a monoacid tertiary base which on treatment with hot dilute acids gives
(a) ecogonine, methyl alcohol and scopic acid
(b) ecogonine, methyl alcohol and cinnamic acid
(c) ecogonine, methyl alcohol and benzoic acid
(d) ecogonine, ethyl alcohol and benzoic acid

1.34 Use of Isoniazid is restricted due to
(a) Ototoxicity (b) Hepatotoxicity
(c) Neutrotoxicity (d) Bone marrow depression

1.35 Diosgenin is
(a) an alkaloid obtained from dioscorea
(b) a carbohydrate obtained from disscorea
(c) a glycoside obtained from dioscorea
(d) none of the above

1.36 The IUPAC nomenclature of the sulindac analogue is:
(a) (Z)-5-Fluoro-2-methyl-1-phenylmethylene-1 H-indene-3-acetic acid
(b) (E)-5-Fluoro-2-methyl-1-phenylmethylene-1 H-indene-3-acetic acid
(c) 5-Fluoro-2-methyl-1-phenylmethylene-1 H-indene-3-acetic acid
(d) (R)-5-Fluoro-2-methyl-1-phenylmethylene-1 H-indene-3-acetic acid

1.37 Bubble point test is done to determine
(a) the surface tension of the liquid in capillary tubes
(b) the viscosity of the liquid in ampoules
(c) the pH of a 1% solution
(d) the volume of the solution stored in a specified container

1.38 The —Hemiacetal“ form of aldosterone is between
(a) C-11, ß -hydroxyl and C-20 carbonyl
(b) C-11, ß -hydroxyl and C-21 hydroxy
(c) C-11, ß -hydroxy and C-18 carbonyl
(d) C-21, ß -hydroxyl and C-20 carbonyl

1.39 Surfactants are characterized by the presence of
(a) water solubilizing and fat solubilizing groups in the same molecule
(b) only negative charges
(c) only positive charges
(d) none of the above

1.40 Acetous perchloric acid solution a common titrant in non-aqueous titrimetry is standardized by
(a) standard alcoholic KOH solution
(b) N/10 Potassium permanganate
(c) Potassium hydrogen phthalate solution in glacial acetic acid
(d) mercuric acetate in glacial acetic acid

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