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Recruitment for Scientists at Syngene International | M.Pharm, M.Sc apply

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Recruitment for Scientists at Syngene International Ltd

Incorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene’ s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.

Posts: Associate Scientist - DMPK In vivo Pharmacokinetics, Associate Scientist Bioanalytical, Senior Associate Scientist -Invitro ADME Bioanalyst

Associate Scientist - DMPK In vivo Pharmacokinetics (36343)
Job Description
The candidate will be a part of the Discovery Biology-DMPK group, looking for a candidate who is well versed with In vivo pharmacokinetics & to conduct study in rodents. Ability to adapt to the dynamic team environment.
• Conduct of pharmacokinetic studies in rodents.
• Preparation of study protocols, reports for IND/ NDA submissions.
• Documenting the lab notebooks online and compound management.
• Ability to adapt to the dynamic team environment.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’ s  data integrity policies
• Compliance to Syngene’ s quality standards at all times.

Candidate Profile
• MPharm
• Well versed with surgical procedures like cannulation of jugular, femoral, portal vein in rats. Chronic bile duct cannulations in rat and various animal models used for in vivo pharmacokinetics studies.
• Collection of different vital organs during tissue distribution studies in rodents
• Pharmacokinetic data analysis using Phoenix WinNonlin and other data analysis tool.
• Collection of various biological fluids like cerebrospinal fluid, bile, urine, synovial fluid lavage during PK and tissue distribution studies in rodents.
• Should have preliminary understanding about formulations to be used for pharmacokinetics, efficacy and toxicity studies.
• Knowledge about regulatory guidelines followed for drug metabolism and pharmacokinetics is desirable.
• 3-6 years post qualification
• Should be well versed in verbal and written communication, should be a team player.
• Should be focused towards results and deliverables.
• Should have a high moral framework (ethics code) and high data integrity sense.


Associate Scientist - DMPK Bioanalytical (30621)
Job Description
- Plan and supervise routine Bioanalytical work-flow to ensure deliverables/ productivity, along with verification of analytical study data for its accuracy and integrity.
- Mentor and supervise fellow scientists for method development and troubleshooting for routine as well as critical Bioanalytical work.
- The candidate will be responsible for providing input into the design of experimental protocols and Bioanalytical procedures for the analysis of drug candidates in biological sample.
- Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene.
- Adherence to all environment, health, and safety (EHS) policies & standards at all times in the work place.
- Wearing all PPE as required.
- Adherence to all procedures related to Syngene’ s data integrity policies
- Compliance to Syngene’ s quality standards at all times.

Candidate Profile
• MPharm
- Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory
- Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methods
- Should be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis
- Should be well versed with internet-based literature search and capable of implementing the Learnings as and when require
- Candidate is expected to have basic understanding in interpretation of Mass/UV Spectra
- Should ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff
- General understanding of Drug metabolism and Pharmacokinetics
- Should be able to deliver scientific presentation in departmental journal club and write official Project reports.
• 2-7 years post qualification
• Should be well versed in verbal and written communication, should be a team player.
• Should be focused towards results and deliverables.
• Should have a high moral framework (ethics code) and high data integrity sense.


Senior Associate Scientist -Invitro ADME Bioanalyst (27253)
Job Description
• Optimization of test compounds and to develop high through put fit for purpose methods to support invitro analysis
• Perform analysis of samples generated while screening of compounds for ADME assays and Processing of different matrices samples of PK studies
• To support MET ID studies and peptide/ large molecule PK analysis
• Excellent written and oral communication skills interacting with internal stake holders
• Operation, maintenance and troubleshooting of HPLC/ LC-MS/MS system
• Preparation of protocols, reports and templates for responsibilities
• Instrument maintenance, calibration and maintaining documentation as per regulatory requirements and company policy
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’ s  data integrity policies
• Compliance to Syngene’ s quality standards at all times.

Candidate Profile
• M.Pharm- In Life Sciences or related stream
• 3-9 Years
• Hands-on experience in handling of LCMS/MS systems is mandatory and experience on TOF/Orbitrap is advantageous
• Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory
• Comprehensive understanding of in vitro ADME assays and technical expertise in trouble shooting the assays. Brief knowledge about Biotransformation of Xenobiotics and basic knowledge on Large molecule analysis using LCMS
• Should be able to deliver scientific presentation in departmental journal club and write official Project reports
• Should be equipped with quality policies related to data management and data integrity
• Decent communication skills
• Fair interpersonal skills.
• Good team player
• Strong documentation Skills.

Additional Information
Experience : 2-5 years
Qualification : M. Pharm
Location : Bangalore
Industry Type : Pharma/ Healthcare/ Clinical research

Mode of interview : Virtual (MS Teams link will be shared with shortlisted candidates one day prior)
Date/Day : 13-Nov-21 (Saturday)
Timings : 9:30 AM to 1 PM

Last date to apply : 11-Nov-21

Apply Associate Scientist Pharmacokinetics>>

Apply Associate Scientist Bioanalytical >>

Apply Senior Associate Scientist ADME Bioanalyst >>

Interested candidates can apply on the above links or share their resumes at Niveditha.G101@syngeneintl.com

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