The Institute of Life Sciences was conceived in the context of globalization, to foster research competence in India and to bridge the divide between academic research and the pharmaceutical & biotechnology industries. The institute was incorporated as a non-profit entity under Section 25 of the Indian companies act, facilitating operational autonomy. Construction of the ILS building comprising 44 labs and an administrative block and spanning -130,000 sq.ft. in area, began in 2004 and was completed in January 2007. The institute was inaugurated as a public-private partnership research institute on 29th January 2007, a culmination of the efforts and initiative of the Andhra Pradesh state government, Dr. Reddy's laboratories and the University of Hyderabad.

Post : Junior Research Fellow

PROJECT TITLE
Identification of the mechanistic basis of early striatal damage in Glutaric Aciduria Type I

FUNDING AGENCY: DBT

Qualification
- Post Graduate Degree in Professional Course (M.Pharm, M.Tech. Biotechnology or similar)
- Post Graduate Degree in Basic Science with NET qualification (M.Sc. Biochemistry/Biotechnology/Genetics/Molecular Biology etc)

NETs accepted: CSIR-NET including LS; GATE, JAM, GPAT, BET, JEST, JGEEBILS, ICMR-JRF and ICAR- AICE Candidates with experience handling Zebrafish, prior hands-on experience with molecular Biology, biochemistry or microbiology techniques are preferred. A possibility of Ph.D enrollment exists, however it is not guaranteed.

EMOLUMENTS AND DURATION : Rs. 25000+HRA per month

Project duration: 3 years. Appointment will be renewed yearly contingent on performance.

PROJECT SUMMARY
Glutaric aciduria type I (GA1) is an autosomal recessive IEM (Inborn errors of metabolism) disorder that arises due to mutations in the enzyme Glutaryl Co-A dehydrogenase (GCDH), and is found to occur with high frequency (~1:5000)certain ethnic groups including the states of AP and Telangana, India. Children with GA1 usually present with macrocephaly at birth, and a trigger such as fever or infection in early childhood results in acute encephalopathic crises and striatal damage, leading to severe dystonia and dyskinesis. There is so far, no way to predict the susceptibility to striatal damage or prevent it, especially in the presymptomatic stages. We hypothesize that imbalance in molecular pathways in GA1 patients in the gestation or newborn stages, could predispose some patients to such striatal damage and our objective is to use a larval zebrafish model of GA1 to identify such molecular changes. A larval zebrafish model will allow access to a developmental window that is inaccessible in mice or others thus making this a necessary and sufficient tool to investigate the mechanistic basis of early striatal damage and contribute to new targets and therapeutic strategies.

Qualified and interested candidates may send their curriculum vitae by e-mail to hr@drils.org on or before deadline mention in the subject line of the mail the following code: - GA1- Biology, Selected candidates will be called for a personal interview to Dr. Reddy’s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad.

Candidates will not be reimbursed for Travel for the Interview, if short listed.