Associate Research Scientist require at InStem


The Institute of Stem Cell Sciences and Regenerative Medicine (inStem), is a premier research centre carrying out frontier research in the field stem cell biology. inStem has initiated a collaborative program of research with the National Centre for Biological Sciences and the National Institute for Mental Health and Neurosciences. The program aims to understand the cellular and molecular basis of mental illness with a long-term goal to develop new therapies. The program involves generation and analysis of cellular models using patient derived human induced pluripotent stem cells (HiPSCs) and its differentiated derivatives.

Post : Associate Research Scientist

• In this position you will specialize in cloning, expression, purification and characterization of challenging recombinant proteins. Position requires coordinated effort with screening and structural biology to elucidate molecular nature of the protein-ligand and protein-drug interaction.
• Hands on experience in cloning, recombinant protein expression and purification
• Coordinate cross-departmental activities for the effective use of purified proteins
• Provide support in biophysical characterization of protein-ligand and protein-small molecule interaction
• Support and enable reproducible large-scale protein purifications in quantity and quality suitable for X-ray crystallography
• Regular data analysis, project updates, literature survey and presentations on the target
• Participate in project team meeting and contribute to the projects intellectually
• Experience in crystallization and solving protein structure by X-ray diffraction and related tools would be an advantage
• Working knowledge of instruments such as protein fermenter, FPLC, circular dichroism, isothermal calorimetry, dynamic light scattering, Surface Plasmon resonance etc
• Maintenance of good laboratory practices in work environment

Essential Duties and Job Functions:
• Working knowledge of affinity purification, gel filtration, FPLC, AKTA, SPR and isothermal calorimetry
• Support protein design, expression and purification to support small-molecule discovery
• Provide support towards biophysical characterization of proteins and protein-ligand complexes to facilitate protein crystallization and protein science studies
• Ensure regular supply of quality proteins for screening as well as structural biology efforts
• Computer skills with extensive experience in data management, data analysis and statistical analysis
• Must be detail oriented, well organized, and have strong communication skills
• Excellent teamwork skills and the ability to work in a fast-paced, multi-disciplinary environment.

Candidate Profile
• Master's degree in discipline of life sciences with 1-3 years of work experience
• Substantial experience in protein chemistry through cloning, recombinant protein expression, purification and crystallization is essential

Additional Information
Experience : 1-3 years
Qualification : M.Sc
Location : Bangalore
Industry Type : Pharma
Functional Area : R&D
End Date : 10th March, 2019

HOW TO APPLY: Interested candidates may send in the following information by email to
• Curriculum Vitae (CV)
• Publication list
• Contact details of three professional referees
• Specify "Structural Biology" and your designation in the subject line of your email

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