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Ph.D, M.Pharm, M.Sc at Syngene Amgen Research Center

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Ph.D, M.Pharm, M.Sc at Syngene Amgen Research Center

Syngene International Ltd is an integrated research, development and manufacturing services company serving the global pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical sectors. Syngene’s 4500+ scientists offer both skills and the capacity to deliver great science, robust data management and IP security and quality manufacturing, at speed, to improve time-to-market and lower the cost of innovation. With a combination of dedicated research facilities for Amgen, Baxter, Bristol-Myers Squibb and Herbalife, as well as 1.9 Million sq. ft. of specialist discovery, development and manufacturing facilities, Syngene works with biotech companies pursuing leading edge science as well as multinationals including GSK and Merck KGaA.

ASSOCIATE SCIENTIST (37323)
Job Purpose
A highly motivated individual with strong interest in in-vitro ADME assays and LC-MS/MS bioanalysis is required for our current replacement. In this position, candidate will support compound screening efforts in standard in-vitro ADME assays.
Key Responsibilities :
• Perform in vitro ADME assays such as solubility, metabolic stability, CYP450 inhibition, plasma protein binding, TDI, IC-50 shift etc.
• Processing of plasma and tissue samples for bioanalysis.
• Operating instruments like LC-MS/MS for compound tuning and analysis, followed by data retrieval, method development of NCEs in plasma and other matrices.
• Analytical problem-solving skills.
• Knowledge on TOF based application.
• Hands on TOF operation is preferable.

Candidate Profile
• MSc (Chemistry/Biological Sciences)/M. Pharm from reputed University.
• 6-8 years in industry.
• Prior experience in handling NCEs, analysis by LC-MS/MS, sample processing.
• Prior experience in standard in vitro ADME assays.
• High inter-personal skills, excellent oral & written communication skills.
• Problem solving, time-management skills, multi-tasking.

Senior Research Associate (37281)
Job Purpose
A highly motivated individual with strong interest in in-vivo/in-vitro Bioanalysis is required for SARC (Syngene Amgen Research center) collaboration. In this position, candidate will provide support to PK/TK bioanalysis and in-vitro ADME assays.
Key Responsibilities :
• Well versed with processing techniques like LLE, SPE and protein precipitation.
• Carryout sample processing from biological matrices including but not limited to plasma, serum, blood etc for bioanalysis.
• Strong knowledge of the concepts and practices associated with HPLC and Mass Spectrometry.
• WinNonlin operational knowledge will be preferable.
• Understand, interpret, and communicate high quality bioanalytical data.
• Ability to handle multiple studies simultaneously.
• Maintenance of assigned analytical lab equipment.
• Attention to detail and effective communication and documentation skills is desired.
• Adherence to Good Research practices of the organization.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene.
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace.
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene’s data integrity policies.
• Compliance to Syngene’s quality standards at all times.


Candidate Profile
• M.Pharm /M. Sc (Analytical chemistry)
• 0-2 years in industry.
• Proficiency with Microsoft Office and Analyst applications.
• Have a general understanding of LC-MS/MS instruments and aware of basic instrument maintenance.
• Proficiency and hands-on experience in LC-MS/MS bioanalysis
• Should conduct bioanalysis of In-vivo (PK/TK)/In-vitro ADME samples using LC-MS/MS.

Senior Research Associate (37281)
Job Purpose
The incumbent will be responsible for developing and executing in vitro ADMET assays in SARC PKDM.
Key Responsibilities :
• Hands-on experience in developing and implementing fit-for-purpose ADMET assays
• Experience in Leading group of ADMET scientists including Discovery Bioanalysis
• In-depth understanding of instrumentation (LCMSMS and UPLC) and have ability to engage in scientific discussion with managers/client while reviewing experimental data.
• Ability to identify and design studies to delineate druggability issues in the drug discovery programs
• Expertise in the Bioanalysis and biomarker analysis including developing of robust bioanalytical methods
• Experience in Biotransformation is a plus
• Experience in conducting metabolism-based assays and appropriate interpretation of results and participate in client meetings
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensuring that there are no safety non-compliances in areas that my team operates in.
• Ensuring adherence to all Syngene policies related to data integrity by all members of the team including self.
• Ensuring all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence.
• Compliance to Syngene’ s quality standards at all times and ensuring the same by the team members.


Candidate Profile
• Ph.D or M.Pharmacy
• Extensive experience and problem-solving ability in Discovery bioanalysis, in vitro ADME assays, biotransformation.
• In-depth understanding of common in vitro ADME assays, their protocols, sample preparation for Bioanalysis and raw data analysis to arrive at ADME values. Knowledge of biochemical and cell-based assays such as Hepatocyte stability, Caco-2 and MDCK is preferred.
• Ph.D with 2-5 years of experiences or M.Pharmacy with 12 years of experience or M.Sc (Biochemistry or Biotechnology) with 12-14 years of experience.
• Good communication skills – verbal and written
• Ability to plan, execute and keep experimental records & prepare protocols as needed
• Mentor junior scientists
• Team player

Virtual Interview Date :  27-Nov-21 (Saturday), 9:30 AM to 1 PM
Mode of interview : Virtual (MS Teams link will be shared with shortlisted candidates one day prior)
Interested candidates can apply on the below links or share their resumes at Susmita.Padhy1@syngeneintl.com

ASSOCIATE SCIENTIST

Senior Research Associate

Research Investigator/Scientist

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