Articles

ABOUT AUTHOR:
Akshay Rajgaria
Kanak Manjari Institute of Pharmaceutical Sciences
Rourkela, Orissa
akshaykrish2007@gmail.com

ABOUT AUTHORS:
*Sambhara Gayatri Deepti¹, Aruna Ragidi¹, A.M.S.Sudhakar Babu¹, P.Venkateswara Rao^2
1Department of Pharmaceutics
²Department of Pharmaceutical Analysis
A.M.Reddy Memorial college of Pharmacy, Narasaraopet, Guntur Dist., Andhra Pradesh, India.
gayatri.dpt11@gmail.com

ABOUT AUTHORS:
Jyoti Malik
Hindu College of Pharmacy,
Sonepat, Haryana
jyotimalik127@gmail.com

ABSTRACT:
There was a need for delivery systems that could maintain a steady release of drug to the specific site of action. Therefore, drug delivery systems were developed to optimize the  therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development. Although the typical implantable pump consists of different mechanisms to regulate drug delivery. The benefits most often provided by the dosage form are expected to be 1) Implantable devices allow site specific drug administration where the drug is needed most. Examples include implants used in the treatment of brain tumors or prostate cancer. This may also allow for significantly lower doses of the drug, which can minimize potential side effects. 2)Implantable devices allow for sustained releaseby the zero-order release rate of a therapeutic agent. The major advantages of these systems contain targeted local delivery of drugs at a constant rate, fewer drugs required to treat the disease state, minimization of probable side effects, and better efficacy of treatment. Due to the development of such sustained release formulations, it is now possible to administer unstable drugs once a week to once a year that in the past required frequent daily dosing.

About Authors:
Enegide Chinedu*, David Arome, Solomon F. Ameh
Department of Science Laboratory Technology (Physiology & Pharmacology Technology),
University of Jos, Jos Nigeria.
*chinex.snow@gmail.com

Abstract
Though remarkable success have been achieved in the discovery and development of various drugs for the treatment and management of several ailments, there is still need for more discoveries. This is due to the reason that some of the drugs currently in use posseses one or more of the following drawbacks (i) high toxicity level (ii) increase lose of effectiveness or low efficacy (iii) costly or (iv) inaccessable. Herbs have now become the main stream for drug discovery and development. Conservative estimate have revealed that there are over 250,000 higher plant species, and only a minute proportion have been screened exhaustively for their possible therapeutic properties. Atleast, over 120 unique pharmacological substances derived from plants are currently being used as drugs in various countries in the world. Apart from the direct use of plant derivatives as therapeutic agents, they can also serve as models for the design, synthesis or semisynthesis of other therpeutic agents. In conclusion, herbs are a reliable source for more discovery and development of new drugs. The scientific community should therefore harness this resource by improving research on it.

About Author:
Mohit Dangwal
DIT Faculty of Pharmacy
Dehradun, Uttarakhand
dangwal_mohit@yahoo.in

ABOUT AUTHORS:
Gazi Juned M.*¹, Javia A.R¹, Sheth A.K¹, Sachinkumar P. Chauhan, Nirmal Shah
¹Department of Pharmacy, Sumandeep Vidyapeeth University,
At & Po Pipariya, Ta.- Waghodia, Dist. Vadodara-391760.
(Gujarat) India
gaziriju89@gmail.com

ABOUT AUTHORS:
^*1Patel Rina B., ²Patel Nilam K.
¹M.pharm(Q.A), Department of Pharmaceutical Sciences
Hemchandracharya North Gujarat University,
²Asst. Professor, Dept. of Pharmaceutical Sciences
Department of Pharmaceutical Sciences, Hemchandracharya North Gujarat University, Patan. Gujarat-384265
*rina_patel2003@yahoo.com

ABSTRACT
A simple, sensitive, rapid, accurate, precise and economical Fourier transform infrared (FTIR) spectrophotometric method has been developed for the determination of Azelastine Hydrochloride (AZH)   in nasal spray preparations. The IR spectrophotometric method was based on the determination of AZH by the measurement of the area of the infrared band corresponding to the carbonyl group centred at the band1636 cm^-1. It was present in the AZH but not in Acetonitrile used as solvent and highest intensity was at the area 1701.08-1584.21 cm^-1. The linearity of AZH was obtained in the concentration range of 5-100 μg/ml. The mean % recovery was 99.67 ± 0.57 %. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method.

About Authors:
Dr. D.k. Sanghi, Rakesh Tiwle*, Puja Karanjekar, Priyanka Hemne, Dileshwari Madavi, Padma Tembhre
Shri Laxmanrao Mankar Institute of Pharmacy,
Amgoan, Gondia, Maharashtra, India- 441902.
rakesh_tiwle@rediffmail.com