Pharmaceutics Articles

AN ARTICLE ON LEAN SIGMA

About Author
Sayani Chakrabarati,
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

Introduction
In pharmaceutical industries, many unprecedented challenges have to be faced regarding cost, time, labour, tough competition by other companies etc. To overcome these problems & curve a significant niche in global market, a new approach has been brought named lean sigma. This concept is used to make work BETTER & FASTER. Many companies have embarked on major improvement programs, including internal re-organization, greater externalization to embrace the biotech culture & capture innovation, & the movement of investments to lower cost countries. The Lean Sigma is a very positive approach in such third-world countries like India. This approach will help to beat the recession after effects very soon with appreciable efficiency.

In Vitro Dissolution Enhancement Of Felodipine

About Authors: V.P. Patel*, M.C. Gohel, R.K. Parikh
*V. P. Patel
M.Pharm, Assistant Professor, R. K. College of Pharmacy, Rajkot, Gujarat, India.
Work was carried out at: Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
M. C. Gohel
Professor and Principal, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India
R. K. Parikh
Professor, Department of pharmaceutical technology,
L. M. College of pharmacy, Ahmedabad, Gujarat, India

Abstract:
With the introduction of combinatorial chemistry and high throughput screening, the properties of new chemical entities shifted towards higher molecular weight and increasing lipophilicity that results in decreasing aqueous solubility. It is not surprising that many drug candidates have poor water solubility since the initial selection of drug candidates are based on activity alone. Other physiochemical and biopharmaceutical properties such as permeability, biopharmaceutics and metabolism are rarely considered during the selection process. The aim of this study was to increase dissolution rate of felodipine poorly soluble drugs from BCS class II by complexation process. Complexation was prepared using β cyclodextrine. Different techniques were employed for preparation of complexation with β cyclodextrin like physical mixture, cogrinding, kneading technology, solvent coevaporation.The physical properties of the prepared solid mass of felodipine was characterized by in vitro dissolution studies, UV- spectroscopy, Fourior transform infrared spectroscopy, differential scanning calorimetry (DSC) and  X-ray powder differaction spectroscopy. Additionaly, phase solubility studies were performed to support the in vitro dissolution study. The results of Fourior transform infrared spectroscopy shows the compatibility of drug with cyclodextrin, while differential scanning calorimetry (DSC) and X-ray powder differaction spectroscopy showed the confirmation of complexation of β cyclodextrin with felodipine.

Role of Essential Medicines in framing National Medicine Policy – An Approach from Concept to Clinic

About Authors: Ashish Chauhan.
Department of Pharmaceutical Sciences,
Lovely Professional University,
Jalandhar, Punjab.

Abstract:
The essence of essential medicines underlies in satisfying the priority health care needs of the population. The selection of essential medicines is one of the core principles of a national medicine policy as it helps to set primacies for all the aspects of the pharmaceutical system and helps in the maintenance of a proficient healthcare system globally. Devising of essential medicines and national medicine policy is fast emerging as global concept of high relevance to the public irrespective of their nationalities. The prevalence of dreaded diseases like HIV, cancer, and a worldwide upsurge in case of malaria, tuberculosis and other infectious diseases with an addendum problem of multidrug resistance has further augmented the relevance of essential medicines and formulation of a rigid comprehensive national drug policy under the endorsement of WHO medicine strategy andimplementing the same under a complete implementation plan or master plan. This review emphasis the development and selection of essential medicines along with Indian scenario. This review also emphasis the mission, objectives, components, devising and implementation of essential medicine policy along with WHO tenets and regulations.

FORMULATION AND EVALUTION OF ENTERIC COATED PELLETS OF PANTOPRAZOLE SODIUM BY EXTRUSION AND SPHERONIZATION METHOD

About Authors:  RAJESH Z. MUJORIYA,
M.PHARM.(PHARMACEUTICS)

Assistant Professor,
sardar patel college of technology, balaghat M.P.

ABSTRACT
Pantoprazole sodium is proton pump inhibitor and used as an antiulcer agent.  The study was undertaken with an aim to formulate pantoprazole sodium enteric coated pellets.
Before going to develop the formulation a detail product literature review was carried out to know about the MUPS and type of dosage form available in market. The present study was focused to formulate delayed release capsule by MUPS Technique.
Average pellets size was determined by sieve analysis and found to be 1680-1200 microns (ASTM sieve no. 12-16). Sieve analysis was the essential step before coating. Because uniform sized pellets undergo effective coating. The result indicates a effective enteric coating and delay the drug release, with 32% acryl ezee solution, is possible. The formulation developed can further be worked on. For identifying a best formulation for delayed release pellets of pantoprazole sodium.

Validation- An important tool of GMP

About Authors:
Karmveer Tomar
B. Pharmacy, MBA(POM)
Asst. Production Manager.

Introduction:
WHO
defines Good Manufacturing Practices (GMP) as “that part of quality assurance which ensures that products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the marketing authorization.” GMP covers all aspects of the manufacturing process:  validated critical manufacturing steps;  approved written procedures and instructions; records to show all steps of defined procedures have been taken. The guiding principle of GMP is that quality is built in to a product, and not just tested in to a product. Therefore, the assurance is that the product not only meets the final specifications, but that it has been made by the same procedures under the same conditions each and every time it is made. There are many ways this is controlled – validation is that part of GMP that ensures that facility systems, equipment, processes, and tests procedures are in control and therefore consistently produce quality product.

RESEALED ERYTHROCYTES AS DRUG CARRIERS

About Authors: Varun Raj Vemula*1, Swathi Thakkalapally2, Chaitanya Kumari Bairi3
1
DepartmentofPharmaceutical Chemistry, Vikas College of Pharmacy, Jangaon, Warangal. Affiliated to Kakatiya University.
2Department of Pharmaceutics, Care College of Pharmacy, Warangal. Affiliated to Kakatiya University.
3Department of Pharmaceutics, TallaPadmavathi College of pharmacy, Warangal. Affiliated to Kakatiya University.

Abstract:
Carrier erythrocytes have been evaluated in thousands of drug administration in humans proving safety and efficacy of the treatments. Carrier erythrocytes, resealed erythrocytes loaded by a drug or other therapeutic agents, have been exploited extensively in recent years for both temporally and spatially controlled delivery of a wide variety of drugs and other bioactive agents owing to their remarkable degree of biocompatibility, biodegradability and a series of other potential advantages. Biopharmaceuticals, therapeutically significant peptides and proteins, nucleic acid-based biologicals, antigens and vaccines, are among the recently focused pharmaceuticals for being delivered using carrier erythrocytes. In this review article, the potential applications of erythrocytes in drug delivery have been reviewed with a particular stress on the studies and laboratory experiences on successful erythrocyte loading and characterization of the different classes of biopharmaceuticals.

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