Pharmaceutics Articles

ABOUT AUTHORS:
*Rakesh Gupta, Hemant Kumar Sharma, Manvendra Jaiswal, Rajeev Sharma, Narendra Nyola, Dr. Rajesh Yadav
Alwar Pharmacy College, M.I.A. Alwar,
Rajasthan, India 301001
rakeshapcpharma@gmail.com

About Authors:
Mr. Salahuddin Mohammed
Associate Professor of Pharmacology, College of Health Sciences,
Department of Pharmacy, Mizan Tepi University,
Mizan Teferi, Ethiopia.
salahuddin_pharma48@yahoo.com

ABOUT AUTHORS:
*¹MR.B.Ashok, ²Dr.K.S.Manjunatha Shetty, ³Dr. Manikanta kumar, Chandra Shekar
¹Master of Pharmacy in Pharmaceutics
²Ph.D Professor and Principal
³Ph.D, Associate Professor
Jawaharlal Nehru Technological University, Hyderabad
Srinivasa Pharmaceutical Institute And Center For Research Burugupally, Vikarabad, R.R Dist, A.P.
ashok.belde@gmail.com

ABSTRACT
The present study was an attempt to formulate and evaluate enteric coated tablets for esomeprazole magnesium dihydrate. Different core tablets were prepared and formulation was selected for further enteric coating, based on the disintegration time. Seal coating was applied to achieve 3% weight gain. Enteric coating was carried out using different polymers like hydroxyl propyl methylcellulose phthalate to achieve 5% weight gain. Disintegration studies showed that the formulations failed in 0.1 N HCl media. Hence the quantity of enteric coating was increased to 8% w/w. In vitro analysis of the developed tablets was carried out. Results from disintegration time and dissolution rate studies indicate that all the esomeprazole enteric tablets prepared possess good integrity, desirable for enteric coated tablets.

About Author:
Dheeraj Fulara
DIT Faculty of Pharmacy, Mussoorie Diversion Road, Dehradun 248009,
Uttarakhand, India.
fularadheerajmpharm@yahoo.com

ABOUT AUTHORS:
*Sambhara Gayatri Deepti¹, Aruna Ragidi¹, A.M.S.Sudhakar Babu¹, P.Venkateswara Rao^2
1Department of Pharmaceutics
²Department of Pharmaceutical Analysis
A.M.Reddy Memorial college of Pharmacy, Narasaraopet, Guntur Dist., Andhra Pradesh, India.
gayatri.dpt11@gmail.com

ABOUT AUTHORS:
Jyoti Malik
Hindu College of Pharmacy,
Sonepat, Haryana
jyotimalik127@gmail.com

ABSTRACT:
There was a need for delivery systems that could maintain a steady release of drug to the specific site of action. Therefore, drug delivery systems were developed to optimize the  therapeutic properties of drug products and render them more safe, effective, and reliable. In comparison with many of the other drug delivery systems, implantable pumps and implants for variable rate delivery are at a crude stage of development. Although the typical implantable pump consists of different mechanisms to regulate drug delivery. The benefits most often provided by the dosage form are expected to be 1) Implantable devices allow site specific drug administration where the drug is needed most. Examples include implants used in the treatment of brain tumors or prostate cancer. This may also allow for significantly lower doses of the drug, which can minimize potential side effects. 2)Implantable devices allow for sustained releaseby the zero-order release rate of a therapeutic agent. The major advantages of these systems contain targeted local delivery of drugs at a constant rate, fewer drugs required to treat the disease state, minimization of probable side effects, and better efficacy of treatment. Due to the development of such sustained release formulations, it is now possible to administer unstable drugs once a week to once a year that in the past required frequent daily dosing.

About Author:
Mohit Dangwal
DIT Faculty of Pharmacy
Dehradun, Uttarakhand
dangwal_mohit@yahoo.in