July 2016

National Institute of Technology Durgapur was set up as Regional Engineering College (REC) in 1960 funded jointly by the Government of India and the Government of West Bengal and was registered under the Registrar of Societies Act. Initially the Chief Minister of West Bengal and subsequently the Minister of Higher Education, the Government of West Bengal was the Chairman of the Board of Governors. It was affiliated to the University of Burdwan. In REC system national integration was considered to be a part and parcel of education, with half the se at allocated to the students from the state while the rest reserved for the students from the other states, which ensured excellent interaction and camaraderie among the students from all corners of the country.

NIT Durgapur invites applications from Indian Nationals for recruitment to Non-teaching posts.

Post : Senior Pharmacist - 1(GN)

CSIR-Central Salt & Marine Chemicals Research Institute is a premier national laboratory under Council of Scientific & Industrial Research (CSIR), New Delhi. The Institute undertakes a wide range of basic and applied R&D projects spanning the areas of chemistry, biology and engineering. The Institute has excellent infrastructure by way of sophisticated analytical instruments, modem laboratories, pilot plants, library, local area network and workshop.

Applications are invited in the prescribed form from talented and result-oriented Indian Nationals for 1 post Scientist/Senior Scientist, as per the following details:

Post : Scientist / Senior Scientist 01 [PwD - HH]

The “Central Government Health Scheme” (CGHS) provides comprehensive health care facilities for the Central Govt. employees and pensioners and their dependents residing in CGHS covered cities.The Central Govt. Health Scheme provides  comprehensive health care to  the CGHS Beneficiaries in India.  The medical facilities are provided through Wellness Centres(previously  referred to as  CGHS Dispensaries) /polyclinics under  Allopathic, Ayurveda, Yoga,  Unani, Sidha and  Homeopathic systems of medicines.

Post : Pharmacist

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

Post : Manager  Remediation  - Internal Audit

Accenture is a global management consulting, technology services and outsourcing company, with approximately 275,000 people serving clients in more than 120 countries. Combining unparalleled experience, comprehensive capabilities across all industries and business functions, and extensive research on the world’s most successful companies, Accenture collaborates with clients to help them become high-performance businesses and governments. The company generated net revenues of US$28.6 billion for the fiscal year ended Aug. 31, 2013.

Post: Clinical data Management

USV is aleading healthcare company with the following areas of focus: Generics, Active Pharmaceutical Ingredients (APIs) and Biosimilars. 68% of our business is contributed by India Operations and the rest by export of APIs and Generics. USV is a 48 year old healthcare company which began as a joint venture with USV&P Inc, a subsidiary of Revlon. Product range consists of Generics, Active Pharmaceutical Ingredients and Biotherapeutics that are manufactured in our modern cGMP compliant plants located in India.

Post : Officers/Sr. Officers

With global revenues of over US$ 4.5 billion, Sun Pharma is the fifth largest specialty generic pharmaceutical company in the world. We provide high-quality, affordable medicines trusted by healthcare professionals and patients in over 150 countries worldwide. Sun Pharma is also India’s largest and most trusted pharmaceutical company. Our global presence is supported by 45 manufacturing facilities across 5 continents.

Post : Sr.Officer/Executive/Sr.Executive

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ABOUT AUTHORS
S. VISWANTH REDDY*, G.AVINASH1, R. SAGAR2
PNR College of Pharmacy,
Shadnagar, Mahaboob Nagar (Dist), Telangana
vishwanth555@gmail.com

ABSTRACT
Pain is an ill defined, disabling accompaniment of many medical conditions. It is often evoked by an external and internal noxious stimulus. It affects millions of people suffering with depression and other psychiatric disorders. Most of the antidepressants are having analgesic capacity to treat the pain by inhibiting nociceptive stimuli by increasing the seratonergic and noradrenergic transmission in CNS.

Objectives
The Present study carried out to investigate the central analgesic activity of potential antidepressants like Fluoxetine, Imipramine, Amitriptyline and to compare the analgesic activity with standard central analgesic Pentazocine.

Methods
Analgesic activity was evaluated by using hot plate and tail immersion models in mice. Fluoxetine (10 mg/kg), Imipramine (20 mg/kg), Amitriptyline(20 mg/kg) were used as test drugs and Pentazocine (10 mg/kg) was used as standard drug. 

Results
In tail immersion model of analgesic activity Fluoxetine possess significant analgesic activity (*p<0.05 at 60 min interval, ***p<0.001 at 90 and 120 min interval) Amitriptyline also showed significant analgesic activity (**p<0.01) at 90 min interval and ***p<0.001 at 120 min interval. Imipramine is the least effective analgesic in this study showed mild analgesic activity (*p<0.05 at 90 min interval and **p <0.01 at 120 min interval).

In hot plate analgesic model Fluoxetine and Amitriptyline possess significant analgesic activity (***p<0.001 at 120 min interval), Imipramine same like above said model less effective, doesn’t shown significant analgesic activity.

Conclusion
All the test drugs significantly reduce the painful stimuli when compared to the control group in both the models. These results suggest that the antidepressants which increase the monoamine transmission in the brain posse’s significant antidepressant activity and might be useful as potent analgesics.