September 2012

This Institute started as “Occupational Health Research Institute” (OHRI) in the year 1966 and was re-christened as “National Institute of Occupational Health” (NIOH) in 1970 presently located in the Eastern part of Ahmedabad. Two Regional Occupational Health Centers (ROHCs) were started at Bangalore in 1977 and at Kolkata in 1980.

About Authors:
A.Prameela Rani¹, V.Hema^2*
1University college of pharmaceutical sciences,
Acharya nagarjuna University, Guntur.
^2*KVSR Siddhartha college of pharmaceutical sciences, Vijayawada.
*hemav_pharma@rediffmail.com

ABSTRACT:
Epilepsy is a disorder of CNS characterized by paroxysmal cerebral dysrhytmia, manifesting as brief episodes of loss or disturbance of consciousness with or without characteristic body movements, sensory or psychiatric phenomenon.
Some drugs such as felbamate, oxcarbazepine, gabapentin, zonisamide, topiramate and pregabalin before consumption their dose and dosage should be checked. All the drugs should be adjusted surely for their dosage especially in renal impairment patients. The present review is on serious effects due to overdosage of various newer anticonvulsants.

About Authors:
Mr. Rajat Kumar Pandeya
M. Pharm., Dept. of Pharmaceutics,
Noida Institute of Engg. & Technology
Greater Noida, India.
rajatkumar.pandeya@gmail.com

ABSTRACT :
Oral disintegrating tablets (ODTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in development of several ODT technologies. This review describes various formulations and technologies developed to achieve fast dissolution/dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilization, molding, sublimation, and compaction, as well as approaches to enhancing the ODT properties, such as spraydrying, moisture treatment, sintering, and use of sugar-based disintegrants. In addition, taste-masking technologies, experimental measurements of disintegration times, and clinical studies are also discussed.

Established in 1995 with a capital of 50 lakhs, Mankind at present is a leading pharmaceutical company of India.

About Authors:
Bhuvnesh^*1, G.Gnanarajan¹, Preeti Kothiyal¹
Department of Pharmacy, Shri Guru Ram Rai Institute of Technology & Science P.O. Box
80, Patel Nagar , Dehradun 248001, Uttarakhand , India¹
*bhuvnesh.grg89@gmail.com

Abstract
Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies.A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time so as to match body’s circadian rhythms with the release of drug which increases the efficacy and safety of drugs by proportioning their peak plasma concentrations during the 24 hours in synchrony with biological rhythm. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems.  Various techniques are available for the pulsatile delivery like pH dependent systems, time dependent systems, etc. A popular class of single-pulse systems is that of rupturable dosage forms. Advantages of the pulsatile drug delivery system are reduced dose frequency; reduce side effects, drug targeting to specific site like colon and many more. Now in market varies technologies of pulsatile drug delivery system like Pulsincap, Diffucaps etc. are launched by pharmaceutical companies.

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