May 2012

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About Authors:
Amit Jain*, Sandesh Jain, A.G. Hariharan, C.K. Sudhakar, Sanjay Jain
Department of Pharmaceutics,
Smriti College of pharmaceutical education, Indore-452001,
Madhya Pradesh, India
*amitjainpharma16@gmail.com

ABSTRACT
The present investigation deals with development of mucoadhesive thermosensitive pluronic lecithin organogel of clotrimazole for vaginal candidasis. To develop more effective treatment for vaginal candidasis, clotrimazole (CT) was formulated as pluronic lecithin organogels (PLOs). Several PLOs formulations composed of clotrimazole (1%) using the thermosensitive polymer Pluronic® F127, Soya lecithin with the mucoadhesive polymer Carbopol 934. Spreadibility, rheological behavior, drug content (%), mucoadhesive force, gelling capacity and in-vitro release profiles of the different formulations were determined. In vitro, sustained release of CT from PLOs was observed. In vivo antifungal activity of CT, tested against Candida albicans vaginitis in agar plate, was significantly prolonged after vaginal delivery using PLOs. These results indicate that CT-containing vaginal PLOs safe, convenient, and effective treatment of vaginal candidasis with reduced dosing interval.

National JALMA Institute for Leprosy and Other Mycobacterial Diseases (ICMR),Tajganj, Agra – 282 001 invites application for filling up the adhoc posts of Contractual Microbiologist (01), Research Associate (01), Research Assistant (5)and JRF (02), SRF (01) and Laboratory Attendant (01) in various ongoing extramural projects funded by ICMR/CSIR/DBT/ICAR/CTD-Govt of India. These posts are purely temporary and on a project mode.

PAREXEL International is a growing, fast-paced, global Clinical Research Organization (CRO) that has helped bring to market 49 of the top 50 selling pharmaceuticals. In fact, we have worked with all 10 of the world's top 10 pharmaceutical companies.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

Mokshagundam Vishveshwarya was born on August 28, 1860 and Muddenahalli(a village) in Chikballapur Taluk, Kolar district, Mysore (Now Karnataka). Vishveshwarya completed his lower secondary course at Chikballapur. After completing his high-school, he joined the central college having stood first in engineering, it was not difficult for him to enter the Bombay Government Service. He joined the engineer's kader as an Assistant Engineer.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.