October 2011

Spansules was established in the year 2000 and commenced commercial manufacturing of Pre-formulation Pharmaceuticals at Hyderabad. Today Spansules has a manufacturing facility within the premises of Pharmaceuticals hub of Hyderabad . The facility was equipped with sophisticated equipments like, fluidized bed coater, Extruders, Spheronisers etc.

About Author: Patil Amol Vilas,* Madgulkar Ashwini R., Bhingare Chandrashekhar L., Bhalekar Mangesh R., Jamadar Shahaji Ambadas
Department of Pharmaceutics,
AISSMS College of Pharmacy,
Kennedy Road, Near R.T.O.,
Pune - 411 001, INDIA

Abstract
Pellets are of great interest to the pharmaceutical industry for a variety of reasons. Pelletized products not only offer flexibility in dosage form design and development, but are also utilized to improve safety and efficacy of bioactive agents. However, the single most important factor responsible for the proliferation of pelletized products is the popularity of controlled release technology in the delivery of drugs. This research article mainly focused on the Surface Morphology and Drug Release Studies on Repaglinide Controlled Release Pellets Prepared by Solution layering method with Blend of PEG - HPMC - EC Polymersof controlled release pellets of Repaglinide. Surface morphology study to revel morphological changes when pellets were exposed to dissolution study and correlate their relation from P1 to P9 batches. Amongst all batches, P1 batch selected for morphological evaluation by using Scanning Electron Microscopy (SEM). XRD study done for powder characterization of drug before and after manufacturing process. Cellulose derivative blend of Hydroxypropyl methylcellulose (HPMC-K100), Ethyl cellulose (EC) and PEG4000, due to their hydrophilic and hydrophobic properties and ease of application provide desired drug release profile Upto 12 Hrs, when used in optimum concentration P1 batch (1:1%).

About Author: 1) Pankaj H. Chaudhary, M.Pharm
Dept. of Pharmacognosy, Government College of Pharmacy,
Kathora Naka, Amravati – 444604, Maharashtra, INDIA.
2) Somshekhar S. Khadabadi*. M.Pharm., PhD.
Dept. of Pharmacognosy, Government College of Pharmacy,
Kathora Naka, Amravati – 444604, Maharashtra, INDIA.

Abstract
In the present study, the aphrodisiac activity of Bombax ceiba Linn. (Bombacaceae) root extract was investigated. The extract (400 mg/kg body wt./day) was administered orally by gavage for 28 days. Mount latency (ML), intromission latency (IL), ejaculation latency (EL), mounting frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and post-ejaculatory interval (PEI) were the parameters observed before and during the sexual behavior study at day 0, 7, 14, 21, and 28. The extract reduced significantly ML, IL, EL and PEI (p < 0.05). The extract also increased significantly MF, IF and EF (p < 0.05). These effects were observed in sexually active and inactive male mice.

About Author: Dhaval G. Shah^*, Dr Manish J. Patel, Dr Laxman J. Patel
Department Of Pharmaceutical Chemistry,
Shree S. K. Patel College Of Pharmaceutical Education & Research,
Ganpat University, Kherva. Dist: Mahesana, Gujarat

Abatract
Human Immunodeficiency Virus is the causative agent of Acquired Immuno Deficiency Syndrome (AIDS), a disease which has claimed twenty millions lives worldwide in the last two decades. Recently Imidazole derivatives, such as N-aminoimidazoles (NAIMS) have been discovered as novel anti- HIV agents. Herein, the results of 2D-QSAR analysis on these inhibitors have been reported. Quantitative Structure Activity Relationship studies have been conducted on a series (25 compounds) of NAIMS with selective HIV inhibition activity using ChemOffice v.8.0 software. The best prediction have been obtained for anti-HIV activity (R²=0.82, Q²=0.73). The equation emphasized the importance of MORAN AUTOCORELATION (BY ATOMIC MASS), GAERY AUTOCORELATION (BY ATOMIC , SHAPE PROFILE(RANDIC MOLECULAR PROFILE), MAXIMAL  ELECTROTOPOLOGICAL EGATIVE VARIATION and Km parameters on biological activity. The equation is validated by test set (8 compounds). The information obtained from this 2D- QSAR may be utilized in the design of more potent NAIMS analogs and anti-HIV agents.

About Author: Devendra Kumar^1*, Durga Prasad Dash¹, Shushank Dixit², Pragya Seth³
Department of Pharmaceutical technology,
¹Sri Satya Sai collage of Pharmacy (Sehore),
²NH-58, Bagpath road bypass, MIET, Meerut,
³Laxmi Narayan College of Pharmacy, Bhopal

Abstract
This study has been undertaken to investigate the effect of methanolic extract of almond nuts of Prunus amygdalus (batsch.) on pylorus ligation gastric ulcers in Wistar rats. Treatment with Prunus amygdalus extract of (200 mg/Kg bodyweight, 400 mg /Kg body weight) and ranitidine (50 mg/ Kg body weight) for 1 hr to the Ethanol and  rats Pylorus ligation were given and absorb the acid parameters. The present study provides a strong evidence of antiulcer activity of Prunus amygdalus extract against gastric lesions. The antiulcer activity is recognized by a reduction in acid-secretary parameters (i.e. total and free acid), gastric volume and ulcer score suggesting that acid inhibition accelerates ulcer healing, thereby strengthening of mucosal barrier. Administration of Prunus amygdalus (200 mg/kg & 400mg/kg p.o.) increased CAT, and GSH levels as compared to the negative control group, which suggests its efficacy in preventing free radical-induced damage. However, significant increase was observed all doses but in 400mg/kg were better results. In this present study was showed that there was present a significant protection for Hexosamine in all treated groups in compare to negative control group. The LPO results in showed that there was significance level difference present in negative control group and all other group that indicated that lipid peroxides enzyme was higher in vehicle treated group. Ulcer score is the counting of spots and severity of damage in gastric part by any moiety such as ethanol. Single drug treatment (200 mg/kg and 400mg/kg of P.A.E.) was effective up to a significant level (P<0.05) in compare to negative control group. Volume of gastric juice indicate the secretions of gastric fluid and it is higher in negative control group and all drug treated group was effective in relation to negative control group (P <0.05).

[adsense:336x280:8701650588]