Orissa

Job for Junior Research Fellow in NITR

NIT Rourkela is one of the premier national level institutions for technical education in the country and is funded by the Government of India. Government of India has elevated the Regional Engineering College, Rourkela to a deemed university under the name of National Institute of Technology, Rourkela.

Applications are invited on prescribed format for the following assignment in a purely time bound research project undertaken in the Department of Life Science of the Institute.


Application are Invited for post of Faculty at School of Pharmacy and Life Sciences, Centurion University

The School of Pharmacy and Life Sciences aims at skill based education with a curriculum designed to prepare di-ploma holders, graduates and postgraduates in Pharmacy for lifelong learning and leadership capabilities. The School looks forward in developing a disease free Nation by initiating an integrative module of academics and research. The Unique model of integrating of Pharmacy with Life Sciences at Centurion University has a visionary of optimizing the pharmacy protocols in the field of Life Sciences creating a broad platform to enhance academic research and scientific development. The module includes topics in Life Sciences like Computational Biology (Bioinformatics), Biotechnology, Microbiology, Botany, Zoology, Environmental Science and other allied sciences.

Application are Invited for post of Faculty Position at School of Pharmacy and Life Sciences, Centurion University, Bhubaneswar


DRUG TARGETS IDENTIFICATION OF MYCOBACTERIUM TUBERCULOSIS BY METABOLIC PATHWAY ANALYSIS:INSILICO PROCESS

Amiya Kumar Ghosh*1,Saptarshi Samajdar2, Shiladitya Palit3,  Rupchand Pandit4
1Department of Pharmaceutical Technology, UTKAL UNIVERSITY, Bhubaneswar- 751004,Odisha, India.
2Centre for Pharmaceutical Sciences and Natural Products, CENTRAL UNIVERSITY OF PUNJAB, Bathinda-151001, Punjab, India
3Department of Pharmaceutics, IITBHU, Varanasi, India
4Department of Pharmaceutical Science & Technology, Birla Institute of Technology, Mesra Ranchi-835215, Jharkhand, India
*amiyaghosh94@gmail.com

ABSTRACT: 
Tuberculosis (TB) has been declared as a global health emergency by the World Health Organization(WHO). This has been mainly due to the emergence of multiple drug resistant strains and the synergy between tubercle bacilli and the human immunodeficiency virus (HIV). Mycobacterium tuberculosis (Mtb) is a pathogenic bacteria species in the genus Mycobacterium and the causative agent of most cases of tuberculosis. Tuberculosis (TB) is the leading cause of death in the world from a bacterial infectious disease. This antibiotic resistance strain lead to development of the new antibiotics or drug molecules which can kill or suppress the growth of Mycobacterium tuberculosis.The need for new antiTB is persistent due to the emergence of drug resistant Mycobacterium tuberculosis. Here we aimto identify new drug targets in Mycobacterium tuberculosis by phylogenomics among the Mycobacterium tuberculosisandcomparative genomics to Homo sapiens. The proposed target discovery pipeline is largely independent of experimental data and based on the assumption that Mycobacterium tuberculosis proteins are likely to be essential if (i) there are no similar proteins in the same proteome and (ii) they are highly conserved across the Mycobacterium tuberculosisof mammals. We have performed an in silicocomparative analysis of metabolic pathways of the host Homo sapiens and the pathogen Mycobacterium tuberculosis (H37Rv). Novel efforts in developing drugs that target the intracellular metabolismof M. tuberculosis often focus on metabolic pathways that are specific to M. tuberculosis. We have identified five unique pathwaysfor Mycobacterium tuberculosis having a number of 60 enzymes, which are nonhomologous to Homo sapiens protein sequences,and among them there were 55 enzymes, which are nonhomologous to Homo sapiens protein sequences.These enzymes were alsofound to be essential for survival of theMycobacteriumtuberculosisaccording to the DEG database. Further, the functional analysis using Uniprot showed involvement of all the unique enzymes in the different cellular components.


Career for Pharmacist at PRM Medical College & Hospital

Applications are invited from eligible candidates for the following posts in prescribed proforma to be filled up on contractual basis at Pandit Raghunath Murmu, Medical College & Hospital, Baripada. The details of different posts, minimum qualification, number of vacancy, remuneration and recruitment procedure are as follows. The reservation policy shall be as per ORV Rules and details of reservation shall be notified later.

Post : Pharmacist - 02


Vacancy for Pharmacist (04 posts) under Directorate of Medical Education Training

Applications are invited from eligible candidates for the following posts in prescribed proforma to be filled up on contractual basis at Saheed Laxman Nayak, Medical College & Hospital, Koraput. The details of different posts, minimum qualification, number of vacancy, remuneration and recruitment procedure are as follows. The reservation policy shall be as per ORV Rules and details of reservation shall be notified later.

Post : Pharmacist - 04


INSILCO MOLECULAR DOCKING STUDY OF DIHYDROISOQUINOLINIUM DERIVATIVES AS DPP IV INHIBITORS IN TYPE II DIABETES MELLITUS

ABOUT AUHTORS
Amiya Kumar Ghosh*1, Shiladitya Palit2, SaptarshiSamajdar3
1Dept. of Pharmacy, Utkal University, Orissa
2Dept. of Pharmacy, IITBHU
3Centre for Pharmaceutical Sc. And Natural Products, Central University of Punjab

amiyaghosh94@gmail.com

ABSTRACT:
With the spread of western lifestyles, the occurrence of diabetes in the world’s population is rising. Diabetes is a complex metabolic endocrine disorder that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. It is classified into two basic forms Type I and Type II diabetes. A major goal for the treatment of type II diabetes is the enhancement of insulin secretion by pancreatic islet b-cells. The current therapeutic agents, although effective in increasing insulin secretion, are associated with undesirable side effects. Dipeptidyl peptidase IV (DPP IV) is responsible for conversion of glucose tolerance (GLP-1), into inactive form. The inhibition of DPP-IV would be beneficial in the treatment of diabetes mellitus. Improved glucose tolerance in diabetic patients was achieved with several small molecules as DPP IV inhibitors, including sitagliptin. The current study was designed to identify a suitable inhibitor agent for DPP IV. Computer-assisted molecular modeling approach has contributed to the successful discovery of several novel antidiabetic DPP IV agents.Someisoquinoline was designed computationally and screened through insilico docking studies against crystal structure of Dipeptidylpeptidase-IV (DPP-IV) ( PDB entry 2P8S )as a projected target for Type 2 Diabetes Mellitus.Insilico docking methodology using Auto Dock vina comprising a search method Genetic Lamarckian algorithm was used. Genetic Lamarckian algorithm performs an Automated Docking and has an advantage of empirical binding free energy force field that allows the prediction of binding free energies for docked ligands. In-silico evaluation shows satisfactory docking results, when compared with standard using docking. It is concluded that investigational ligands has the potential of inhibiting DPP-IV and there by further screening (invitro and invivo) studies can be carried out in order to find out optimized bioflavonoids for treating type2diabetes mellitus.


Opportunity for Pharmacist to work at OHPC | Government Jobs

Consequent to the reform in power sector in Odisha, Odisha Hydro Power Corporation Ltd. (OHPC) was incorporated in 21 st April 1995 under the companies Act 1956. Its objective are:  To acquire, establish, operate, maintain, renovate, modernize in the State of Odisha and else while hydro electric generating stations, thermal and nuclear electric generating stations and any other electric generating stations based on any non-conventional sources of energy.

Post : Pharmacist - 01 post


Opening for Pharmacist in Office of the CDMO, Nabarangpur

Applications are invited from the Candidates having qualification in Diploma in Pharmacy to lill up of 03 posts (SC-1, ST-1, UR-1) the posts are only district cadre contractual posts of Pharmacists (Nabarangpur) Application in prescribed format with all required documents as per Govt. Last date of receiving application 14.03.2017 through registered /speed post only. The application received after due date hall not be entertained. The authority will not be responsible for any postal delay. Publication of draft Merit list in the district website: -18.03.2017 Details may be down loaded from the district website:- nabaranqpur.nic. in

Post: Pharmacists (DDC Nabarangpur)


Recruitment for B.Pharm, D.Pharm at Central Ayurveda Research Institute for Hepatobiliary Disorders | walk in

This Institute intends to engage the following temporary posts purely on contract basis in research projects. Written Test and/ Interview for the posts is scheduled to be held on dates mentioned below in the office of CARIHD, Bharatpur, Near Kalinga Studio, Bhubaneswar-751029, Odisha.

Post : Pharmacist - 02 post


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