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FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF HYDROPHILLIC MATRIX BASED SALBUTAMOL SULPHATE TABLETS
Pankaj Verma*, Tapaswi Rani Dash
M.Pharm, Pharmaceutical Technology
Asst. Prof., Pharmaceutics, School of Pharmacy and Emerging Sciences, Solan
Salbutamol sulphate (SS), a directly acting sympathomimetic drug, is a good candidate for controlled release formulations due to its short half-life of 1.6-3 h but it is quite challenging because of its high water solubility. The purpose of this research work is to design oral controlled-release matrix tablets of Salbutamol Sulphate using hydrophilic polymers, and thus increase patient compliance by reducing its frequency of administration. Salbutamol Sulphate matrix tablets are to be designed by direct compression method using HPMC K4M CR, HPMC K100M CR and Xanthan gum as various release retarding agents. These release rate retardents are used to control the drug release up to 24 h for administration as once daily dose. The compatibility of the drug with the various excipients is to be studied using FT-IR and DSC. The effects of polymer concentration, polymer viscosity and binary mixtures of some polymers on the in-vitro drug release are to be studied. Salbutamol Sulphate matrix tablets are used for the treatment of respiratory disorders like choronic asthma,bronchitis, bronchiolitis, chronic obstructive pulmonary disease (COPD) etc. . It possibly stimulates β-2 reseptors in lungs resulting in relaxation of smooth muscles by its β-2 agonist action.
The School of Pharmacy of the faculty is approved by the AICTE and committed to produce high quality pharmacist's workforce tailor-made to suit the requirements of the industry and community. We aim to develop latest skills among students by imparting current knowledge about research-centered clinical pharmacy and medicine management.
In addition to teaching and research, our faculty members are also involved in professional activities such as consultative services for pharmaceutical industry, clinical pharmacy practice, drug information services, and analysis of traditional remedies.
Ms. Kanika Soni, Ms. Pooja Dhiman*, Mr. Sandeep Singh
Chitkara University, Kalujhanda, Atal Shiksha Kunj,
Barotiwala, Solan [H.P], INDIA
Alzheimer's disease, the commonest cause of dementia in older people which causes immense distress to patients, their caregivers and families. The aetiology of Alzheimer's disease remains unknown, and no treatments reverse or stabilise the disease. Current management focuses on establishing an accurate clinical diagnosis, ensuring appropriate services are provided, supporting caregivers and treating associated non-cognitive problems because Alzheimer’s disease is the main cause of dementia. Dementia affects memory, thinking, language, judgment, behaviour, and a person’s ability to perform normal daily activities. Dementia is a word that describes symptoms of the gradual deterioration of mental functioning that cannot be explained by normal aging. Dementia occurs primarily in people who are over the age of 65, or in those with an injury or disease that affects brain function. While dementia is most commonly seen in the elderly, it is not a normal consequence of the aging process.
Shristi Badhani*, Shivani Sharma, Amrita Kainth, Bharat Parashar
Department of Pharmacy,
Manav Bharti University, Solan, H.P.
Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. They are mainly caused by uses of high doses of chemicals and some drugs. There is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. Therefore there is urgent need, for effective drugs to replace/add those in current use. Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytoconstituents from some medicinal herbs and those medicinal herbs have proven hepatotprotective potential.A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system. In this century clinicalresearch has confirmed the efficacy of some herbs in the treatment of liver related disease. Hence, this review article contributes to the knowledge of reported indigenous plants, which are prevalent for prevention and treatment ofliver disorders.
Chitkara University, Solan [H.P]
The WHO defines drug abuse as “persistent or sporadic excessive drug use inconsistent with or unrelated to acceptable medical practice.” Barbiturates are the drugs which act on the central nervous system and produce depression.
Work as PROFESSIONAL SERVICE REPRESENTATIVES, AREA MANAGER in Karnataka Antibiotics & Pharmaceuticals Ltd.
Karnataka Antibiotics & Pharmaceuticals Ltd., (KAPL) Bangalore is a Government Enterprise. From a modest beginning in 1984, KAPL has grown from strength to strength in the areas of manufacturing and marketing of various life saving and essential drugs. With an ISO accredition from KPMG, Netherlands, KAPL is recognised for its total commitment to quality and services in domestic and international markets. On profit from inception, KAPL facilities are approved by many international clients.
1*Anjali Choba, 2Shikha Attri
1M.Pharma in pharmacology from shoolini university solan, himachal pradesh
2M.Pharm in pharmaceutical chemistry from lachoo memorial college of science and technology, jodhpur
Venomous creatures have a sophisticated mechanism for prey capture which includes a vast array of biologically-active compounds, such as enzymes, proteins, peptides and small molecular weight compounds. The venom peptides are directed against a wide variety of pharmacological targets, making them an invaluable source of ligands for studying the properties of these targets in different experimental paradigms. Much knowledge has been gained in terms of how poisons and venoms and their composite toxins give rise to the syndromes associated with envenoming and poisoning and in some isolated cases there have been a few such agents promoted for therapeutic use. A number of these peptides have been used for the treatment of pain, diabetes, multiple sclerosis and cardiovascular diseases.
Applications are invited for the positions of Research Scholars in the Department of Biotechnology, Bioinformatics and Pharmaceutical Sciences. The research scholars will get an opportunity to work in the following areas under externally funded R&D projects worth Rs. 15.0 crores, including prestigious ones such as a DBT programme support under Centers of Excellence & Innovation in Biotechnology, DBT RGYI, DST-FIST, etc. in addition to DRDO, MoEF, ICMR funded. The Department has a unique distinction of running 12 DST FASTTRACK projects. All research scholars will be registered in PhD under different programmes.
A REVIEW ON ALZHEIMER’S DISEASE WITH THEIR NEUROLOGICAL PATHWAYS PATHOPHYSIOLOGIC MECHANISMS & DRUG TREATMENT ON THEIR TARGET SITE
Ajay Kumar*1, Dr. Bharat Prashar2, Robin Sharma1
1M. Pharm (Pharmacology)
2Head of Pharmacy Department
Manav Bharti University, Solan.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, primarily manifesting as a loss of memory in old aged people. In this disease the destruction of neurons in the cortex and limbic structures of the CNS occurs, particularly in basal forebrain, amygdala, hippocampus, cerebral cortex. These areas are associated with functions of higher learning, memory, reasoning, behaviour, identification, an emotional control in brain. Alzheimer's disease is a devastating disease whose recent increase in incidence rates has broad implications for rising health care costs. Clinically, patients initially present with short-term memory loss, subsequently followed by executive dysfunction, confusion, agitation, and behavioural disturbances. This review comprises aspects of the introduction, history, types, etiology, pathophysiologic mechanisms of neurological pathways of Alzheimer’s disease and the drug treatments and their target site.
1Robin Sharma*, 1Ajay Kumar, 2Dr. Bharat Prashar
2Head of Pharmacy Department
Manav Bharti University, Solan.
Postoperative adhesions are a significant health problem with major implications on quality of life, health care and expenses on treatment. The purpose of this review was to investigate the incidence of post operative adhesions and the treatment measures such as efficacy of preventative techniques and adhesion barriers. The National Library of Medicine, Medline and A-Z databases were used to identify articles related to postoperative adhesions. Ileal pouch–anal anastomosis, open colectomy, and open gynecologic procedures are associated with the highest risk of adhesive small-bowel obstruction (class I evidence). Based on expert opinion (class III evidence) intraoperative preventative principles, such as meticulous haemostasis, avoiding excessive tissue dissection and ischemia, and reducing remaining surgical material such as powdered gloves have been published. Laparoscopic techniques, result in fewer adhesions than laparotomy techniques (class I evidence). Available bioabsorbable barriers, such as hyaluronic acid/carboxymethylcellulose, have been shown to reduce adhesions (class I evidence). Postoperative adhesions are a significant health problem after the surgery. General intraoperative preventative techniques, laparoscopic techniques, and the use of bioabsorbable mechanical barriers in the appropriate cases reduce the incidence and severity of peritoneal adhesions and post operative adhesions.