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FORMULATION AND IN VITRO BIOEQUIVALENCE STUDY OF AMOXYCILLIN & POTASSIUM CLAVULANATE FAST DISPERSIBLE TABLET

ABOUT AUTHORS:
Indra Prakash1*, Jugaldas Chudasama2, Pravin Gupta1, Rahul Dev1, Shashi Shekhar1, Mohit kumar2
1Sir Madanlal Institute of Pharmacy, AlampurHauz, Etawah, Uttar Pradesh, India
2Medicef Pharma, Jhar Majri, Baddi, Himachal Pradesh, India
indra.prakash117@gmail.com

ABSTRACT
The objective of present study was to develop the formulation of Fast Dispersible tablet of Amoxycillin & Potassium clavulanate and perform the in vitro bioequivalence study with trying to enhance the bioavailability of innovator formulation. Reduction in the dose of Amoxycillin and potassium clavulanate tablet was possible by developing Fast dispersible tablet. Fast dispersible tablets are designed to disintegrate quickly in the mouth or disperse in a spoonful of water to become a suspension. They are also divided into two or four parts for easy dose titration, and taste masked for patient compliance. These tablets are given to the children who have difficulty in swallowing so Total 05 formulations were made with different concentration of Crospovidone & MCC and fixed concentration of Croscarmellose sodium and Polacrilin Potassium by dry granulation method. The formulations were evaluated for weight variation, hardness, friability, disintegrating time, dissolution study. All the formulations shows uniform weight, hardness and friability data indicates good mechanical resistance of the tablet. All the tablets were disintegrated between 25-45Sec. The optimized (FR-5) formulation showed good disintegration time and release profile with maximum drug being released than marketed preparation at all-time intervals.


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