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ANTI-HISTAMINIC AND ANTI-SPASMODIC POTENTIAL OF ETHANOLIC EXTRACT OF TEPHROSIA PURPUREA (Linn.) PERS. AERIAL PARTS
Paresh Lallubhai Gajera*, Dalal Mittal V.
Department of Pharmacology, ROFEL,
Shri G. M. Bilakhia College of Pharmacy,
The aim of present study was to evaluate anti-histaminic and anti-spasmodic potential of ethanolic extract of aerial parts of Tephrosia purpurea (Linn.) against experimental animal models. In this study ethanolic extract of aerial parts of Tephrosia purpurea (L.) was prepared and anti-histaminic and anti-spasmodic activity evaluated on isolated goat tracheal chain and rat ileum preparation by dose response curve of histamine and acetylcholine in absence and in presence of ethanolic extract was plotted respectively. The results of present study revealed that EETP inhibits moderately significant (*p <0.05) percentage contraction at 50µg/ml while EETP inhibits significantly (**p<0.01) percentage contraction at 100µg/ml induced by histamine (10µg/ml) and acetylcholine (1µg/ml) in isolated goat tracheal chain and rat ileum preparation respectively. To, concluded, EETP possesses dose dependent antihistaminic and antispasmodic potential. However, future studies are required to focus on the molecular mechanism of responsible phytochemical constituents and establish exact mode of action involved in it.
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