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Career opportunity for CRA 1 / CRA 2 / Senior CRA in Quintiles

Quintiles is the only fully integrated biopharmaceutical services company offering clinical, commercial, consulting and capital solutions worldwide. Our network of 23,000 engaged professionals in 60 countries around the globe works with an unwavering commitment to patients, safety and ethics — ensuring a higher level of healthcare for people. For our biopharmaceutical customers, we help them navigate risk and seize opportunities in an environment where change is constant.
Quintiles is consistently cited as the most favored contract research organization (CRO) in independent surveys of the bio pharma industry and was recently named “2009 CRO of the Year” by the prestigious SCRIP Awards.

Post: CRA 1 / CRA 2 / Sr CRA ( Bangalore / Mumbai / Delhi )-1407480


Application are invited for Pharmacist in Administration of Daman & Diu, Directorate of Medical & Health Services

Applications are invited for filling up the following posts of Pharmacist on regular basis in the Directorate of Medical & Health Services, U. T. Administration of Daman & Diu from the eligible candidates who possess the required Educational Qualification and experience as shown below:

Post: Pharmacist- 01(ST)


Opening for Medical Representative in Trexgen Pharmaceuticals | 10 Posts

We, Trexgen Pharmaceuticals Pvt. Ltd, are an emerging pharmaceutical company based in India’s vibrant pharmaceutical hub, Ahmedabad, in the state of Gujarat. Wemarket world-class quality Generic, Branded Generic and Over-the-Counter (OTC) products. Our company is driven by innovation and our business philosophy is to deliver quality pharmaceutical products to our customers and delivervalues to our stakeholders. With a dynamic team of highly experienced pharmaceutical professionals, we continue to strive toprovide quality pharmaceutical products at affordable prices to all our patients.

Post: Medical Representative


FORMULATION AND EVALUATION OF FAST DISSOLVING FILMS OF RIZATRIPTAN BENZOATE

ABOUT AUTHORS:
*P. Bhatt, M. Patel
Department of Pharma. Technology,
L.J. Institute of Pharmacy, Ahmedabad, Gujarat, India
bhatt_pari@ymail.com

ABSTRACT:
Rizatriptan benzoateis an anti migraine drug. The therapeutic activity of the drug can most likely be attributed to agonist effects at 5-HT1B/1D receptors. It is well absorbed from the gastrointestinal tract, but its oral bioavailability is low (45%) due to first-pass metabolism which makes it an ideal candidate for rapid release drug delivery system. Hence, an attempt was made to prepare and evaluate fast dissolving oral films containing Rizatriptan benzoate as a model drug by solvent casting method using hydrophilic polymers. Various formulations were developed with varying concentration of polymers like HPMC, PVA, PVP K30, Xanthan gum, Guar gum. Citric acid was used as a saliva stimulating agent and Propylene glycol as a plasticizer. The prepared oral films were evaluated for their physicochemical and mechanical parameters such as Physical appearance, surface pH, thickness uniformity, disintegration time, drug content uniformity, folding endurance, tensile strength, percentage elongation, in-vitro drug release. In-vitro release rate of Rizatriptan benzoate was studied in simulated saliva fluid (pH 6.8). From prepared formulations, the optimized plasticizer and polymer combination was selected and 32 factorial design was applied. On basis of factorial design, RSM and contour plots were applied. From factorial design batches the batch with lower disintegration time and good mechanical properties is optimized. This optimized batch was studied for its stability for 1 month. PG was optimized as plasticizer. It was observed that no single polymer was able to produce the film with desired quality hence polymer combination was used. The polymer combination of HPMC E 15 & PVA was optimized. On applying factorial design to this combination, batch with polymer ratio of 1:7 (HPMC: PVA) was optimized. The formulation was found stable after 1 month.


DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF ILAPRAZOLE AND DOMPERIDONE IN PHARMACEUTICAL DOSAGE FORM

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ABOUT AUTHORS:
R.A Tamboli, V.C. Chauhan, M.M. Pathan, S.K. Tirgar, D.A. Shah, R.R. Parmar
APMC College of Pharmaceutical Education and Research,
Motipura, Himmatngar, Gujarat
tambolirushabh@gmail.com

ABSTRACT
A specific,  accurate,  precise  and  reproducible  RP-HPLC  method  has  been  developed  and subsequently validated for the simultaneous determination of Ilaprazole and Domperidone  in pharmaceutical dosage form. The proposed HPLC method utilizes hypersil (Thermo scientific) C18 column (250 mm × 4.6 mm id, 5 μm particle size), and mobile phase consisting of methanol:phosphate buffer (40:60) and pH adjusted to 4.0 with 0.1M glacial acetic acid at a flow rate of 1.0 mL/min. Quantitation was achieved with UV detection at 230 nm based on peak area with linear calibration curves at concentration ranges 5-15 μg/ml for Ilaprazole and 15-45 μg/ml for Domperidone. The retention time of  Ilaprazole and Domperidone were found to be 3.433 min and 5.860 min respectively. The method was validated in terms of accuracy,  precision,  linearity,  limits  of detection,  limits  of  quantitation  and  robustness. This method has been successively applied to marketed formulation and no interference from the formulation excipients was found.


Applications are invited from M.Pharm as Project Fellow in GFSU

Established by the Government of Gujarat, under the flagship of Home Department - Government of Gujarat. The Gujarat Forensic Sciences University is a highly specialized higher education institution that came into existence through an Act: No. 17, passed by the Gujarat State Legislative Assembly, dated the 30th of September 2008. It is the only university across the world, dedicated to Forensic & Investigative Science. The University started functioning from July 2009 onwards and in May 2011, received recognition by the 'University Grants Commission'; as a State University, under Section 22 of the UGC Act 1956.

Post: Project Fellow


Vacancies for Faculty Position as Assistant Professor, Senior Lecturer or Lecturer in National Institute of Pharmaceutical Education and Research, Ahmedabad

The National Institute of Pharmaceutical Education and Research has been established under the aegis of Ministry of Chemicals and Fertilizers, Government of India, Dept. of Pharmaceuticals as a Centre of Excellence in imparting higher education, research and development in pharmaceutical sciences and is the first Institute of its kind in country. The Institute was declared as an Institute of National Importance by Government of India through an Act of Parliament, notified on 26th June 1998. The Institute is a member of the Association of Indian Universities and Association of Commonwealth Universities.

Post: Assistant Professor, Senior Lecturer or Lecturer


PHARMACOGNOSTIC AND PHYSICOCHEMICAL EVALUATION ON FRUITS OF GMELINA ARBOREA

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ABOUT AUTHORS:
*Daya L. Chothani1, N. M. Patel2
1B. K Mody government pharmacy college, Rajkot, Gujarat, India
2Sri B.M. Shah College of Pharmacy, Modasa, Gujarat, India
daya.herb@gmail.com

ABSTRACT
The aim of present study was to carry out pharmacognostic and physicochemical evaluation of fruits of Gmelina arborea. Fresh fruits and dried powder of the fruits were studied by morphology, microscopy, qualitative chemical test and florescence analysis of powdered drug. Other physicochemical parameters were also performed as per WHO guide lines. The detailed microscopy revealed the presence of stone cells, vascular strand and pitted parenchyma. Physicochemical parameters and florescence analysis were also studied. The preliminary phytochemical screening showed the presence of alkaloids, proteins, saponins, sterols, phenolic compounds and carbohydrates. The result of these studies could be useful for identification and standardization of Gmelina arboreafruits.


DEGRADATION STUDY OF CIPROFLOXACIN HYDROCHLORIDE, BROMHEXINE HYDROCHLORIDE AND THEIR COMBINED PHARMACEUTICAL DOSAGE FORM BY SPECTROPHOTOMETRY

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About Authors:
1Avinash M Nagapara*, 2Hasmukh C Nagapara, 1Darshan Madiya, 1Shital Faldu
1Department of Quality Assurance, Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat
2Virani Science College, Rajkot, Gujarat
*avinashnagapara@yahoo.com

Abstract
A stress Degradation study of the combination containing Ciprofloxacin Hydrochloride and Bromhexine Hydrochloride was carried out by various reagent like 1 M NaOH, 1M HCl, 6% H2O2 and Neutral water at higher temperature. This combination is widely used for the treatment of various types of respiratory disorders and COPD. The effects of the various stress conditions were observed in terms of decrease in the peak hight, increase in peaks or slightly change or shifting of the wavelengths. It was found that by applying various stress conditions, 4% to 50% drugs were degraded in case of pure drugs as well as the Commercial formulation. Thus spectrophotometry was successfully utilised for primary stability study of the pure drug as well as the degradation study of Ciprofloxacin Hydrochloride and Bromhexine Hydrochloride.


ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND CILNIDIPINE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM BY RP-HPLC METHOD

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About Authors:
Nehal C. Ghelani*, Ketan Dadhania, Shital Faldu
Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
*nehalghelani10@gmail.com

Abstract
RP-HPLC method was developed for the simultaneous estimation of Olmesartan Medoxmil and Cilnidipine in pharmaceutical dosage form. The separation was achieved Hypersil C18 (250 x 4.6 mm, 5 mm) columnwith Acetonitritle:Phosphate buffer pH 3.6 (70:30 %v/v). Flow rate was maintained at 1.0 ml/ min and UV detection was carried at 270 nm. Retention time for Olmesartan Medoxomil and Cilnidipine was found to be 4.14 min and 7.79 min respectively. The method has been validated for linearity, accuracy and precision. Linearity for Olmesartan Medoxomil and Cilnidipine were in the range of 40 - 200 µg/ml and 10 - 50 µg/ml respectively. The percentage recoveries obtained for Olmesartan Medoxomil and Cilnidipine were found to be in range of 99.96- 100.23 and 98.99-100.03 respectively. The developed method was validated as per ICH guidelines. Developed method was found to be accurate, precise, selective and rapid for simultaneous estimation of Olmesartan Medoxomil and Cilnidipine  in pharmaceutical dosage form.