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NANOCOCHLEATE: NOVEL BYPASS OF CONVENTIONAL DRUG DELIVERY SYSTEM

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ABOUT AUTHORS:
Harsh Vyas1*, Tulsi Upadhyay1, Nirali Thakkar1, Kruti Patel1, Umesh Upadhyay2,
1Students, 2Faculty of pharmacy
Sigma Institute of Pharmacy,
Bakrol, Vadodara, Gujarat, India
*vyas123harsh@gmail.com, tulsiupadhyay90@gmail.com

ABSTRACT:
Nanocochleate is a novel lipid based drug delivery system offering systemic and oral delivery of various charged drug molecules. It is formed by negatively charged lipid bilayer. Nanocochleate can encapsulate drugs which are hydrophobic, positively charged, negatively charged and poor orally bioavailable. It is also very much beneficial for oral absorption for peptide drugs that possess a net positive charge. Nanocochleate is beneficial for molecules having binding sites inside the cell. The property that nanocochleates can facilitate cross membrane diffusion for charged and impermeable molecules finds wide application in drug delivery. Nanocochleate have been proven better than liposomes and more compatible with body environment. They differ from liposomes by its structure and compatibility to the body. Liposomes are lipid bilayer with aqueous inner environment and unlike liposomes nanocochleates are having charged lipid bilayer without aqueous environment and are multilayer lipid matrix i.e. Cochleate.

Various methods of its formulation, structure, merits demerits and wide range of application are described in this article.


Vacancies for Pharmacists in Department of Health & Family Welfare, NRHM - 992 posts

Department of Health & Family Welfare, Government of Gujarat has created wide network of health and medical care facilities in the state to provides primary, secondary and tertiary health care atthe door step of every citizen of Gujarat with prime focus on BPL families, marginalized population and weaker sections in rural and urban slum areas. Department also takes appropriate actions to create adequate educational facilities for medical and paramedical manpower in the state of Gujarat.


DESIGN, DEVELOPMENT AND CHARACTERIZATION OF pH SENSITIVE HYDROGEL FOR INTESTINAL DELIVERY OF PREDNISOLONE

ABOUT AUTHORS:
Patel Juhi D.*, Dr. A.K.Seth, Sachin P Chauhan, Nirmal Shah, Ankur Javia, Chintan Aundhia
Department of Pharmacy, Sumandeep Vidyapeeth University,
At & Po Pipariya, Ta- Waghodia, Dist. Vadodra-391760.(Gujarat) India
pateljuhi63@yahoo.com

ABSTRACT
In the present study pH sensitive hydrogel beads of prednisolone were prepared for intestine delivery system. The cross-linking reinforced chitosan- alginate complex beads were prepared by gelation of anionic sodium alginate, the primary polymer, with opposite charged counter ion to form beads which were further complexed with chitosan as a polyelectrolyte. The pH sensitive hydrogel beads were prepared by the unique ionotropic gelation method by applying 33 full factorial designs. In this present study, influence of various formulation parameters like drug: chitosan ration (1:0.5, 1:1, and 1:2), drug: sodium alginate ratio (1:1, 1:2, 1:3) and concentration of calcium chloride (3%, 4%, 5%) were studied. According to factorial design, total 27 batches were prepared and evaluated. The compatibility of drug with polymer was confirmed by Fourier transform infrared spectroscopy (FT-IR). All the formulation were subjected to percentage yield, drug entrapment efficiency, drug content, particle size, swelling study (In phosphate buffer pH 1.2 as well as in phosphate buffer pH 7.4), and in vitro drug release study. The data was found in the range of 72.00 ± 0.8 % to 92.00 ± 0.7 %,16.49 ± 0.2 % to 70.00 ± 0.2 %, 4.70 ± 0.4 to 13.30 ± 0.5,102.36 ± 2.27 to 138.48 ± 2.25 μm, , in phosphate buffer pH 7.4 between 109.00 ± 0.9 to 168.00 ± 0.4 and 106.60±0.6 to 136.00±0.3 in  phosphate buffer pH 1.2. From the results, B8 formulation was optimized. The prepared beads were enteric coated with 10% Eudragit S 100.  The surface morphology was studied by scanning electron microscopy (SEM) revealed spherical in shape with rough surface. It was reported that there was no swelling in acidic pH but increased in basic pH resulting in increased release of the drug in intestine. Hence it could be concluded that the prepared chitosan-sodium alginate hydrogel beads were satisfactory delivered to the stimulated intestinal fluid, which can be confirmed by further in vivo study.


Career as Production Incharge, Quality Control Incharge in GSFDSL

Gujarat State Forest Development Corporation Ltd. urgently requires at for its Ayurvedic Formlations Manufucturing Unit "DHANVANTRI" at GIDC, Ramagamdi, Por, Dist.Vadodara.


Walk in for experience candidates in QC, Production, Packaging department @ Sun Pharma | Require B.Pharm, M.Pharm, D.Pharm, B.Sc, M.Sc

Sun Pharma ranks amongst India's largest pharma companies We’ve built a reputation for speciality therapy leadership and faster- than-industry growth over the last 30 years. From a modest beginning with five people, our team today exceeds 13,000 and growing, put manufacturing base now spans 25 sites across the world. With a market cap of over $ 16 billion, we’re also India’s most valued pharma brand. To keep pace with our growth plans, we require for our Formulation manufacturing plant at Halo! (Near Baroda):


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A renowned name, NEXTUS SOLUTIONS is a professionally managed organization engaged in offering highly acclaimed consultancy, Training and Placement. With our in- depth expertise and rich experience in the wide range of fields in India and abroad, we adopt a systematic and straightforward approach with every assignment of work we undertake. The effectiveness of our systematic and results-focused approach is reflected in our many long-term client relationships.
Leading for Pharma Company


FORMULATION AND CHARACTERIZATION OF RALOXIFENE BETA-CYCLODEXTRINE INCLUSION COMPLEX FOR SOLUBILITY ENHANCEMENT

ABOUT AUTHORS:
Gazi Juned M.*1, Javia A.R1, Sheth A.K1, Sachinkumar P. Chauhan, Nirmal Shah
1Department of Pharmacy, Sumandeep Vidyapeeth University,
At & Po Pipariya, Ta.- Waghodia, Dist. Vadodara-391760.
(Gujarat) India
gaziriju89@gmail.com

ABSTRACT
Raloxifene is a second genaration selective estrogen receptor modulator used to prevent osteoporosis in postmenopausal women. which is insoluble in water and half life is 27.7 hr. it has estrogen effect on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue. raloxifene needs enhancement of solubility and dissolution rate to improve its oral bipavailability and therapeutic efficasy. among  the various approaches to enhance solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrine is an effective and indutrially accepted technique. In the present  investigation complexation of raloxifene with β-CD was carried out by using various technique like physical blending method, kneading method, solvent evaporation method and co-precipitation method. From the various characterization studies like solubility determination, drug content determination, production yield & in vitro dissolution study, it was observed that there was a significant rise in the aqueous solubility and dissolution rate of the raloxifene from the β-cd incusion complex. from the result of statistical analysis, batch RLX-6 by kneading method was found to be optimised batch, because of the maximum enhancement in solubility and rate of dissolution.  Optimised batch was also studied for compatibility by FTIR studies, and also it was found to be stable for the period of 90 days as per the ICH guidelines.


Job for Ayurvedic Pharmacist in GSFDSL

The National Agriculture Commission (NAC) recommended establishment of Forest Development Corporations in each State to accelerate progress and development of forestry sector. Gujarat State Forest Development Corporation Limited ( GSFDC ) was established in August 1976 and registered under the Companies Act 1956.
In 1979 the Minor Forest Produce (MFP) trade came to be nationalized in Gujarat. The Corporation was entrusted with the task of its execution. This meant translating on the ground the State Policy of protecting economic interest of STs, SCs and other weaker sections, while justifying its corporate status. This corporation gets no grants and budgetary support from the Government.


DESIGNER AND SPECIALITY EGGS: A WAY TO IMPROVE HUMAN DIET

ABOUT AUTHORS:
Hitesh Jain*1,  Parva Jani1, Khushboo Patel1, Priti Yadav1, Kaenat Sindhi1, T.Y Pasha2
1
Sigma Institute of Pharmacy, Baroda, Gujarat, India.
2
Parul Institute of Pharmacy and Research, Baroda, Gujarat, India

*hitesh_hitachi@rediffmail.com

ABSTRACT:
One of the ways to market a new product is to change the old product. The rapid decline in consumption of the eggs over the last 50 year is one of the most challenging problems the industry is facing today. The high cholesterol content in eggs is a major contributing factor. This problem can be minimized by using designer eggs. This review article throws light on what a designer egg is all about and how it can be obtained, the advantages of designer egg over simple egg. Besides designer egg, this article also provides information about the specialty egg and fertile eggs. Designer eggs are those in which the content has been modified from standard egg. The content of the chicken egg can be changed in such a ways as to be more healthful. This designer egg is free from all negative factors and prepared by changing the diet of chicken or manipulating the immune system of laying chickens. Thus, Designer eggs are essentially an ideal food and vitamin supplemented product which offers the benefits like reduced cholesterol content, high unsaturated fatty acids, ideal omega-6 to omega-3 ratio, cardiac benefits, etc.


Vacancies for GM (QC/QA); Manager/Asst. Manager (QC/QA) at Comed - High Exp require

Comed was in 1986, when a team of experienced and energetic Pharma professionals decided to go big and to do something different and better than routine. A seed was sown: a beginning was made. These young, dynamic and experienced future leaders chose Baroda (Now called Vadodara), the Educational and Pharma capital of Gujarat (Western India) as their base, a choice which itself proved to be big contributing factor for growth.

Post: GM (QC/QA); Manager/Asst. Manager (QC/QA)