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PHARMAFIESTA ‘13 on World Pharmacist Day Celebration at Anand Pharmacy College - 25th September, 2013
About the SRKSM Trust
Shri RamKrishna Seva Mandal is a registered society and a public trust established in the year 1954, managing more than 20 academic institutes. The trust believes in providing scientific and value based education by maintaining pace with the ever increasing needs of modern educational environment.
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DESIGN, DEVELOPMENT AND OPTIMIZATION OF OLMESARTAN MEDOXOMIL LIQUISOLID TABLETS USING CENTRAL COMPOSITE DESIGN
Swati k. Nagar*1, Dr. Harsha V. Patel1, Dr.Vishnu A. Patel2, Vinod V. Siju3
1Indukaka Ipcowala College of pharmacy, New V.V.Nagar
2ARCP, Vallabh vidhyanagar
3Anand Pharmacy College, Anand.
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties and solubility of olmesartan medoxomil (OLM) in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: ratio of carrier to coating material (X1) and drug concentration (X2) on angle of repose (Y1), hardness(Y2), saturation solubility study (Y3) and cumulative percentage release at 10 min (CPR 10min)(Y4) of formulation using five level two factor central composite design. The quadratic model generated by the design is of the form: Y = A0 + A1X1 + A2X2 + A3X1X2 + A4X12 + A5X22 + E, where Y is the measured response associated with each factor level combination. Contour and response surface plots were depicted based on the equation given by the model. The optimized formula yields observed values close to the predicted values. The liquisolid tablets were formulated with liquid vehicles, poly ethylene glycol 400 (PEG400) at five drug concentrations, 10% w/w, 15% w/w, 20% w/w, 25% w/w and 30% w/w. Avicel PH102 was used as a carrier material, Aerosil 200 as a coating material and cross carmellose sodium as a disintegrant.In-vitro drug dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation (olmezest), in simulated intestinal fluid (pH 6.8). The drug release rates of LS compacts were higher as compared to directly compressed tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. From this study it concludes that the LS technique is a promising alternative for improvement of dissolution property.
The walk in interviews for the following contractual positions under the College of Veterinary Science and Animal Husbandry. Anand Agricultural I niversity, Anand are arranged on 12 June, 2013 at 10:00 hrs. in the office of the undersigned.
Post: Junior Teaching Associate, Senior Research fellow
1Bhatt Mehul K.*, 2Dr. Captain A.D.
1Department of Pharmacognosy,
Shivam Pharmaceutical Studies & Research Centre,
Valasan-388 326, Anand, Gujarat, India.
2Department of Pharmaceutical chemistry
A. R. College and G. H Patel institute of Pharmacy,
Vallabh Vidyanagar, Anand-380 015, Gujarat, India.
Today estimate that about 80% of people in developing countries still relays on traditional medicine based largely on species of plants and animals for their primary health care. India has one of the richest plant traditions in the world. These are estimated to by around 25,000 effect plant based formulations, used in folk medicine and known to rural communities in India. India’s share in the export of herbals is USD 63 billion which is just 0.2% of the global herbal market. So there is obviously vast scope for Indian manufacturers for entering the growing worldwide opportunity of business in herbal pharmaceutical field. We also have to focus on standardization of herbal products. Pharmaceutical export promotion council i.e PHARMEXCIL is ready to play a key role in this regards. Currently, a majority of the adverse events related to the use of herbal products and herbal medicines that are reported are attributable either to poor product quality or to improper use. Inadequate regulatory measures, weak quality control systems and largely uncontrolled distribution channels may have been contribution to the occurrence of such events. So Pharmacovigilance of herbal medicines is required.
Kanzaria S. H. , Patel D. V., Patel K.V., Gandhi T. R.
Anand Pharmacy College.
Objective: To evaluate anti-inflammatory effect of Capparis aphylla Roth. (CA) using experimental animal models. Material and method: Female Wistar rats (200 to 250gm) were randomly allocated to six groups (n=6). Except group-I (normal control), arthritis was induced in animals of all groups by injection of 0.2 ml Complete Freund’s Adjuvant (6mg/ml) on day one. Additionally Group III (Std) and Group IV–VI (CA-1, CA-2 and CA-3) received Indomethacin (100mg/kg), CA (300 mg/kg ; 240 mg/kg and 190 mg/kg) from day 1 to day 21 orally. Paw volumes of both sides (measured by plethysmography) was recorded on day 0, 7, 14, 21. On 7th, 14th, 21stdays the severity of the secondary lesions was evaluated by measuring body weight, arthritic index, Erythrocyte Sedimentation Rate(ESR), Rheumatoid factor(RF), C- Reactive Protein(CRP), Albumin/Globulin(A/G) ratio, X-ray, histopathology of synovial joints. Result: Capparis Aphylla Roth. significantly prevented the freund’s adjuvant induced changes in body weight, serum A/G ratio , arthritic Index, paw edema, ESR, RF, CRP. the results were comparable with the standard drug indomethacin. Conclusion: Antiinflammatory activity of Capparis aphylla Roth. can beattributed to COX-II inhibition leading to decrease in inflammatory mediator.
Anand Pharmacy College is one of the leading institute of Gujarat, established in 1998 under the aegis of Shri RamKrishna Seva Mandal. The institute has been established with a view to promote excellence in Pharmacy education and to prepare upcoming generation to meet the challenges in the area of Pharmaceutical industries, education, research and development by utilizing leading edge technologies with available resources at the APC.
Application are invited for the following teaching & non teaching posts for its various self financed programmes affiliated to SPU, V.V.Nagar/ GTU, Ahmedabad.
Bhatt Mehul K,
Asst.professor, PhD continue
Department of Pharmacognosy,
Shivam Pharmaceutical Studies & Research Centre,
Valasan-388 326, Anand-380 015, Gujarat, India.
Now-a-days many people of the world are suffering from anxiety, stress and depression. They experience feelings of anxiety before an important event such as exam, business deal or first date. Anxiety disorders however are illness that fills people’s lives with unreal & imaginary fear that are chronic, unremitting and can grow progressively worse. By now, most of us know that anxiety is quite a common complaint and many people have tried some of the various medications used for anxiety. But many don’t know that there are a variety of herbs available used to treat anxiety in natural way. This article includes, “What is Anxiety?” Herbs used to cure Anxiety, depression, and Stress”, and “Natural Self-Healing”.
EFFECT OF LYOPHILIZATION AND CRYOPRESERVATION ON PLANT LEAVES OF TERMINALIA ARJUNA TERMINALIA CATAPPA, TERMINALIA CHEBULA, JATROPHA GOSSYPIFOLIA, JATROPHA CURCAS
1Hardik R. Patel*, 2Upanita C. Patel
1Industrial biotechnologist, 2Microbiologist
Anand, Gujarat, India.
Cryopreservation and lyophilization of plant germplasm has obvious advantages over in vitro storage in term of space saving and improved phytosanitation. We compared cryopreserved and lyophilized leaf as sources for genomic DNA isolation by CTAB protocol and PVP protocol.Our results showed that cryopreservation of leaf tissue yielded high molecular weight genomic DNA. The DNA was suitable for restriction-enzyme digestion and as a template for polymerase chain reaction (PCR) amplification. While these results rule out cryopreserved tissue as a source for DNA isolation, the ability to freeze-dry, powder, and efficiently store voluminous tissue samples for later use in DNA and protein isolation could be of great benefit to laboratories involved in molecular genetics and molecular biology.
*1 Patel Dimpalben Girishkumar, 2 Mr.K.H.Shah, 3 Rohit K Patel, 3Yatish Shukla, 3 Modi B, 3 Nilesh Patel
1 Dharmaj Degree Pharmacy College,
Dist- Anand, Dharmaj -388430, Gujarat
2 Professor, IPCPRC, Dharmaj, Gujarat
3 KAPTAB Pharmaceuticals
The aim of the current investigation is to design oral once daily modified release dosage forms of amoxicillin trihydrate for treatment of pharyngitis/tonsilitis, which release the drug for 24 hours and match with theoretical drug release profile. The tablets and capsules were prepared by the different method using different polymers in different concentrations. The interference of the polymers was ruled out by FT-IR spectroscopy studies. The powder-blends of tablets and drug were evaluated for their physical properties like angle of repose, bulk density, compressibility index, and Hausner ratio and found to be satisfactory. The manufactured tablets were evaluated for in process and finished product quality control tests including appearance, thickness, weight variation, hardness, friability, drug content, and in vitro drug release. All formulations showed appearance, thickness, weight variation, hardness, friability and drug content in specified limit. All formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated that formulation containing 50% ethyl cellulose and 50% methocel was the most successful formulation which was evidenced by similarity (f2) and dissimilarity (f1) factors. The formulated amoxicillin trihydrate tablets followed zero order release kinetics and Higuchi diffusion was the dominant mechanism of drug release, resulting in regulated and complete release within 24 hours. Formulations were subjected to short term stability studies as per ICH guidelines and were found stable. Capsule formulations 16 were evaluated for weight uniformity, drug content and in vitro drug release. The results of dissolution studies indicated that drug release from capsule not extend up to 24hrs. All formulations of capsule failed in in-vitro drug release test. In comparison of tablet and capsule formulations, tablet found to be successful dosage form.