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Clinical courses

  • Newton International Fellowships programme for Researchers at UK

    The Newton International Fellowships Scheme was established in 2008 to select the very best early stage  postdoctoral researchers from all over the world and enable them to work at UK research institutions for a period of two years. The Newton International Fellowships programme is available to eligible applicants from any country outside the UK. 

  • Job as Postdoctoral Research Scientist - Chemical Biology at University of Oxford

    The University of Oxford is a complex and stimulating organisation, which enjoys an international reputation as a world-class centre of excellence in research and teaching. It employs over 10,000 staff and has a student population of over 21,000.

  • PhoreMost Ltd, a biopharmaceutical company has been selected to receive a funding award of £1.4 mn (approximately $2.14 mn USD) from the UK’s innovation agency, Innovate UK, to develop its lead oncology programme targeting mutant KRAS cancers. PhoreMost’s lead therapeutic programme has identified drug candidates to a novel synthetic-lethal target for KRAS.

  • Career opportunity for Senior Clinical Safety Scientist in Novartis

    A global healthcare leader, Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

    Post: Senior Clinical Safety Scientist

  • TO REVIEW THE PATHOGENESIS, TRADITIONAL TREATMENT AND FUTURE TRENDS IN THE DIAGNOSIS AND TREATMENT OF HIV INFECTIONS

    { DOWNLOAD AS PDF }

    About Authors:
    Muhammad Asim Javaid*, Emanual Michael Patelia, Annamaria Gal, Muhammad Saleem Qureshi
    University of Bedfordshire,
    Park Square Campus, Luton, LU1 3JU.
    asimtarar@gmail.com

    Abstract:
    The HIV infection has a major role in the human immunodeficiency syndrome. According to the literature review, the main factor is the reduction of CD4 cells and increment in the growth of B-cells with hypergammaglobulinamia. The HIV has the external glycoprotein-120(gp120) and the trans-membrane protein (gp41) which is attached with the CD4 receptors and one or both chemokine receptors (CCR5, CXCR4) on the surface of the host cell. Before selecting the suitable regimens, resistance testing, efficacy against virus, tolerability, dosing frequency, pill burden, drug interactions and patient preferences must be considered. Initially the combination of 2nRTIs along with third suitable member from any other class may be considered as a suitable treatment. A number of drug classes have been proved effective in the treatment of HIV infections; they are nucleoside nucleotide reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitor, protease inhibitors and entry inhibitors.

  • IDENTIFICATION OF BACTERIAL SPECIES BY COMBINED BIOINFORMATIC AND POLYMERASE CHAIN REACTION

    { DOWNLOAD AS PDF }

    About Authors:
    Emanual Michael Patelia, Bushra Ahmed, Muhammad Javaid, Jayesh Patel, Rakesh Thakur, Mishra Trinath
    Department of Pharmacology, University of Bedfordshire, England,
    United Kingdom, LU1 3JU
    ricky.emanual@gmail.com

    Abstract
    The identification will be carried out by comparing a potential PCR product obtained from an unknown species with other PCR products specific to 5 known species, using the same five set of pairs of primers specific of these five species respectively. This implies that each PCR product obtained for each species has to be specific to each species and can be considered as a marker in this exercise. This specificity will be based on the uniqueness of the chosen template that is to be used for each PCR. In addition, since the PCR products will not be sequenced, they will be differentiated by their size, which will be identified by agarose gel electrophoresis. The PCR product can only be used as a marker that defines a species if the amplified sequence is unique to this species. Therefore, the first step in this exercise will be to identify a suitable sequence to amplify for each species. Following the identification of a suitable template, the size of the PCR will have to be defined; since the comparative analysis will be based not only on the presence of a product but also its size, all PCR products should have different sizes identifiable on agarose gel. Since the size of a PCR product is defined by the location of primers along the sequence, the second step in this exercise will be to design suitable primers. Finally, having defined specific template and primers for each species, PCR will be carried out using the DNA of unknown species as a template with all five sets of primers so that a successful PCR product and its size would identify the unknown species as one of the five species.

  • SEX DETERMINATION USING THE ADVANCED OMIC TECHNIQUES: POLYMERASE CHAIN REACTION AND SDS PAGE GEL ELECTROPHORESIS

    { DOWNLOAD AS PDF }

    About Authors:
    Emanual Michael Patelia*, Emma Spiking
    Department of Pharmacology,
    University of Bedfordshire, England,
    United Kingdom, LU1 3JU
    ricky.emanual@gmail.com

    Abstract:
    The polymerase chain reaction is widely used technique for the amplification of target nucleotides for the gene of interest. Amplification of the SRY gene on the Y chromosome by PCR and the identification by electrophoresis has a major role in sex determination. In the proposed method, the house keeping primer glyceraldehydes phosphate dehydrogenase (GAPDH) as a marker of both total and DNA and mitochondrial RNA and SRY gene should be used for the identification of the unknown samples. In the SDS PAGE gel electrophoresis, two bands are noticeable; first band at 218 bp for GAPDH and second band at 741 bp for SRY gene. The sex chromosomes has a important role in the etiology of normal sexual development. Biopotential gonal needs two chromosomes to the development of ovary. The existence of SRY gene located on the Y chromosome, a testis is developed. The sex ambiguity can be developed by the discodance between chromosomal sex and appearance of the external genitalies.

  • ROLE OF NMDA RECEPTORS IN BRAIN FUNCTIONS

    { DOWNLOAD AS PDF }

    About Authors:
    Emanual michael patelia*, Jigneshkumar Patel, Jayesh Patel, Rakesh Thakur, Zheying Zhu, Annamaria Gal, Emma Spiking, Bhavik Virani. Kaith.
    University of Bedfordshire, England,
    United Kingdom, LU1 3JU
    ricky.emanual@gmail.com

    Abstract:
    There were the lots of expriements done on the NMDA (Ar-Mthyl-D-Aspartate) receptors. The general property of this kind of receptors is their complex and morphological structure. the larger structure like interconnections with the help of gap junctions and the expression of the potassium ion channels allows the K+ ions to transfer through channels and for this reason the homeostasis in the CNS is maintained. The cells like astrocytes are completely responsible for the maintainance of homeostasis in the CNS. Astrocytes contains AMPA and NMDA receptors are also responsible for Ca+2- dependent glutamate release. AMPA or NMDA receptors may produce the damage towards the oligodentrocytes with the help of Ca+2 dependent pathway. Moreover, the receptor studies regarding polydentrocytes having extensive proliferative behavior can able to convert into oligodentrocytes or astrocytes by changing their phenotype  With the help of immunochemistry, by contiet et al; showed the presence of the glial fibrilliary acidic protein and get the point that the rat who was deficient in  astrocytes have had the mRNA transcripts for GluN1 subunit.

  • University of East Anglia invites International Foundation Scholarships 2013-14 Science

    Award title: University of East Anglia Science International Foundation Scholarship.

  • Rhodes Scholarships for supporting outstanding all-round students at the University of Oxford

    The Rhodes Scholarships are postgraduate awards supporting outstanding all-round students at the University of Oxford, and providing transformative opportunities for exceptional individuals.

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