You are hereF&D

F&D


PRONIOSOMAL POWDERED DRUG DELIVERY SYSTEM OF FLURBIPROFEN :FORMULATION AND EVALUATION

About Authors:
*Sunil kumar, Amit kumar shahi, Ravi shanker, R. singh, Dr. R. ParthSarthy, Dr S.K. Prajapati
Kamla Nehru institute of technology and management, Sultanpur.
Bundelkhand university, Department of pharmacy, Jhansi

*sunil.sunilpharma.kumar@gmail.com

ABSTRACT
The purpose of this research is to design proniosomal powder drug delivery system of flurbiprofen in a trial to overcome the adverse effects associated with oral administration of the drug. Conventional chemotherapy for the treatment of intracellular infection is no more effective due to limited permeation of drug into cell. This can be overcome by the use of vesicular drug delivery system. Encapsulation of a drug in vesicular structure can be predicted to prolong the existence of the drug in the systemic circulation and thus enhance penetration into target tissue and reduce toxicity.Proniosomal powder are generally present in transparent, translucent or white texture, which makes them physically stable during storage and transport. Due to the limited solvent system present, the proniosomes formed were the mixture of many phases of liquid crystal, viz. lamellar, hexagonal and cubic phase liquid crystals.The potential of proniosomes as a transdermal drug delivery system for flurbiprofenwas investigated by encapsulating the drug in various formulations of proniosomal powder composed of various ratios of sorbitan fatty acid esters, cholesterol, prepared by slurry method. The formulated systems were characterized in vitro for size, vesicle count, drug entrapment, drug release profiles and vesicular stability at different storage conditions. Stability studies for proniosomal powder were carried out for 4 weeks. The method of proniosome loading resulted in an encapsulation yield of 30.6 – 75.4%. Proniosomes were characterised by transmission electron microscopy. In vitro studies showed prolonged release of entrapped flurbiprofen. At refrigerated conditions, higher drug retention was observed. It is evident from this study that proniosomes are a promising prolonged delivery system for captopril and have reasonably good stability characteristics.


Opportunities for Freshers & Experience in Finecure Pharmaceuticals | Require Chemist Trainee, QA Manager, Production Manager, Sr. Production Chemist, Production Chemist, QA/QC Chemist, F&D Manager

Finecure Pharmaceuticals Limited is leading manufacturers and marketers of Pharmaceutical formulations and Nutraceuticals in several therapeutic segments in dosage forms of Tablets, Capsules, Oral Liquids, Dry Syrup, Powders, Injections, Sachet and Effervescent.
The company is WHO GMP certified and also certified for ISO 9001: 2008, ISO 22000: 2005, ISO 14001: 2004, OHSAS 18001: 2007 quality systems towards High Product Quality Assurance, Environment Management System, Occupational cdxHealth and safety.


Work as Senior Research Scientist - Formulation & Development in Cadila Pharma

Cadila Pharmaceuticals Ltd., one of the largest Indian pharmaceutical companies has presence in 90 countries across the globe catering to over 45 therapeutic areas. The company has one of the best R&D setup in India which forms the backbone of our state-of-the-art manufacturing facilities in India and abroad, approved by various regulatory authorities including USFDA, MHRA (UK).


Job in AKUMS Drugs & Pharma | Require Trainee / Assistant Officer / Officer - QC, Manager QA, Research Scientist-AR&D, Executive in DRA, IPR, packaging development

AKUMS DRUGS & PHARMACEUTICALS LTD is one of the most innovative, productive and research based pioneer organization of India having its registered office at Delhi and various plants in Haridwar, Uttrakhand giving employment to more than 2000 people.


Spansules Pharmatech looking for Manager - QA (Formulations)

Spansules was established in the year 2000 and commenced commercial manufacturing of Pre-formulation Pharmaceuticals at Hyderabad. Today Spansules has a manufacturing facility within the premises of Pharmaceuticals hub of Hyderabad . The facility was equipped with sophisticated equipments like, fluidized bed coater, Extruders, Spheronisers etc.


Cadila Pharmaceuticals looking for Senior Technical Supervisor and Executive - Solid oral & Parentral in formulation plant - 2 posts

Cadila Pharmaceuticals Ltd., one of the largest Indian pharmaceutical companies has presence in 90 countries across the globe catering to over 45 therapeutic areas. The company has one of the best R&D setup in India which forms the backbone of our state-of-the-art manufacturing facilities in India and abroad, approved by various regulatory authorities including USFDA, MHRA (UK).
We have been making rapid strides and as part of our expansion plans, we are looking to acquire talent on an Pan India basis.


Career in Sharon Bio - Medicine Ltd. as Senior Executive - QA (Formulations)

They aim at earning the reputation of being a reliable manufacturer and a force to reckon with in the area of Production of Chemical Intermediates, Bulk Actives and Pharmaceutical Formulations. They aim at being considered a benchmark when it comes to Production efficiency & excellence across the Globe. They see ourselves in the future as contributing to the success of our customers.


Kemwell Pharma looking for Manager - Formulation, R&D, QA

Kemwell Pvt Ltd., established in the year 1972 at Bangalore, Specializes in contract manufacturing for pharmaceutical formulations for various reputed multinations in India. For its expansion plans is looking for yound dynamic personnel.

Post: Manager - Formulation, R&D, QA


Fresher M.Pharm, M.Sc, B.Pharm, B.Sc invited for Marketing Executives, Marketing Managers, Formulation Development in Olefia Biopharma - more than 100 vacancies

Olefia Biopharma Limited, We would like to introduce ourselves as one of the most rapidly emerging FMCG Company in various fields of Pharmaceutical, Cosmetics, Ayurvedics / herbals and biotech.
Olefia Biopharma Limited is utilising MHRA and WHO-GMP Approved manufacturing unit to manufacture various Tablets, Capsule, Syrups, Suspensions and other formulations for its various division viz. Pharmaceutical and Cosmetic i.e. FMCG and exporting to various countries across the Globe.


Indian Immunologicals invites Production Executive- Blending, Formulation

The National Dairy Development Board (NDDB) set up Indian Immunologicals Ltd. (IIL) in 1982 with the objective of making Foot and Mouth Disease (FMD) vaccine available to farmers at an affordable price. The technology for FMD vaccine manufacture was obtained from M/s. Wellcome Foundation Limited, United Kingdom. The plant in Hyderabad today has a capacity to make 80 million trivalent doses of FMD vaccine. Following the successful introduction of Foot &Mouth Disease Vaccine-Raksha, IIL launched the tissue culture vaccine "Raksharab" in 1989. This was the first Indian tissue culture vaccine in the market.