Vijayawada

The School of Pharmaceutical Sciences, Apeejay Stya University offers highly advanced and internationally aligned post-graduate courses in Pharmacy Education. The following courses are on offer:

ABOUT AUTHORS:
G.Venkateswarlu*, M.Muthukumaran, B.krishnamoorthy, Ameren nishat
Montessori Siva Sivani Institute of Science & Technology College of Pharmacy-Mylavaram,
Vijayawada, Andhra pradesh-521230
*venkateswarlu460@gmail.com

ABSTRACT
The goal of this review is to provide a guide for understanding current MS technology. Mass spectrometry (MS) has progressed to become a powerful analytical tool for both quantitative and qualitative applications. Proteomics research, in particular, increasingly depends on MS technologies. Basically, any information gathered from a mass spectrometer comes from the analysis of gas-phase ions. There are three main components of a mass spectrometer: an ionization source, a mass analyzer and a detector the name ‘mass spectrometry’ is a misnomer of sorts. The mass is not what is measured; instead, mass spectrometry determines the mass-to-charge (m/z) ratio or a property related to m/z .A mass spectrum is a plot of ion abundance versus m/z, although in many cases the x-axis is labelled ‘mass’ rather than m/z. The spectrum is presented in terms of Daltons (Da) per unit charge The ability of mass spectrometry analyzing proteins and other biological extracts is due to the advances gained through the development of soft ionization techniques such as electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) that can transform biomolecules into ions. Regardless of the ionization source, the sensitivity of a mass spectrometer is related to the mass analyzer where ion separation occurs.  

ABOUT AUTHORS:
Rajani Pathuri^*, M.Muthukumaran, B.Krishnamoorthy, Amreen Nishat
Montessori Siva Sivani Institute of Science & Technology-College of pharmacy
Mylavaram, Vijayawada, Andhrapradesh-521230
*rajani.prakash4@gmail.com

ABSTRACT
Analytical methods development and validation play important roles in the discovery, development and Manufacture of pharmaceuticals. Method development is the process of proving that an analytical method is acceptable for use to measure the concentration of an API in a specific compounded dosage form which allow simplified procedures to be employed to verify that an analysis procedure, accurately and consistently will deliver a reliable measurement of an active ingredient in a compounded preparation. The analytical method validation is essential for analytical method development and tested extensively for specificity, linearity, accuracy, precision, range, detection limit, quantization limit, and robustness. In summary, analytical method development and validation allows to confirm that an accurate and reliable potency measurement of a pharmaceutical preparation can be performed. 

About Authors:
P. Udaya Lakshmi*, B.Krishnamoorthy, M.Muthukumaran, Amreen Nishat
Montessori Siva Sivani Institute of Science&Technology College of Pharmacy-Mylavaram,
Vijayawada, Andhrapradesh-521230
*udayalakshmi53@gmail.com

ABSTRACT
Liquid chromatography (LC) combined with mass spectrometry (MS) is a powerful tool for qualitative and quantitative analytics of organic molecules from various matrices, and the use of this hyphenated technique is very common in bioanalytical laboratories. LC-MS is an analytical technique that couples high resolution chromatographic separation with sensitive and specific mass spectrometric detection. The technique is still fast developing, particularly in the mass spectrometry area, with vastly improved sensitivity and resolution. It is probably the most powerful technique currently available for pharmaceutical analysis. The role of LC/MS in the pharmaceutical industry during the past decade is examined, and key elements for recent success are illustrated to include significant advances in instrumentation, methodology, and application. The applications are highlighted with reference to the analysis opportunity and analysis strategy implemented. The applications of LC-MS to the studies of in vitro and in vivo drug metabolism, identification and characterization of impurities in pharmaceuticals, analysis of chiral impurities in drug substances and high-throughput LC-MS-MS systems for applications in the "accelerated drug discovery" process are described.

Applications are invited from qualified and suitable candidates to work at ART Centre in various districts of A.P. Interested Candidates can send their biodata duly specify the Name and Post applied, along with copies of their qualification and experience certificates to the address of Concerned Medical Superintendent, of the respective Hospitals (RIMS/District Hospital /Area Hospital/Government General Hospital.)

Post: Staff Nurse, Pharmacist, HIV Research Fellow (Non clinical) in COE

Sanzyme Ltd., is a pharmaceutical manufacturing and marketing company based in Hyderabad for the last 43 years. We are pioneers in manufacturing and Gonodotropins and Probiotics.

Post: Area Business Manager

About Authors:
V.DEEPTHI *, POORNIMA.Y, DR.G.DEVALA RAO, T.SANDEEP REDDY
Department of Pharmaceutical Analysis,
K.V.S.R.Siddharthacollege of pharmaceutical sciences,
Vijayawada-520010, India.
*deepthi759@gmail.com

ABSTRACT
A novel stability-indicating RP-HPLC method has been develop and validated for quantitative analysis of Sitagliptin in the bulk drug and in its pharmaceutical dosage forms using Hypersil–BDS- C18 column (250x4.6mmi.d, 5µ particle size) with 10mM Phosphate buffer (PH-3.5): ACN 60:40%v/v as isocratic mobile phase enabled separation of the drug from its degradation products. UV detection was performed at 260 nm. The method was validated for linearity, accuracy (recovery), precision, sensitivity, ruggedness and robustness. The linearity of the method was excellent over the range 10–60μg/ml (correlation coefficient 0.999). The limits of detection and quantification were 0.21 and 0.640μg/ml, respectively. Recovery of Sitagliptinfrom the pharmaceutical dosage form ranged from 99.99 to 100.05%.

Sitagliptin was subjected to stress conditions (Hydrolysis (acid, base), oxidation,thermal and photo degradation) and the stressed samples were analysed by use of the method. Degradation was observed in acid, base, and 30% H2O2. The drug was stable under the other stress conditions investigated. The degradation products were well resolved from main peak. The forced degradation studies prove the stability indicating power of the method.

About Authors:
A.Prameela Rani¹, V.Hema^2*
1University college of pharmaceutical sciences,
Acharya nagarjuna University, Guntur.
^2*KVSR Siddhartha college of pharmaceutical sciences, Vijayawada.
*hemav_pharma@rediffmail.com

ABSTRACT:
Epilepsy is a disorder of CNS characterized by paroxysmal cerebral dysrhytmia, manifesting as brief episodes of loss or disturbance of consciousness with or without characteristic body movements, sensory or psychiatric phenomenon.
Some drugs such as felbamate, oxcarbazepine, gabapentin, zonisamide, topiramate and pregabalin before consumption their dose and dosage should be checked. All the drugs should be adjusted surely for their dosage especially in renal impairment patients. The present review is on serious effects due to overdosage of various newer anticonvulsants.

Laila group is inviting applications from dedicated scientist to become a part of new innovative and exploratory research program for developing molecules/Nutraceuticals /Botanical drugs for unmet medical needs. The Laila Group has now grown into an enterprise with strong competence in various areas like: Nutraceuticals (Laila Nutraceuticals), Pharmaceuticals (Laila Pharmaceuticals), educational institutes (medical college, engineering college), Sugar & Paper industry and Exports and manufacturing of plant extracts (Laila Impex). Laila group has built a best-in-class research facility that will support the increasing research needs of Nutraceuticals and phytochemicals/botanical drugs.

Cryobanks International India a JV between Cryobanks International USA and RJ Corp  founded in 2006. Cryobanks International is a leader in the collection, processing and banking of umbilical cord blood stem cells. Cryobanks International provides a Private Cord Blood Storage Program for expecting families that wish to privately store their baby's precious stem cells and a Public Cord Blood Donation Program for those who prefer to donate.