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Centre for Chemical and Pharmaceutical Sciences
Central University of Punjab, Bathinda-151001
Activation of immune response is developed in respect to some xenobiotic sensitization, which is supposed to prevent and protect the body from sufferings induced by these xenobiotic. But unfortunately sometime body behaves in a paradoxical manner which misguides the immune system and ultimately turned into a bizarre situation of immune function. One of such response is anaphylactic shock, which is quite fatal if untreated. This review brings insights into the molecular physiology of anaphylactic shock and how some people elicit allergic response to certain substances but not the other. This major catastrophe of the body holds an error of immune system whereas this commentary based review disclosed the synchronization of the unfortunate lessons of the immune system, which makes it a cruel to cause DEATH!
*Rakesh Gupta, Hemant Kumar Sharma, Manvendra Jaiswal, Rajeev Sharma, Narendra Nyola, Dr. Rajesh Yadav
Alwar Pharmacy College, M.I.A. Alwar,
Rajasthan, India 301001
Experimental design is a planned interference in the natural order of events by the researcher. A selected condition or a change (treatment) is introduced. Observations or measurements are planned to illuminate the effect of any change in conditions. Complex designs, usually involving a number of "control groups," offer more information than a simple group design. It involves the Experimental Design and Data Analysis. The various type of experimental design, e.g. Statistical(Randomized Blocks, Latin Square, Factorial Design), Quasi Experimental (Time Series, Multiple Time Series), True Experimental(Pretest-Posttest Control Group, Post-test: Only Control Group, Solomon Four-Group), Pre-experimental (Static Group, One Group Pretest-Posttest, Experimental One-Shot Case Study).Process Models for DOE is common to begin with a process model of the `black box' type (Quadratic model & Linear model).Full factorial designs in two levels, Full factorial designs not recommended for 5 or more factors. Replication provides information on variability, Factor settings in standard order with replication, No randomization and no center points; Randomization provides protection against extraneous factors affecting the results. Contour plot Display 3-d surface on 2-d plot Vertical axis, Horizontal axis, Lines CCD designs start with a factorial or fractional factorial design (with centre points) and add "star" points to estimate curvature; A CCD design with k factors has 2k star points, 3 types of CCD designs, which depend on where the star points are placed Circumscribed (CCC), Inscribed (CCI), Face Cantered (CCF); the value of α is chosen to maintain rotatability.
Institute of Bioinformatics and Applied Biotechnology (IBAB)
Evidence-based medicine (EBM) is the process of systematically reviewing, appraising and using clinical research findings to aid the delivery of optimum clinical care to patients. It is a method of healthcare decision-making that intends to combine the most reliable scientific information with individual expertise and patient preferences in order to offer the optimal diagnostic and therapeutic option for the patient. On the other hand, pharmacogenomics is a whole genome application that examines the single gene interactions with drugs. In recent years, the term personalized medicine has been introduced to represent an approach considering differences among individual patients. In modern medicine, the most important sources of evidence are clinical trials using epidemiological methods, and molecular biological and genetic methods characterizing individual patients.
This paper tries to review the rapid transformation of modern medicine from the ‘evidence-based medicine’ to ‘personalized and genomic medicine’.
Tahseen Sameena*1, S.P.Sethy, Prathima Patil, G.Naresh, Md.Owais Ashraf, Radhika
Department Of Pharmaceutics.
Sushrut Institute of Pharmacy
Taddanpally (V), Pulkal (M), Medak-502293
Scientific research on drug abuse indicates this as being a rising trend among the youth around the globe. An investigation into the experimentation with drugs among the youth showed a rate of increase of 8%. The study also revealed an 85.9% increase in alcohol use and 35.2% increase in tobacco use. Furthermore, the study also suggests an increase in the rate of ecstasy and alcohol usage coupled with drugs and opiates such as heroin. This article will thus endeavour to form a network of Civil Society Organisations (CSOs) whose purpose will be the development and implementation of a joint action plan to prevent substance abuse in around the world, in order to promote active engagement of civil society in this field.
*Govind shukla1, Ms.Shivani prashar2, Ms. M.sarika3, Dr. Sunil Yadav4
1M.Pharm(Ph.D), Product Manager
2Sr. Product Executive, Shrey Nutraceuticals Pvt. Ltd. NewDelhi
3Product Analyst, Lactonova India Hyderabad
4Medical officer-in–charge, BPHC Bamore JHANSI U.P.
Nutrition before and during pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life. Prenatal nutrition addresses nutrient recommendations before and during pregnancy. Birth weight of the newborn at delivery reflects the sufficiency and the quality of maternal nutrient for the fetus during pregnancy. Prenatal nutrition has a strong influence on birth weight and further development of the infant.The present paper reviews the role of prenatal nutrition in pregnancy.
Hitesh Jain*1, Parva Jani1, Khushboo Patel1, Priti Yadav1, Kaenat Sindhi1, T.Y Pasha2
1Sigma Institute of Pharmacy, Baroda, Gujarat, India.
2Parul Institute of Pharmacy and Research, Baroda, Gujarat, India
One of the ways to market a new product is to change the old product. The rapid decline in consumption of the eggs over the last 50 year is one of the most challenging problems the industry is facing today. The high cholesterol content in eggs is a major contributing factor. This problem can be minimized by using designer eggs. This review article throws light on what a designer egg is all about and how it can be obtained, the advantages of designer egg over simple egg. Besides designer egg, this article also provides information about the specialty egg and fertile eggs. Designer eggs are those in which the content has been modified from standard egg. The content of the chicken egg can be changed in such a ways as to be more healthful. This designer egg is free from all negative factors and prepared by changing the diet of chicken or manipulating the immune system of laying chickens. Thus, Designer eggs are essentially an ideal food and vitamin supplemented product which offers the benefits like reduced cholesterol content, high unsaturated fatty acids, ideal omega-6 to omega-3 ratio, cardiac benefits, etc.
Madan Gore*, Chetan Galage
B.Pharmacy, Appasaheb Birnale College of pharmacy,
Sangli District-Sangli, Maharashtra 416416, India.
The management and control of inventory is a problem common to pharmaceutical organization. The problem of inventory does not confine them to profit making business firms. The same types of problems are encountered by social and non-profit organization too.
Inventory problem have been encountered by every society, it was until the 20th century that analytical technique were developed to study the initial impetus for analysis expectedly came from manufacturing sector; inventory is an area of Organization operation that is well developed
Mr. Piyush Tripathi
Kota College of Pharmacy
The term Clinical Research refers to the entire bibliography of a drug from its inception in the lab to its introduction to the consumer market & beyond. Not every compound that is tested in the lab is marketed. Before a drug is marketed, it has to undergo several stages of development.
Scientists from Washington University School of Medicine in St. Louis have discovered bee venom can kill the HIV virus without harming the body.
Sapna Phadtare,* Vaibhav Shinde, Kakasaheb Mahadik
Department of Pharmacognosy, Poona College of Pharmacy,
Bharati Vidyapeeth University, Erandwane,
The world is gifted with wonderful and precious resources such as plants, animals and minerals that form the major part of our medical system. We as humans are so dependent on these natural sources that life without them is beyond imagination. Thus it is of prime importance that we look into the conservation and preservation of natural products. The Indian and international government bodies have developed various laws, rules and conventions to ensure sustainability of such natural products. This article reviews the general laws, rules and regulations developed globally for natural and traditional medicine. Various guidelines like WHO, EMEA, TGA guidelines are looked upon. Some difficulties that are faced regarding regulatory issues of herbal medicines are studied. The Acts like Indian patent Act, Plant Variety Protection Act, Farmer’s rights, terms like Biodiversity and Biopiracy are reviewed in this article.