Factors Affecting Distribution

            Factors affecting distribution of drug
 

• Tissue permeability of DRUG
  1. Physico chemical Property
  2. Physiological barriers

• Organ or tissue perfusion
• Binding of drug to Tissue component
  1. Binding of drug to blood
  2. Binding of drug to extra vascular component

• Miscellaneous

         1. Age
         2. pregnancy
         3. Obesity
         4. Diet
         5. Diseased state
         6. Drug interaction