Factors Affecing Bio Availability

   Factors affecting absorption and Bio-availability

A) Physical properties

• Physical state
  
• Solubility of drug
  
• pH
  

B) Dosage form

• Particle size
  
• Disintegration and dissolution rate
  
• Formulation
  

C) physiological factors

• Gastric motility
• Ionization and gastric emptying
  
• Splanchnic blood flow
  
• Enterohepatic circulation
  
• Metabolism of drug
  
• Pharmacogenetic factors
  
• Disease state
  
• Route of administration
  
• Prensence of other substances