Babar Vishal Bharat.*
Dattakala College of Pharmacy (D. Pharmacy),
In the present study, the hydroalcoholic extracts of Nycatanthes arbortristis Linn. (Parijatha) and Hygrophila spinosa T. Anders (Kokila) and combination of these extracts were compared for their diuretic activity using Lipschitz test. Standard drug used was furosemide (100mg/kg body weight) in 0.9% sodium chloride solution. All the extracts significantly increased urine elimination and Na+, K+, and Cl- excretion as compared to normal saline treated groups. The combination of hydroalcoholic extracts of Nycatanthes arbortristis and Hygrophila spinosa in 1:1 ratio showed better diuretic activity. Comparatively the hydroalcoholic extracts of Nycatanthes arbortristis showed more significant activity than Hygrophila spinosa extracts. The result revealed that Nycatanthes arbortristis is having better diuretic activity than Hygrophila spinosa which supports the traditional use of the plant.