Pune

National AIDS Research Institute invites Scientist-D (Molecular Virology)

National AIDS Research Institute [NARI] was established in October 1992 in Bhosari, Pune on a seven acre plot. The Institute has progressively expanded its activities in various aspects of research on HIV and AIDS through infra-structural development, capacity building & research programmes. The present infrastructure includes the Institute housed in a 28024 sq.


NEPHROTOXICITY INDUCED DUE TO NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) & ARSENIC

About Authors:
Varsha Tanaji Jadhav1*, 2Joyeeta Sanyal
Cilicant Chem.Pvt.Ltd., Microbiologist, Pune
Rasayani Biologic.Ltd., Microbiologist
*varsha.jadhav6@gmail.com

Abstract:-
Nephrotoxcity is the injury or damage to the one or both of the kidneys due to a toxic material. Usually toxic material taken orally results in nephrotoxicity. The kidneys are the most essential organs of the urinary system. They are responsible for the quality, quantity and filtration of the fluids in the body. Every day, the kidneys filter about 180 litres of blood, and about four times as much as the amount that passes through any other organ. Hence the kidneys are more often exposed to toxic substances in the blood and are very vulnerable to damage from those materials. They also help to control blood pressure and other direct cell activities and homeostasis as they produce vitamins and hormones for example hormones erythropoietin, rennin. Other important functions performed by them are regulation of calcium, chloride, sodium ions, and pH control (Taferner B, et al., 2009). The kidneys functional units are the nephrons. Diseases of the kidney are diverse, but they commonly display some characteristic clinical features. These include chronic diseases, acute injuries, urinary tract obstruction and infection, renal damage or failure. Epidemiological results suggest that environmental toxins like heavy metals plays significant role in the development of these diseases. Particularly large amounts of these are disposed of as industrial by-products which are not biodegradable. The incidences of chronic and acute renal failures have risen in past few years. In the America only, kidney diseases are the ninth leading cause of death (Ernesto Sabath et al., 2012). Hence identifying the risk factors associate with these diseases is important to prevent it.This report aims to discuss the physiopathological mechanisms and the consequences of kidney injury due to arsenic and Non Steroidal Anti Inflammatory Drugs (NSAID).


SOP PREPARATION AND FORMAT DESIGNING

ABOUT AUTHOR:
MR. Gunjegaonkar S.M.
Assistance Professor.
Dept. of Pharmacology JSPM’s Charak College of Pharmacy and Research, Wagholi, Pune, Maharashtra.
gunjeshiv@gmail.com

INTRODUCTION:
Standard operating procedures are integral part of all the pharmaceutical companies. To obtain the standard quality product intended for human and animal use, manufactured product must have gone through CGMP rules and regulations. Standard operating procedure is an also part of CGMP and GDP (Good documentation practices). Any process, procedure, activity being carried out at any time, at any step that has to perform according to SOP. Standard operating procedure must be written by a subject expert considering the GMP, working feasibility, accountability and authorized by authorized persons. In the face of a challenging regulatory environment, some leading Pharmaceutical companies have found ways to improve quality and costs significantly. To drive this kind of beneficial change, companies must first create a culture where quality objectives are transparent, well understood, and undoubtedly these goals can be achieved by following certain sets of procedures called as “Standard Operating Procedures” (SOP). Procedures are essential for any plant’s effectiveness and efficiency, and they are regulatory requirement in the Pharmaceutical Industry. A typical Pharmaceutical Industry has an average of 1200- 1300 SOPs. A Parenteral Drug Association (PDA) survey found that a typical pharmaceutical company must manage an average of 1250 CGMP-required SOPs and that the average maintenance burden is 15,000 h per firm.



NCCS invites Multiple Vacancies | Junior Research Fellow, Senior Research Fellow, Research Associate

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.


Pages

 

RECOMMENDED JOBS