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GATE PY – 1993 Question Paper

PART – A

SECTION – I


WALK-IN-INTERVIEW for Research Associate and Junior Research Fellow in Agharkar Research Institute

Agharkar Research Institute (ARI) is an autonomous, grant-in-aid research institute of the Department of Science and Technology (DST), Goverment of India. It was established in 1946 by the Maharashtra Association for the Cultivation of Science as MACS Research Institute and renamed as ARI in 1992 in honour and memory of its founder Director, late Professor S.P. Agharkar.


GATE PY – 1992 Question Paper

PART-A

SECTION – I


Indian Institute of Science Education and Research (IISER) Pune invites for Ph.D. Programme

Indian Institute of Science Education and Research (IISER) Pune is a premier autonomous Institution established by the Ministry of Human Resource Development, Government of India, for promotion of high quality science education and research in the country.

Ph.D. Programme



Multiple vacancies as Scientists @ National Chemical Laboratory - CSIR | Government Job - 14 posts

The Council of Scientific and Industrial Research(CSIR) is an autonomous organization under the Ministry of Science & Technology, Government of India. It is amongst the foremost scientific and industrial research set-ups in the world, having state-of-the-art infrastructure and scientific and technical manpower second to none , CSIR covers practically the entire spectrum of scientific and industrial R&D of national and international importance.


Job as ASM (Medical Representative) in Claris Lifesciences by BR consultancy

Claris Lifesciences is one of the largest sterile injectables pharmaceutical companies in India with a market presence in 91 countries worldwide. We primarily manufacture and market products across multiple markets, and therapeutic segments. A significant majority of these products are generic drugs that are capable of being directly injected into the human body and are predominantly used in the treatment of critical illnesses.

Post: ASM (Medical Representative)


Walk in interview for Junior Research Fellow in Agharkar Research Institute (ARI)

Agharkar Research Institute (ARI) is an autonomous, grant-in-aid research institute of the Department of Science and Technology (DST), Goverment of India. It was established in 1946 by the Maharashtra Association for the Cultivation of Science as MACS Research Institute and renamed as ARI in 1992 in honour and memory of its founder Director, late Professor S.P. Agharkar.


Walk in interview for M.Pharm, M.Sc, M.Tech as Research Associate, Post Doctoral Fellow, SRF in National Centre for Cell Science - Govt of India

The National Centre for Cell Science (NCCS) took birth as National Tissue Culture Facility in March 11, 1986 with a mandate of basic research, teaching & training, and as a national repository for cell lines/hybridomas etc.  The centre is located in the midst of academically enriched environment of University of Pune campus, Pune.
During its transformation, the centre has undergone several changes to facilitate achievement of its goals.  The centre has expanded its scientific charter to strengthen basic research in the areas of cancer biology, cell biology, immunology, genomics and proteomics.


GLYCOGEN SYNTHASE KINASE: A DRUG TARGET IN TREATMENT OF CNS DISORDER

About Authors:
Najneen S. Shaikh1*, Mr. MAYURESH. K. RAUT2
1Sinhgad Institute of Pharmaceutical Sciences (SIPS), Lonavala
2Asst. Professor Of Phamaceutical Chemistry
Sinhgad Technical Education Society,
Kusgaon (Bk), Lonavala- 410401
*naj.pharma.23@gmail.com

ABTRACT
Glycogen synthase   kinase 3 (GSK-3) is a serine/threonine protein kinase, that mediates the addition of phosphate molecules on certain serine and threonine amino acids in particular cellular substrates.
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with these diseases. GSK3 is a widely influential enzyme that is capable of phosphorylating, and thereby regulating, over forty known substrates. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide substrate-specific regulation of the actions of GSK3. Several intracellular signaling cascades converge on GSK3 to modulate its activity, and several neurotransmitter systems also regulate GSK3, including serotonergic, dopaminergic, cholinergic, and glutamatergic systems. Because of changes in these neurotransmitter systems and the actions of therapeutic drugs, GSK3 has been linked to the mood disorders, bipolar disorder and depression, and to schizophrenia.


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