Pune

SPECTROPHOTOMETRIC DETERMINATION OF ROSUVASTATIN CALCIUM IN MARKETED FORMULATION

About Authors
Narsinh N. Potdar*, Pranita P. Kore, Rishikesh V. Antre
Department of Pharmaceutical Chemistry,
JSPM’s Charak College of Pharmacy and Research, Wagholi,
Pune-Nagar Road, Pune-412 207 (India)

*narsinh_potdar@rediffmail.com

Abstract
Three new simple, economic spectrophotometric methods were developed for quantitative estimation of Rosuvastatin Calcium in bulk formulation. First method includes determination of Rosuvastatin Calcium at absorption maxima 252 nm, second method applied was area under curve for analysis of Rosuvastatin Calcium in the wavelength range of 247-257 nm and third method was first order derivative. Beer law obeyed in the concentration range of 5-35 μg/ml for all three methods. The correlation coefficients were found to be 0.974, 0.982 and 0.982by absorption maxima, area under curve and first order derivative spectra. Results of analysis were validated statistically and by performing recovery studies. The mean percent recoveries were found satisfactory for all three methods. The percentage label claim was found in the range of 100.28% to 101.01% .The proposed method was validated statistically and recovery studies.


Applications are invited for the post of Senior Research Fellow in NARI

National AIDS Research Institute [NARI] was established in October 1992 in Bhosari, Pune on a seven acre plot. The Institute has progressively expanded its activities in various aspects of research on HIV and AIDS through infra-structural development, capacity building & research programmes. The present infrastructure includes the Institute housed in a 28024 sq.


Walk in for PG in Pharmacy as Research Associate, Junior Research Fellow in National AIDS Research Institute

National AIDS Research Institute [NARI] was established in October 1992 in Bhosari, Pune on a seven acre plot. The Institute has progressively expanded its activities in various aspects of research on HIV and AIDS through infra-structural development, capacity building & research programmes. The present infrastructure includes the Institute housed in a 28024 sq.


PREPARATION AND CHARACTERIZATION OF FLOATING BIOADHESIVE MICROBEADS OF CLARITHROMYCIN

About Authors:
*Shaikh T. K., Jadhav S.L., Gadhave M.V.
Department of Pharmaceutics,
VJSM’s Vishal Institute of Pharmaceutical Education and Research, Ale,
Pune (411412)
*taiyyab1234@gmail.com

Abstract-
Helicobacter pylori (H. pylori) are one of the most common pathogenic bacterial infections, colonizing an estimated half of all humans. It is associated with the development of serious gastro duodenal disease—including peptic ulcers, gastric lymphoma and acute chronic gastritis. H. pylori reside mainly in the gastric mucosa or at the interface between the mucous layer and the epithelial cells of the antral region of the stomach. The discovery of this microorganism has revolutionized the diagnosis and treatment of peptic ulcer disease. Most antibacterial agents have low minimum inhibitory concentrations (MIC) against H. pylori in culture.

Clarithromycin is readily soluble in the acidic environment of the stomach. In the intestine, where neutral to slightly alkaline pH conditions prevail; however, solubility of the active compound is low, which adversely affects absorption in the lower sections of the intestine due to this oral bioavailability of clarithromycin is low (50 to 55%). Local delivery of clarithromycin floating Microbeads are more beneficial for H. pylori infection in stomach because prolonged residence in stomach which could be possible with cytoprotective-Gastroretentive drug delivery system.Site of absorption of clarithromycin is upper part of GIT, hence delivering the drug through sustained release gastro retentive drug delivery reduces the size of dose.


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