Mumbai

Opportunity to work as Senior Scientific Assistant at University Institute of Pharmaceutical Sciences of Panjab University
M.Sc. (Chemistry & Basic Medical Sciences) OR B. Pharm. OR B.Sc. (Chemistry & Basic Medical Sciences) OR Diploma in Pharmacy

ABOUT AUTHORS:
Pramod Shinde, Vijay s. Savakare
Department of Bioinformatics, Guru Nanak Khalsa College,
Matunga, Mumbai-19, India.
vssavakare@gmail.com

ABSTRACT:
Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle (TCA), making glycolysis its sole energy source. One such enzyme is triose phosphate isomerase. This catalyses the isomerization of D-Glyceraldehyde 3 phosphate to dihydroxy acetone phosphate. An attempt was made to identify the potential phyto inhibitors and inhibit the enzyme as well as to modify their side chain to impure the binding efficiently. Here, two datasets are made such as training set and testing set,in which first, is training set, contain 20 known inhibitors against Triosephosphate Isomerase and second is testing set which contain 7 phyto-inhibitors to be tested. Autodock Vina, a docking tool, is used for molecular docking that utilizes information on conformational variability from ensembles of experimental receptor structure ofTriosephosphate Isomerase. We show that experimentally determined binding orientations and computed energies of known Ligands can be reproduced accurately. It was reported that the presence of phosphate groups in a ligand confers better stable docking.

QUESTIONS AND ANSWERS

GeBBS is a leading provider of healthcare Business Process Outsourcing services to Healthcare Providers (Medical Billing companies, Hospitals, Faculty Practices, ASC’s, LTC’s, etc.) and Pharmacies. We help our clients succeed by leveraging on our domain expertise and technology platforms along with our cost effective approach to global outsourcing.

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Post: Nutritionist, Mumbai

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the new state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India. It is registered under the Societies Registration Act (1860) and the Bombay Public Trust Act (1950). Its Governing Council is headed by the Chairman, Atomic Energy Commission, Government of India.

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

National Institute for Research in Reproductive Health (NIRRH), formerly known as Institute for Research in Reproduction is a premier research institute of the Indian Council of Medical Research (ICMR). It is situated in the vicinity of a number of hospitals and research institutes in central Mumbai. Since its inception in 1970, it has been making vigorous efforts to improve the reproductive health of people through research, education and health care services.

About Authors:
Mary Joseph Parakka^2*, Dr. Smita Nayak ¹,
¹Professor, HOD Department of Pharmaceutics
²Bachelors of Pharmacy, Gahlot Institute of Pharmacy, Navi Mumbai.
*mparakka@gmail.com

Abstract:
This review article is mainly focused on the recent and efficient methods of drug delivery in Transdermal drug delivery system; namely Sonophoresis and Nanotechnology ( as Nanoparticles).
Application of these methods in transdermal drug delivery has improved patient compliance and opened new techniques in T.D.D.S