You are hereMultiple Vacancies in Beatson - UK | Require for Postdoctoral Fellows

Multiple Vacancies in Beatson - UK | Require for Postdoctoral Fellows


Beatson, as one of Cancer Research UK’s core-funded institutes, carry out a programme of world-class science directed at understanding key aspects of cancer cell behaviour, and try to translate these discoveries into new therapies and diagnostic/prognostic tools to help cancer patients. The Institute benefits from close interactions with the University of Glasgow, including strong links with the University’s Institute of Cancer Sciences.

Post: Postdoctoral Fellows

  • Rab-coupling protein (RCP)-mediated receptor trafficking in breast cancer progression {below}

Rab-coupling protein (RCP)-mediated receptor trafficking in breast cancer progression:
Funded by Breast Cancer Campaign

Starting Salary from £28500 - £38000 pa (depending on experience).
3 year fixed term contract

You will study the role of receptor trafficking in mammary carcinogenesis by deploying a newly generated genetically-engineered (GEM) model with mammary-specific knockout of a key Rab GTPase effector, RCP. This will include the isolation and culture of primary tumour cells allowing the implementation of a novel SILAC mass spectrometry approach to define the RCP ‘recyclome' in breast cancer. In addition, the project will contain a substantial amount of live cell imaging to enable the visualisation of RCP's contribution to trafficking of integrins, HER2 and other receptors during metastasis. (J. Cell Biol. 183:143; Cell 139:1327; Nat. Rev. Mol. Cell Biol. 10:843)

A relevant PhD is essential and experience in cell biology/biochemistry, in vivo biology and/or live cell imaging would be an advantage. Applications with CV and names of three referees should be sent to Prof. JC Norman,The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. Email j.norman@beatson.gla.ac.uk. Informal inquiries should be directed to Dr Norman or to Dr Iain Macpherson (iain.macpherson@glasgow.ac.uk).

Closing Date: 21 Spetember 2012

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