Bangalore

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ABOUT AUTHORS
P.Mounika*, Sanjit, Abhishek pandey, Dilraj Yadav
Gautham College of Pharmacy,
Bangalore – 560032

ABSTRACT
Objective: The objective of the present study was to develop Bilayered tablets of Nifedipine and atenolol. Bilayered tablet contains two layers. We can formulate first layer into immediate release and second layer into sustained release for desired action. Nifedipine have half-life 2hrs make the drug suitable for immediate release. Atenolol have half-life 6-7hrs make the drug suitable for sustained release.
Methods: In this formulation using super disintegrants for immediate release, acacia and ethyl cellulose as a polymers for sustained release. Tablets were prepared by wet granulation method. In this study Bilayered tablets of Nifedipine and Atenolol tablets were evaluated for weight variation, hardness, thickness, drug content and In-vitro studies.
Results: Bi-layer tablet is suitable for sequential release of two drugs in combination, separate to incompatible substances and also for immediate release as initial dose and sustained release as maintenance dose. In Immediate release formulation, IR-F-3 formulation gives 98% release within 15min. For sustained effect SR-F-3, SR-F-1 gives 98% release within 8-9hrs. SR-F-2 gives 99% release within 10-11hrs for a longer period of time.
Conclusion: The combination of IF-3 and SR-F-2 suitable for formulation. This formulation is used for Bilayered tablet to combine with sustained released tablet. The evaluation parameters were estimated.

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"We cannot compare straight away with US or Europe and say that these should be community Pharmacy and they are lagging behind. I would say that Yes! we have to improve our services and role as Pharmacist in the community pharmacy that is more important and for that knowledge is important.

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Teva is a global pharmaceutical leader and the world’s largest generic medicines producer, committed to improving health and increasing access to quality health solutions worldwide.  Our employees are at the core of our success, with colleagues in over 80 countries delivering the world’s largest medicine cabinet to 200 million people every day. We offer a uniquely diverse portfolio of products and solutions for patients and we’ve built a promising pipeline centered around our core therapeutic areas.

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ABOUT AUTHORS
P.Mounika^*, Sanjit, Abhishek pandey
Gautham College of Pharmacy
Hebbal, Bengaluru, Karnataka

ABSTRACT:
All active pharmaceutical ingredients are having good therapeutic activity and show poor oral bioavailability , because of poor solubility .The present study is to investigate to improve the solubility of Felodipine using different carriers and different methods of preparation of techniques to identify that which carrier and suitable method of preparation. All formulation are evaluated for hardness, friability, drug content uniformity, and in vitro dissolution studies. Among all the formulations three formulation shows good drug release and the formulation with direct compression method shows good drug release compared to other formulation among all the formulation Polyvinylpyrrolidone (PVP) with direct compression is considered as ideal formulation from the study.

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Novo Nordisk is a global healthcare company with 89 years of innovation and leadership in diabetes care. The company also has leading positions within Haemophilia care, growth hormone therapy and hormone replacement therapy. Headquartered in Denmark, Novo Nordisk employs approximately 33,300 employees in 75 countries, and markets its products in more than 190 countries Novo Nordisk’s B shares are listed on NASDAQ OMX Copenhagen (Novo-B).

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