Ahmedabad

THROMBOPHILIA AND VENOUS THROMBOEMBOLISM IN PREGNANCY: DETECTION AND MANAGEMENT PARADIGM

About Authors:
Ritesh Shah*, Gaurav Chandawat, Rahul Jadav, Bhoomi Arora
Institute Of Clinical Research (India),
Ahmedabad, Gujarat-380013, India
*ritesh_shah99@yahoo.com

ABSTRACT
Venous thromboembolism (VTE) complicates approximately 1 to 2 of 1,000 pregnancies, with pulmonary embolism (PE) being a leading cause of maternal mortality and deep vein thrombosis (DVT) an important cause of maternal morbidity. The main reason for the increased risk of thromboembolism in pregnancy is hypercoagulability, which has likely evolved to protect women from the bleeding challenges of miscarriage and childbirth. Women are at a 4- to 5-fold increased risk of thromboembolism during pregnancy and the postpartum period compared with when they are not pregnant. Eighty percent of the thromboembolic events in pregnancy are venous, with an incidence of 0.61 to 1.72 per 1000 pregnancies.Includes a history of thrombosis, inherited and acquired thrombophilia, maternal age greater than 35, certain medical conditions, and various complications of pregnancy and childbirth.

Despite the increased risk of VTE during pregnancy and the postpartum period, most women do not require anticoagulation. The intensity of the anticoagulation will depend on the indication and the monitoring will depend on the intensity. At the time of delivery, anticoagulation should be manipulated to reduce the risk of bleeding complications while minimizing the risk of thrombosis. There are no large trials of anticoagulants in pregnancy, and recommendations are based on case series, extrapolations from nonpregnant patients and the opinion of experts. Nonetheless, anticoagulants are believed to improve the outcome of pregnancy for women who have, or have had, VTE.


Guar gum: A Potential Natural Hydrophilic Polymer

About Authors:
Pankaj S. Waghere
1*, Malpani Amol2,

1Prin. K. M. Kundnani College of Pharmacy, Mumbai. Maharashtra, India.
2Roland Institute of Pharmaceutical Sciences, Berhampur. Orissa, India.

*waghere.pankaj@gmail.com

ABSTRACT
Hydrocolloids are naturally-occurring plant polysaccharide, in that gaur gum is most useful and validated natural plant polysaccharide. Guar gum and their derivatives are widely used in pharmaceutical dosage forms. Many are used as biodegradable polymeric materials to deliver active pharmaceutical ingredients. Natural polymers can be modified to obtain tailor-made materials for drug delivery systems and to compete with the synthetic biodegradable excipients available in the market. Natural polymers as a drug carrier material are of two types: polysaccharides and proteins. They found both in plants and animals providing several advantages over synthetic polymers.Gaur gums are preferred to those of synthetic origin due to their green, cost-effectiveness, nontoxic, easy availability and for suitable binder in tablet manufacture. The aim of this review is to provide an insight into the many potential applications of gaur gum as pharmaceutical natural excipients.


CORTICOSTEROIDS USE IN PREGNANCY

About Authors:
Patel Brilina M*, Yadav Nisha D, Maheta Payal, Arora Bhoomi
Institute of clinical research India,
Ahmedabad,
Gujarat, India
*patelbrilina@gmail.com

Abstract:
Corticosteroids, often referred to as steroid medications, contain man-made versions of the hormone cortisol. Corticosteroids are mainly used to relieve inflammation. Inflammation occurs when the immune system causes part of the body to become swollen, red and filled with fluid in response to an infection. The immune system is the body’s natural defence against infection and illness. Steroids form an important component in pregnancy to reduce the inflammation and are used since very long time for different conditions in different forms. Though very few molecules are used since very long time. Now increase knowledge in uses of corticosteroids in pregnant women who suffer from asthma, skin diseases, rheumatoid arthritis etc.


Filling up of posts of Technical/ Scientific services of Food Safety and Standards Authority of India - 32 posts

The Food Safety and Standards Authority of India (FSSAI) is an autonomous statutory Authority set up under the Food Safety and Standards Act, 2006 for laying down science based standards for articles of food and to regulate their manufacture, storage, distribution, sale and import to ensure availability of safe and wholesome food for human consumption.


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