MAY 2015 ARTICLE LIST >>
PharmaTutor (May- 2015)
Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 5)
Received On: 25/02/2015; Accepted On: 29/03/2015; Published On: 01/05/2015
AUTHORS: Prakash T. Sangale*1, Dhananjay B. Deshmukh2, Rajesh Bhambere3
1Department of Quality Assurance Techniques,
2Department of Pharmacology,
VJSM’S Vishal Institute of Pharmaceutical Education and Research,
Ale, Junnar, Pune
*prakashsangale091@gmail.com
ABSTRACT: Epilepsy is a chronic disorder characterized by the occurrence of epileptic seizures, with or without characteristic body movements (convulsion)affecting about 50 million people worldwide. Synthetic drugs for the treatment of epilepsy are associated with severe side effects and addiction liabilities upon long term uses. Thus, researchers around the globe are searching for natural resources.Erythrinavariegata and Butea monosperma is a traditional medicinal plant used to treat a seizure.The present studies reveal that the anticonvulsant activity by Erythrina variegate & Butea monosperma of bark & leaf PTZ and MES induced convulsions in wistar rats using Erythrina variegata & Butea monosperma of bark & leaf ethanolic extracts extracted successively. However, the anticonvulsant activity of this plant has not been studied in depth.
In Pentylene tetrazole (PTZ) an maximal electro shock seizure(MES) models test parameters like latncy, onset of tonic convulsions, clonic convulsions and percent protection were observed in the different test groups. Inconclusion, we showed that the ethanolic extract of Erythrina variegata and Butea monosperma has anticonvulsant effect in the both models, suggesting their possible depressant action in the central nervous system. EEBM and EEEV gave significant protection (P<0.001) against PTZ & MES induce convulsion.
How to cite this article: PT Sangale, DB Deshmukh, R Bhambere; Anticonvulsant Effect of Leaf and Bark of Erythrina Variegata Linn and Butea Monosperma (LAM) Taub in different Experimental Convulsion Model in Rats; PharmaTutor; 2015; 3(5); 19-23
[ABSTRACT WITH CITATION] [VIEW AS HTML]
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