Resealed Erythrocytes- As a Carrier

MAY 2014 ARTICLE LIST >>

PharmaTutor (May- 2014)
ISSN: 2347 - 7881

Received On: 03/03/2014; Accepted On: 09/03/2014; Published On: 01/05/2014

AUTHORS: Meenu Sharma*, Saroj jain
Department of Pharmaceutics, Hindu college of pharmacy
Panchayat Bhawan, Gohana Road, Sonipat (Haryana)
meenu99sharma@gmail.com

ABSTRACT:
Amongst various carriers explored for target oriented drug delivery, vesicular, microparticulate and cellular carriers meet several criteria rendering them useful in clinical applications. Lymphocytes, leukocytes, platelets, granulocytes and erythrocytes have been proposed as a cellular carriers. Erythrocytes, also known as red blood cells, and have been the most extensively investigated and found to possess great potential in novel drug delivery. The biocompatibility, non- pathogenicity, non-immunogenicity and biodegradability make them unique and useful carriers. The prime function of these RBCs is to transport gases for respiratory processes. Carrier erythrocytes are prepared by collecting blood sample from the organism of interest and separating erythrocytes from plasma. By using various methods the cells are broken and the drug is entrapped into the erythrocytes, finally they are resealed and the resultant carriers are then called "resealed erythrocytes". Erythrocytes have been proposed as a carriers for a wide range of bioactive components including drugs enzymes, pesticides, DNA molecules and others.

How to cite this article: M Sharma, S Jain; Resealed Erythrocytes - As a Carrier; PharmaTutor; 2014; 2(5); 10-18

[ABSTRACT WITH CITATION] [VIEW AS HTML]

REFERENCES:
1. Green R and. Widder KJ, Methods in Enzymology (Academic Press, San Diego, 1987:pp149.
2. Tortara GJ, Derrickson B, The Cardiovascular System The Blood in Principles of Anatomy and Physiology, 669-672
3. G.J. Torotra and S.R. Grabowski, “The Cardiovascular System: The Blood,” in Principles of Anatomy and Physiology, Publishers, New York, NY, 7th ed., 1993, pp. 566–590.
4. G.M. Ihler,“Erythrocyte Carriers,”Pharmacol. Ther.1989.20, 151–169
5. Green R and Widder K.J., Methods in Enzymology, Academic Press, San Diego, 1987, p. 149.
6. Ropars C., Chassaigne M., and Nicoulau C., Advances in the BioSciences, Pergamon Press, Oxford, 1987, p. 67.
7. Guyton A.C. and Hall J.E., “Transport of Oxygen and Carbon Dioxide in the Blood and Body Fluids,” Textbook of Medical Physiology W.B. Saunders, Philadelphia, PA, 1996, pp. 513–523.
8. Jain S. and Jain N.K., “Engineered Erythrocytes as a Drug Delivery ystem,” Indian J. Pharm. Sci. 1997; 59: 275–281.
9. Lewis D.A. and Alpar H.O. Therapeutic Possibilities of DrugsEncapsulatedin Erythrocytes. Int. J. Pharm. 1984; 22: 137–146.
10. Jaitely V. et al., “Resealed Erythrocytes: Drug Carrier Potentials and Biomedical Applications,” Ind. Drugs1996; 33: 589–594.
11. Summers M.P., “Recent Advances in Drug Delivery,” Pharm. J. 1983; 230: 643–645.
12. M.P. Summer. Recent Advances in Drug Delivery, Pharm. J., 1983; 230, 643–645.
13. Torotra G.J. and Grabowski S.R. The Cardiovascular System: The Blood, in Principles of Anatomy and Physiology Harper Collins College Publishers, New York, NY, 7th ed., 1993; 566–590. System’s Activity in Lowering Blood Levels of Urea in Animal Models, biochemistry soc.trans, 1976; 4:677.
14. M. Hamidi and H. Tajerzadeh, “Carrier Erythrocytes: An Overview,” Drug delivery, 2003, 10, 9–20 .
15. J.R. Deloach, R.L. Harris, and G.M. Ihler, “An Erythrocyte Encapsu- lator Dialyzer Used in Preparing Large Quantities of Erythrocyte Ghosts and Encapsulation of a Pesticide in Erythrocyte Ghosts,”Anal. Biochem. 1980, 102, 220 227
16. E. Pitt et al., “Encapsulation of Drugs in Intact Erythrocytes: An Intravenous Delivery System,” Biochem. Pharmacol. 22, 1983, 3359–3368.
17. J.R. Deloach and G.M. Ihler, “A Dialysis Procedure for Loading of Erythrocytes with Enzymes and Lipids,” Biochim. Biophys. Acta. 1977. 496, 136–145
18. D.A. Lewis and H.O. Alpar, “Therapeutic Possibilities of Drugs Encapsulated in Erythrocytes,” Int. J. Pharm. 22, 1984, 137–146
19. H. Davson and J.F. Danielli Dannen Conn. Hanfer Publishing Co Germany, 1970, p. 80.
20. U. Benatti et al., “Comparative Tissue Distribution and Metabolism of Free Versus Erythrocyte-Encapsulated Adriamycin in the Mouse, Adv. Biosci. (series) 67, 1987, 129– 136.
21. K. Kinosita and T.Y. Tsong , “Hemolysis of Human Erythrocytes by a Transient Electric Field,” Proc. Natl. Acad. Sci. USA 74, 1977, 1923–1927.
22. Jain S, Jain NK, and Dixit VK, “Erythrocytes Based Delivery of Isoniazid: Preparation and In VitroCharacterization,” Indian Drugs 1995; 32: 471–476.
23. M. Hamidi et al., “In VitroCharacterization of Human Intact Erythrocytes Loaded by Enalaprilat,”Drug Delivery 2001; 8:231–237.
24. Updike SJ and Wakamiya RT, “Infusion of Red Blood Cell- Loaded Asparaginase in Monkey,” J. Lab. Clin. Med. 1983; 101: 679–691.
25. D.A. Lewis. Red Blood Cells for Drug Delivery, Pharm. J., 1984; 32: 384–385.
26. H.O. Alpar and W.J. Irwin. Some Unique Applications of Erythrocytes as Carrier Systems, Adv. Biosci. (Series) 1987; 67: 1–9.
27. Alvarez IJ. Cross- Linking Treatment of Loaded Erythrocytes Increases delivery of Encapsulated Substance to Macrophages, Biotechnology. Appl. Biochem. 1998; 27:139-143.
28. M Gallo, P K Gupta, C T Hung, D G Perrier, J. Pharm. Sci. 1978. 78-190.
29. J.R. Deloach and G.M. Ihler, A Dialysis Procedure for Loading of Erythrocytes with Enzymes and Lipids, Biochim. Biophys. Acta. 1977; 496, 136–145.
30. V. Jaitely et al. Resealed Erythrocytes: Drug Carrier Potentials and Biomedical Applications, Indian Drugs, 1996; 33:589– 594.
31. M.P. Summer. Recent Advances in DrugDelivery, Pharm. J., 1983; 230, 643–645.
32. Talwar N, Jain NK. Erythrocytes as carriers of primaquin preparation, characterization and evaluation. J. Control Release 1992; 20: 133–142.
33. Pei I, Encapsulation of Phosphotriesterase within Murine Erythrocytes, Toxicol, Appl. Pharmacol. 1994; 124: 296-301.
34. Zocchi E. et al. In-Vivo Liver and Lung Targeting of Adriamycin Encapsulated in Glutaraldehyde Treated Murine Erythrocytes, Biotechnology.Appl.Biochem.1988; 10:555–562.
35. Fraternale A, Rossi L., and M.Magnani. Encapsulation, Metabolism, and Release of 2-Fluoro-Ara-AMP from Human Erythrocytes, Biochim.Biophys. Acta.1996; 1291(2):149–154.
36. R. Baker. Entry of Ferritin into Human Red Cells during Hypotonic Haemolysis, Nature, 1967; 215: 424–425.
37. X. Zhou and T. R. Graham. Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast Proc. Natl. Acad. Sci.USA 2009; 106: 16586-16591
39. Magnani M. et al. Acetaldehyde Dehydrogenase-Loaded Erythrocytes as Bioreactors for Removal of Blood Acetaldehyde, Alcoholism, Clin. Exp. Res.1989; 13:849–859.
40. H.O. Alpar and W.J. Irwin. Some Unique Applications of Erythrocytes as Carrier Systems, Adv. Biosci. (Series) 1987; 67: 1–9.
41. Gothoskar AV. Resealed erythrocytes: a review, Pharmaceutical Technology 2004; 1: 140-158.
42. Vyas S. P. ; Naresh Talwar ; Karajgi J. S. ;Jain N. K. An erythrocyte based bioadhesive system for nasal delivery of propranolol , Journal of controlled release, 1993; (23): 231-237.
43. R Green, J Miller and W Crosby Enhancement of iron chelation by desferrioxamine entrapped in red blood cell ghosts, The American Society of Hematology 57( 5), 866-872 .
44. B. C. Pressman, Biological Applications of Ionophores, Annual Review of Biochemistry, (45): 501-530.
45. J. Cuppoletti et al. Erythrosomes: Large Proteoliposomes Derived from Cross- Linked Human Erythrocyte Cytoskeletons and Exogenous Lipid, Proc. Natl. Acad. Sci. 1981; 78(5): 2786–2790.
46. S.P. Vyas and V.K. Dixit, Pharmaceutical Biotechnology 1 (CBS Publishers & Distributors, New Delhi). 1999:655.
47. M. Moorjani et al. Nanoerythrosomes, A New Derivative of Erythrocyte Ghost II: Identification of the Mechanism of Action, Anticancer Res. 1996; 16 (5A): 2831– 2836.
48. A. Lejeune et al. Nanoerythrosomes, A New Derivative of Erythrocyte Ghost: III. Is Phagocytosis Involved in the Mechanism of Action, Anticancer Res. 1997: 17- 5.

Search

Resealed Erythrocytes- As a Carrier

RECOMMENDED POSTS

Subscribe with us

Jobs by Category