History of Cationic vs Anionic: in nasal drug delivery system

MAY 2014 ARTICLE LIST >>

PharmaTutor (May- 2014)
ISSN: 2347 - 7881

Received On: 08/03/2014; Accepted On: 23/03/2014; Published On: 01/05/2014

Author: Manu Sharma¹, Shikha Chaudhary¹, Dharmendra Kumar²*
¹R.V.Northland institute, greater Noida, Dadri, UP, India
²Brahmanand Group of Institution, Khurja G.T Road, Buldshahar, Uttar Pradesh, India.
*rvnimiet@gmail.com

ABSTRACT:
Chitosan as cationic and pectin as anionic are natural polysaccharides which show great potential in nasal drug delivery system. Chitosan’s are strongly poly-cationic. They are derivatives of poly-N-acetyl-D-glucosamine. Chitosan’s have positive charge that is responsible for mucoadhesion and play an important role in nasal drug delivery system Pectin’s have several structural elements: Homogalactouronan are smooth and Rhamnogalactouronan are hairy which play a very important role. By methyl esterifications, pectin’s are divided in two types: High methoxypectin’s and low methoxypectin’s. Low methoxypectin’s are very important in the formulation of nasal gel, because they have properties to form the gel with calcium ion (Ca²⁺).

How to cite this article: M Sharma, S Chaudhary,D Kumar; History of Cationic Vs Anionic: in nasal drug delivery system; PharmaTutor; 2014; 2(5); 104-107

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