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Analytical Method Development and Validation for Simultaneous Estimation of Tolperisone Hydrochloride and Diclofenac Sodium in Bulk and Pharmaceutical Formulation

 

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JAN 2015 ARTICLE LIST >>

PharmaTutor (January- 2015)

 

ISSN: 2347 - 7881
(Volume 3, Issue 1)

 

Received On: 09/11/2014; Accepted On: 20/11/2014; Published On: 01/01/2015

 

AUTHORS: Akash M Patel*, Nirav N Patel, Prakash A Sathwara
*Faculty of Pharmacy, Dharmsinh Desai University,
Nadiad, Gujarat
Aku.pharmacy@gmail.com

 

ABSTRACT: Quantitative analysis of any drug is an important tool in an industry. It is important to determine that the raw material, intermediate products as well as final products meet its specifications and are of required quality. The number of drugs and drug formulations introduced into the market has been increasing at an alarming rate. These drugs or formulations may be either new entities or partial structural modification of the existing ones or novel dosage forms.

Spectrophotometry and HPLC methods are considered to be most suitable for estimation of the drugs present in pharmaceutical dosage forms.

· Literature review reveals that several spectroscopic and Chromatographic method have been reported for estimation of TOL and DIC alone as well as with other drugs.
· Simultaneous equation, dual wavelength difference UV spectrophotometry and First derivative spectroscopic method is available for this combination.
· The aim of work is to develop and validate cost effective First derivative method in water and RP-HPLC method for simultaneous estimation of TOL and DIC in bulk and Tablet dosage form.
· Development of UV spectrophotometric method.

 

How to cite this article: AM Patel, NN Patel, PA Sathwara; Analytical Method Development and Validation for Simultaneous Estimation of Tolperisone Hydrochloride and Diclofenac Sodium in Bulk and Pharmaceutical Formulation; PharmaTutor; 2015; 3(1); 40-57

 

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