DEC 2014 ARTICLE LIST >>
PharmaTutor (December- 2014)
ISSN: 2347 - 7881
(Volume 2, Issue 12)
Received On: 30/09/2014; Accepted On: 09/10/2014; Published On: 01/12/2014
AUTHORS: Lakshmanarao.R*, Pavani Priya.G, Saikishore.V
Department of pharmaceutics,
Bapatla college of pharmacy, Bapatla-522101, India
rapakalakshmanarao@gmail.com
ABSTRACT: Microspheres are well accepted technique to control the drug release from the dosage form to improve bioavailability, reduce absorption difference in patients, reduce the dosing frequency and adverse effects during prolong treatment. The main objective of the present study is to prepare and evaluate ibuprofen microspheres by solvent evaporation method, with water insoluble polymers such as Ethyl cellulose and sodium carboxymethyl cellulose as suspending agent, using as carrier for oral administration in view to achieve oral sustained release of the drug. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) used for relief of signs and symptoms of rheumatoid arthritis, osteoarthritis and is used in chronic and acute conditions of pain and inflammation. Its biological half-life is 2 ±0.5 hrs. Due to its low biological half-life (2 hrs), it requires frequent administration to maintain plasma concentration. This causes inconvenience to the patient and also leads fluctuations in plasma drug concentration that may cause inferior therapeutic effects or toxic effects. There-fore, development of controlled release dosage forms would clearly be beneficial in terms of decreased dosage requirements, thus increase patient compliance. The formulations were evaluated for particle size distribution analysis, flow properties like Angle of repose, bulk density, tapped density, Hausner’s Ratio, Carr’s index, Encapsulation efficiency, Scanning electron microscopy, optical electron microscopy and invitro release studies. The optimized formulation showed good invitro sustained release activity of the drug ibuprofen.
How to cite this article: R Lakshmanarao, PG Pavani, V Saikishore; Formulation and In Vitro Evaluation of Ibuprofen Loaded Ethyl Cellulose Microspheres; PharmaTutor; 2014; 2(12); 123-130
[ABSTRACT WITH CITATION] [VIEW AS HTML]
REFERENCES:
1. Indian Pharmacopoeia, Vol II, Govt. of India, Ministry of Health & Family Welfare, New Delhi,The controller of Publications,2010; 1479-83.
2. Tripathi K D. NSAIDs. In, Tripathi K D(ed). Essentials of Pharmacology, 6th edition, New delhi, Jaypee Publication,;184-201
3. T.Sudhamani, K. Noveenkumar reddy, V.R. Ravi Kumar, R.Revathi1, V. Ganesan. Preparation and evaluation of ethyl cellulose micro spheres of ibuprofen for sustained drug delivery: International Journal of Parma Research and Development – Online Publication Ref 2010/PUB/ARTI/VOV-2/ISSUE-8/OCT/019: page no: 119.
4. Jignesh P. Raval, Deep R. Naik and Pradip S. Patel. Preparation and evaluation of cellulose acetate butyrate micro spheres containing diclofenac sodium: International journal of drug formulation and research: Ravaletal. / IJDFR.2011; volume 2 Issue 4: page no: 348.
5. Prasanth v.v 1, Akash Chakraborthy Moy2, Sam T Mathew3, Rinku Mathapan4, Microspheres - An Overview ,International Journal of Research in Pharmaceutical and Biomedical Sciences,2011;Vol.2(2) :page no:335.
6. Shagufta Khan, Tripti Tiwari, Neha Rao, Amit Joshi, Bal Krishna Dubey. Microspheres : world journal of pharmacy and pharmaceutical sciences,2012; Volume 1, Issue 1: 125-145.
7. Alagusundaram.M, Madhu Sudana Chetty.C, Umashankari.K, Attuluri Venkata Badarinath, Lavanya.C and Ramkanth.S, Microspheres as a novel drug delivery system : International Journal of ChemTech Research,2009;Vol.1,No.3: pp 526-534.
8. Muniyandy Saravanan, Kesavan Bhaskar, Gomathinayagam Maharajan, and Kalathil Sadasivan Pillai, Development of gelatin microspheres loaded with diclofenac sodium for intra-articular administration: Journal of Drug Targeting, 2011; 19(2): 96–103.
9. Chinna Gangadhar B, Shyam Sunder R, Vimal Kumar Varma. M., Sleeva Raju M, Sai Kiran M.3, Formulation and Evaluation of Indomethacin Microspheres using natural and synthetic polymers as Controlled Release Dosage Forms: International Journal of Drug Discovery,2010; Volume 2, Issue 1: pp-08-16.
10. Parul Trivedi, AML Verma, N Garud. Preparation and characterization of Aceclofenac Microsphere. Asian Journal of Pharmaceutics. April 2008; 2(2): 110-115.
11. Gohel MC, Amin AF. Formulation and optimization of controlled release diclofenac sodium microspheres using factorial design. J Control Release, 1998; 51: 115-122.
12. Kumar R, Gupta R.B, Betageri G.V. Formulation, characterization, and in vitro release of glyburide from proliposomal beads. Drug Delivery. 2001; 8:25-27.
13. Lin WJ and Wu TL. Modification of the initial release of a highly water soluble drug from ethyl cellulose microspheres prepared by emulsion solvent evaporation method. Journal of Microencapsulation. 1999; 16: 639-646.
14. Haznedar S and Dortune B, Preparation and in vitro evaluation of Eudragit microspheres containing Acetazolamide, International Journal of Pharmaceutics.2004; 269: 131-140.
15. Chalk J.B., Patterson M., Smith M.T., Eadie M.J. Correlations between in vitro dissolution, in vivo bioavailability and hypoglycemic effect of oral Glibenclamide. European Journal of Clinical Pharmacology.1986; 31:177-82.
16. Dashora, K.; Saraf, S.; Saraf, S., Effect of processing variables and in-vitro study of microparticulate system of nimesulide. Rev. Bras. Cienc. Farm.2007; vol.43: no.4.
.png)
