Success Stories of Enolate Form of Drugs

PharmaTutor (December- 2013)
ISSN: 2347 - 7881

Received On: 13/11/2013; Accepted On: 23/11/2013; Published On: 20/12/2013

Authors: Arvind Negi¹, Balraj Singh Gill²
¹ Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda- 151001
² Centre for Biosciences, Central University of Punjab, Bathinda-151001

ABSTRACT: Stereochemistry of clinical agents play a key role in their success to become drugs. Tautomerism is a structural isomerism, playing a key role in the orientation of organic compounds and also found significant in distinctive base pairing in nucleic acids. Keto-enol form usually occurs and found prominently among different types of tautomers. The enolform ionizes in the physiological solution into enolate and alter the biological activity. So, how this enolate form brings modification in pharmacokinetics and pharmacodynamics of a drug is very important and quite interesting to know. As this form is ionic in nature so it increases the interaction with the concerning receptors, enzymes, ion channels or functional proteins. In this review we cover and compile success, role and the significance of the enolate form of clinical agents which succeed to become drugs!

How to cite this article: Negi A, Gill BS, Success Stories of Enolate Form of Drugs, PharmaTutor, 2013, 1(2), 45-53

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