Pyrimidine and Its Biological Activity: A Review

PharmaTutor (December- 2013)
ISSN: 2347 - 7881

Received On: 22/11/2013; Accepted On: 26/11/2013; Published On: 20/12/2013

Authors: Vishwanadham Yerragunta, Prathima Patil, V.Anusha, T.KumaraSwamy, D.Suman, T.Samhitha
Department of Pharmaceutical Chemistry,
Malla Reddy College of Pharmacy,
Maisammaguda, secunderabad-14. A.P.

ABSTRACT: Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six- member ring shows wide range of biological activities. Pyrimidine possess wide spectrum of biological activities like including anti-tubercular, anti-bacterial, anti-fungal, anti-viral, antiinflammatory, Anti-malarial activity, anti-cancer and anti-neoplastic activity, anti-hiv activity. The present reviews attempted to gather the various biological activities of pyrimidine derivatives and is marketed drugs.

How to cite this article: Yerragunta V, Patil P, V.Anusha, T.KumaraSwamy, D.Suman, T.Samhitha, Pyrimidine and Its Biological Activity: A Review, PharmaTutor, 2013, 1(2), 39-44

[ABSTRACT WITH CITATION] [VIEW AS HTML]

REFERENCES:
1.Gilchrist, Thomas Lonsdale; Gilchrist, T. L. Heterocyclic chemistry. New York: Longman., 1997.
2. Lagoja, Irene M. "Pyrimidine as Constituent of Natural Biologically Active Compounds". Chemistry and Biodiversity, 2007, 2 (1): 1–50
3. Patel, R.; Desai, K.; Chikhalia, K. J. Ind. Chem. Soc., 2003, 80 , 138.
4. Desai, K.; Patel, R.; Chikhalia, K. J. Ind. Chem., 2006 45 (B), 773.
5. Amr, A.E., Nermien, M.S., Abdulla, M.M. Monatsh. Chem. 2007., 138, 699.
6. Fujiwara, N., Nakajima, T., Ueda, Y., Fujita, H., Kawakami, H. Bioorg. Med. Chem. 2008, 16, 9804.
7. Ballell, L., Field, R.A., Chung, G.A.C., Young, R.J. Bioorg. Med. Chem. Lett. 2007, 17, 1736.
8. Wagner, E., Al-Kadasi, K., Zimecki, M., Sawka-Dobrowolska, W. Eur. J. Med. Chem. 2008, 43, 2498.
9. Cordeu, L., Cubedo, E., Bandres, E., Rebollo, A., Saenz, X., Chozas, H., Victoria Domínguez, M., Echeverria, M., Mendivil, B., Sanmartin, C. Bioorg. Med. Chem. 2007, 15, 1659.
10. Gorlitzer, K., Herbig, S, Walter, R.D. Pharmazie 1997, 52, 670.
11. Ukrainets, I.V.; Tugaibei, I.A.; Bereznykova, N.L.; Karvechenko, V.N.; Turov, A.V. Chemistry of Heterocyclic Compounds 5, 2008, pg-565.
12. Kurono, M.; Hayashi, M.; Miura, K.; Isogawa, Y.; Sawai, K. Sanwa Kagaku Kenkyusho Co., Japan , KokaiTokkyoKoho, Chem. Abstr., 1988.
13. Wang, S.Q.; Fang, L.; Liu, X.J.; Zhao, K. Chinese Chem. Lett. 2004, 15, pg-885.
14. C Frederick, B Philippe, B Elizabeth, KB Krista, C Huifen, GD Antonia, AE Jennifer, FTK Michael, L Kevin, L Cristina, L Lichuan, QL Cuong, M Shiva, N Jim, FO Daniel, P Zhonghua, DR Kirk, S Steve, T Lan, T Tom, W Jiansheng, Z Xianrui, PL Joseph, J. Med. Chem. 2011, 54(9), 3426-3435.
15. J. B. Dickey and A. R. Gary, Org. Syntch. Coll. 1943, Vol., 2, 62.
16. C. H. Lee, M. Jiang, M. Cowart, M. F. Jarvis and S. S. Bhagwat, J. Med. Chem., 2001, 44, 2133.
17.D. L. Boyle, E. A. Kowluk, M. F. Jarvis, C. H. Lee and S. S. Bhagwat, J. Pharmacol. Exp. Ther., 2001, 495, 296
18. O. Bruno, S. Schenone, A. Ranise, F. Bondavalli, W. Filippelli and F. Mazzeo, II Farmaco, 1999, 54, 95.
19 .A. Sacchi, S. Laneri, F. Arena, E. Luraschi and F. Rossi, Eur. J. Med. Chem., 1997, 32, 677.
20. P. Libert and J. B. Stanbury, Annu. Rev. Pharmacol., 1971, 11, 113.
21. H. B. Cottom, D. B. Wasson, H. C. Shih, G. D. Pasquale and D. A. Carson, J. Med. Chem., 1993, 36, 3424.
22. P. Calabresi and R. E. Parks, Jr. in 'The Pharmacological Basis of Therapeutics ed.’ L. S. Goodman and A. Gilman, Macmillan, New York, 5th ed., 1975, 1254.
23. M. S. El-Gaby, S. G. Abdel-Hamide and M. M. Gharab, Acta. Pharm., 49 (3), 149 (1999); Chem. Abstr, 132, 93278d, 2000.
24. P. Molina; E. Aller, A. Lorengo, P. L. Cremadis, I. Rioja and M. J. Alcaraz, J. Med. Chem., 2001, 44, 1011.
25. S. S. Bahekar and D. B. Shinde, Acta Pharm., 2003, 53, 223.
26. O. Bruno, C. Brullo; A. Ranise, S. Schenone, S. Bondavalls, M. Tognolini and M. Impicciatore, Bioorg. Med. Chem. Lett., 2001, 11, 1379.
27. Jones, M. E., Annu. Rev. Biochem., 1980, 49, 233–279
28. O Yuga, M Naoki, O Kengo, T Terufumi, I Hidehisa, A Yoshiko, M Hiroshi, H Akira, K Keiji, I Shinichi, Bioorg. Med. Chem. 2010, 18 (20), 7260-7273.

Search

Pyrimidine and Its Biological Activity: A Review

RECOMMENDED POSTS

Subscribe with us

Jobs by Category