Founded in 1614, the University of Groningen enjoys an international reputation as a dynamic and innovative institution of higher education offering high-quality teaching and research. Flexible study programs and academic career opportunities in a wide variety of disciplines encourage the 30,000 students and researchers alike to develop their own individual talents. As one of the best research universities in Europe, the University of Groningen has joined forces with other top universities and networks worldwide to become a truly global center of knowledge. The Groningen Research Institute of Pharmacy closely collaborates with the Groningen Research Institute for Asthma and COPD of the University Medical Center Groningen.
Job description
Funded by the Lung Foundation Netherlands, a consortium of the University of Groningen (RUG), the Amsterdam Medical Center (AMC) and Oxford University is looking for two PhD candidates (one stationed at the RUG and one at the AMC) with an interest in translational research in the field of Respiratory Medicine. The consortium project will investigate the effects of oxidative stress on macrophage function in order to predict an/or prevent exacerbations of asthma and COPD.
Job description for the PhD position at RUG
This part of the project is devoted to testing novel therapeutic strategies to relieve oxidative stress in lung tissue to investigate whether this dampens exacerbation severity in animal models of asthma and COPD. The project involves mouse models of house dust mite-induced asthma and cigarette smoke-induced COPD combined with influenza infection. Transcriptome analysis of macrophages isolated from lung tissue of these models will be done in collaboration with the University of Oxford to identify possible new drug targets.
Job description for the PhD position at AMC
In this part of the project sputum and bronchoalveolar lavage macrophages are characterized phenotypically and functionally before and after an experimental rhinovirus16-induced exacerbation in patients compared to controls. The studies are aimed at clarifying why patient’s macrophages, in contrast to those from healthy controls, will respond differently to reactive oxygen species and how that affects the subtypes of macrophages and their function. Transcriptomics will be performed in collaboration with the University of Oxford.
Qualifications
Qualifications for both positions
We are looking for enthusiastic and talented Ph.D candidates with:
• a master in Medical Biology, Pharmacy, Pharmaceutical sciences, Health Sciences or similar disciplines
• experience in immunological, cell biological, molecular (gene expression analysis) and/or histological techniques
• the ability to work within an interdisciplinary team
• fluency in English language
• for the position at RUG experience with animal research (art.9) is preferable.
Conditions of employment
We offer full time PhD positions with a salary of about € 2,146 gross per month in the first year up to a maximum of about € 2,744 gross per month in the fourth year. The Graduate Schools at RUG and AMC offer excellent doctorate training programs.
The preferred starting date for both positions is 1 January 2016.
Apply
You can apply for these positions until 15 November / before 16 November 2015 by using the application form, click on "Apply" below on the advertisement on the university website. Clearly state for which position you are applying by stating “RUG” or “AMC” on your application form. Interested applicants must submit a letter of motivation and a curriculum vitae. Please supply the names and contact information of at least two references in your curriculum vitae.
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