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WONDERS OF IMMUNE SYSTEM: SPONTANEOUS REGRESSION OF CANCERS

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About Author
Vishwas B. Chavan
Consultant, Sunflower laboratory and diagnostic Center and Clinical Diagnostic Center
Mumbai, Maharashtra.
vishwaschavan2003@yahoo.co.in

Cancer incidence is increasing worldwide [1]. It can affect any part of the body, showing symptoms often in late stages. Diagnosis of cancer has a huge impact on patient and his/her family. Cancer treatments are costly and toxic, many times giving rise to secondary cancers. Even after successful treatment, risk of recurrence of cancer is significant sometimes.


A REVIEW ON DYSLEXIA

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ABOUT AUTHORS:
S.Ramyasilpa
Department of pharmacology,
Nargund college of pharmacy, Bengaluru
shilpasankarapu@gmail.com

ABSTRACT
Dyslexia is a specific reading disorder. It is common childhood disorder affecting around 5% of school aged children. The main deficits of dyslexia include inability to process sensory input (i.e., acoustic information) that comes into the nervous system rapidly, and an impaired reading ability. Secondary consequences may include problems in reading comprehension and reduced reading experience that can impede growth of vocabulary and background knowledge. The dyslexia is associated with alteration of several biological levels like genetic, biochemical, physiological, cognitive levels.


CLINICAL PHARMACY IN INDIA: RECENT ADVANCES AND PERSPECTIVE

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ABOUT AUTHORS:
Mazhar M1, Ansari. A2, Rajput SK1*
1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201313.
2Department of Social Work, University Road, University of Delhi, Delhi-110007.
*skrajput95@amity.edu

ABSTRACT
In lieu of the fact that without adequate supervision, the assurance of quality of any system is not possible; clinical pharmacy has emerged as one of the latest and unmapped discipline of pharmacy in the 21st century. The existence of clinical pharmacists in medical rounds could support physicians in optimizing pharmacotherapy. This novel profession in India extends its diversions to good manufacturing practices, procurement/preparation/distribution of medication, reporting ADRs/ ADEs and on the whole to a very promising aspect of patient healthcare service. The state of clinical pharmacy in India is in the transformational state showing serious positive promising changes in the past couple of years. Even hospitals have started distinguishing the importance of clinical pharmacy and have taken initiatives for making it possible although at a budding stage. The clinical pharmacy branch of pharmacy is surely attaining new heights in regard to patient care services which have certainly increased the services and satisfaction to the patients.


CHILDHOOD OBESITY: REASON BEHIND THIS HEALTH CRISIS

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ABOUT AUTHORS:
Abhinav Sawhney*, Nidha Amir, Mohd Mazhar, Sumeet Gullaiya, Satyendra K Rajput
Department of Pharmacology,
Amity institute of Pharmacy, Amity University,
Noida, Uttar Pradesh
abhinavsawhney@live.com

ABSTRACT:
Obesity has emerged as a major health issues for pediatric population as well as in adults in the present global scenario. In children, numerous studies have reveiled a relationship between the breast feeding and obesity in children. Apart from these, Family economic and education level, child meal pattern, duration of sleep and birth weight are also responsible for obesity. Some genetic problems including environmental and socio-economic factors are also responsible for the child obesity. Several studies have shown an evidence of protective effect of breast feeding against obesity while some shows a time dependent effect of breast feeding on childhood obesity. As per WHO recommendations, a child should be exclusively breast fed upto 6 months and breast fed along with the complementary food of good quality.  Introduction of the complementary food has a relationship bound with adipose rebound, which goes upto the age of 14. The intake of complementary food reduces the intake of breast milk and also induces the allergic reactions in the child. Apart from these leptin level and energy regulation in the body also plays and important role in pediatric obesity.


SYSTEMATIC APPROACH FOR COMPLAINT HANDLING IN PHARMACEUTICAL INDUSTRIES- AN UPDATED REVIEW

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ABOUT AUTHORS:
Jadhav Santosh*, Mali Audumbar, Bathe Ritesh, Tamboli Ashpak, Sawale Jyotiram
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
This article covers fundamental basics of quality complaint.Complaints show customer dissatisfaction about the quality of a pharmaceutical Product. Complaints may be about: Services, delivery, quality of product, communication, response time, documentation, billing, follow up etc. a good complaint handling system gives the company an opportunity to improve the quality of their products, being a good tool for the maintenance of Good Manufacturing Practices. A systematic procedure must be developed and implemented in order to register and investigate each complaint received and not only the Quality Assurance area must be involved. Systematic handling of complaints maintains a good relationship between customer and company. Thus the aim of this article is to discuss the main steps of a good complaint handling procedure that can be readily implemented in pharmaceutical companies.


CHRONOPHARMACOTHERAPY OF HYPERTENSION: TIME-DEPENDENT EFFECTS OF TREATMENT ON BLOOD PRESSURE

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ABOUT AUHTORS:
Suresh Rewar1*, Bansal BK1, Singh CJ2, Sharma AK2
1Department of pharmaceutics, Arya College of Pharmacy, Jaipur, Rajasthan India
2Department Of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan India
sureshrewar1990@gmail.com

ABSTRACT
Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, right time and right amount, as per the pathophysiological needs of the diseases. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. These systems are designed for chronopharmacotherapy which is based on the circadian rhythm of the body. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr. rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. The chronobiology of the various common 24-hour BP profiles seen in hypertensive patients in relation to cardiovascular risk and end-organ injury and ultimately the control and normalization of abnormal BP throughout daytime activity and night time sleep. Chronopharmacotherapy provides a means of individualizing the treatment of hypertension according to the circadian BP profile of each patient, and constitutes a new option to optimize BP control and to reduce the risk of cardiovascular disease. Various latest and upcoming marketed technologies of Chronopharmaceutical drug delivery used in treatment of hypertension diseases like OROS®, CODAS®, CEFORM®, DIFFUCAPS®, PULSINCAP® etc.


A CASE STUDY ON HEMOLYTIC UREMIC SYNDROME- LEADING TO ACUTE RENAL FAILURE

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ABOUT AUTHORS:
Jiguru Prasant*, Mohammad Kaleemullah Quraishi, Amer Khan
Department of Doctor of Pharmacy,
Krishna Institute of Medical Sciences and Bharat Institute of Technology (Pharmacy),
Hyderabad, Telangana, India
Prashant7792@gmail.com

ABSTRACT
A 65 yrs female patient was presented with  complaints of vomiting,  loose stools, pain,  fever, high grade chills,  giddiness, loss of appetite acute renal failure, hemolytic anemia and thrombocytopenia She was diagnosed with Escherichia coli  associated hemolytic-uremic syndrome and treated with plasmapheresis and other medications for 3 weeks. She recovered without sequelae.


TARGETED DRUG DELIVERY SYSTEMS FOR LUNG CANCER

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ABOUT AUTHORS:
Abdul Waheed1*, Ankit Gupta2, Parth Patel3
1Department of Pharmacology
2Department of Pharmaceutics
3Department of Drug Regulatory Affair
Amity Institute of Pharmacy, Amity University, Noida-125, U.P. (INDIA)
abdul.waheed2050@gmail.com

ABSTRACT
In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity. Pulmonary epithelial cell, enzymes, receptors and genes are the target of the targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer.


NEED AND APPLICATION OF ANALYTICAL METHOD DEVELOPMENT ON NEW FIXED DOSE COMBINATION OF IRBESARTAN AND ATORVASTATIN IN PHARMACEUTICAL INDUSTRY

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ABOUT AUTHORS:
Paras Virani1,2*, Parul Jain3, Hasumati Raj2, Vineet Jain2
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality assurance department, Shree Dhanvantary Pharmacy College, Kim, Surat
3Quality assurance department, Maliba Pharmacy College, Bardoli, Surat
parasvirani@gmail.com

ABSTRACT
Analytical method is primary requirement of the pharmaceutical industry. In pharmaceutical industry various analytical methods is used like chromatography, spectroscopy method, electrochemical method, ion incorporating method, etc. Irbesartan is classified as an angiotensin II receptor type 1 antagonist. Angiotensin II receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Atorvastatin is the most efficacious of the currently available HMG-CoA Reductase inhibitors used in anti lipidemic and also used in atherosclerosis, stroke and cardiac risk. In recently approved new fixed dose combination of Irbesartan and atorvastatin in market of Korea so it require analytical method development which help in industry for new drug delivery system development. This review highlights the role, need and application of various analytical techniques for Irbesartan and atorvastatin combination and their corresponding analytical methods in the pharmaceutical industry.


REVIEW: PLAGIARISM AN ACT OF UNETHICS

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ABOUT AUTHORS:
Anuradha Sharma1*, Vaibhav Walia2, Monika Gahlawat3
1Division of Pharma. Chemistry, 2Division of Pharmacology, 3Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

ABSTRACT
Plagiarism is a multifaceted and ethically a complex problemwhich simply means the stealing and publication of another author’s work as one's own original work without acknowledge the original author. Plagiarism is simply an act of fraud.Authors should acknowledge sources fully and appropriately to follow the ethics and plagiarism is failure to do so. However the students or the authors sometimes fail to acknowledge the source appropriately and properly. These failures are largely due to the lack of knowledge to use the citations properly. Therefore to maintain the ethics the plagiarism should be avoided. The aim of this paper is to define plagiarism, its type, methods of detection and the ways to avoid plagiarism.