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DEVELOPMENT AND VALIDATION OF IR SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF AZELASTINE HYDROCHLORIDE IN NASAL SPRAY PREPARATIONS
*1Patel Rina B., 2Patel Nilam K.
1M.pharm(Q.A), Department of Pharmaceutical Sciences
Hemchandracharya North Gujarat University,
2Asst. Professor, Dept. of Pharmaceutical Sciences
Department of Pharmaceutical Sciences, Hemchandracharya North Gujarat University, Patan. Gujarat-384265
A simple, sensitive, rapid, accurate, precise and economical Fouriertransform infrared (FTIR) spectrophotometric method has been developed for the determination of Azelastine Hydrochloride (AZH) in nasal spray preparations. The IR spectrophotometric method was based on the determination of AZH by the measurement of the area of the infrared band corresponding to the carbonyl group centred at the band1636 cm-1. It was present in the AZH but not in Acetonitrile used as solvent and highest intensity was at the area 1701.08-1584.21 cm-1. The linearity of AZH was obtained in the concentration range of 5-100 μg/ml. The mean % recovery was 99.67 ± 0.57 %. The recovery studies confirmed accuracy of proposed method and low values of standard deviation confirmed precision of method.
Dr. D.k. Sanghi, Rakesh Tiwle*, Puja Karanjekar, Priyanka Hemne, Dileshwari Madavi, Padma Tembhre
Shri Laxmanrao Mankar Institute of Pharmacy,
Amgoan, Gondia, Maharashtra, India- 441902.
A pharmaceutical formulation and its research invasis play important role in the young generation of the pharmacy students because without seeing the process we don’t know about the formulation and development of any medicine because of that a industrial visit should be compulsory to the pharmacy students. Pharmaceutical industry is a most diverse, R&D oriented, hypercompetitive and knowledge sensitive industry. Competitive intelligence (CI) is a process of ethically and systemic data gathering from operating system to draw important business conclusions. Use of CI for drawing important conclusions regarding present scenario and future forecasting is very important and growth determining practice of pharmaceutical industries. Intellectual property rights (IPR) is an integral part of the industry and IPR related information is freely available in public patent databases. By analyzing patents company can derive important conclusion regarding competitor’s R&D activities, quality of research, collaboration and alliance and can convert this information to knowledge which can play important role in taking future decisions. Present review is fully focused on advent of IPR in getting very good information regarding competitor’s strategies and tactics.
Rakhi Choudhary*, Lakshmi Goswami , Preeti Kothiyal
Shri Guru Ram Rai Institute of Technology & Science P.O. Box - 80, Patel Nagar,
Dehradun 248001, Uttarakhand , India
Major depression is a mood disorder characterized by a sense of inadequacy, despondency, decreased activity, pessimism and sadness where these symptoms severely disrupt and adversely affect the person’s life, sometimes to such an extent that suicide is attempted or results. Various Strategies are used for the treatment of depression by giving drug by various routes. Nasal drug delivery is the best route for treatment of CNS disorder as it is the direct route for the delivery of drug.
M.V. Chavan1*, T.T.Mahajan2, M.B. Chaudhari1, N.N.Chavan1
1H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, District-Dhule (M.S), India.
2R.C.Patel Institute of Pharmaceutical Education and Research, Shirpur, District-Dhule (M.S), India
In present work mixed solvency concept was used for solubility enhancement of poorly water soluble drug. Aqueous blends of hydrotropes, cosolvents and water soluble solids were used as solvent for poorly water soluble model drug zaltoprofen. In mixing solvency above additives are mixed in different ratio and their aqueous solution served as solvent for water insoluble drug. These solvent systems have extreme potential of increasing solubility of poorly water soluble drugs. In this research work standard curve of drug in different individual aqueous solution of above mentioned type of substances as well as in their blend were plotted and from the curve, solubility of drug in that solvent system is estimated using excess solute addition method. The results obtained shows that solubility of drug in mixed blend is more as compared to their individual solvent systems.
Department of pharmacology
Teegala Ram Reddy College of Pharmacy
Hyderabad (AP), 500097.
Lyme disease (Lyme borreliosis) is an infectious disease caused by at least three species of bacteria belonging to the genus Borrelia. Borrelia burgdorferi sensu strictois the main cause of Lyme disease in North America, whereas Borrelia afzelii and Borrelia garinii cause most European cases. The disease is named after the towns of Lyme and Old Lyme, Connecticut, US, where a number of cases were identified in 1975. Although it was known that Lyme disease was a tick-borne disease as far back as 1978, the cause of the disease remained a mystery until 1981, when B. burgdorferi was identified by Willy Burgdorfer.
Lyme disease is the most common tick-borne disease in the Northern Hemisphere. Borrelia is transmitted to humans by the bite of infected ticks belonging to a few species of the genus Ixodes ("hard ticks"). Early symptoms may include fever, headache, fatigue, depression, and a characteristic circular skin rash called erythema migrans (EM). Left untreated, later symptoms may involve the joints, heart, and central nervous system. In most cases, the infection and its symptoms are eliminated by antibiotics, especially if the illness is treated early. Delayed or inadequate treatment can lead to more serious symptoms, which can be disabling and difficult to treat.
Kanak Manjari Institute of Pharmaceutical Sciences
Andropause is an age-related decline of testosterone in men that is gaining recognition as the world population becomes more aged. The diagnosis is based on clinical signs and symptoms supported with laboratory confirmation of low serum testosterone levels. The benefit of testosterone replacement therapy (TRT) for andropause has been well documented, but it requires careful monitoring.
*Govind shukla1, Ms.Shivani prashar2, Ms. M.sarika3, Dr. Sunil Yadav4
1M.Pharm(Ph.D), Product Manager
2Sr. Product Executive, Shrey Nutraceuticals Pvt. Ltd. NewDelhi
3Product Analyst, Lactonova India Hyderabad
4Medical officer-in–charge, BPHC Bamore JHANSI U.P.
Nutrition before and during pregnancy has a profound effect on the development of infants. This is a rather critical time for healthy fetal development as infants rely heavily on maternal stores and nutrient for optimal growth and health outcome later in life. Prenatal nutrition addresses nutrient recommendations before and during pregnancy. Birth weight of the newborn at delivery reflects the sufficiency and the quality of maternal nutrient for the fetus during pregnancy. Prenatal nutrition has a strong influence on birth weight and further development of the infant.The present paper reviews the role of prenatal nutrition in pregnancy.
Khandelwal Pankaj, Chirag Sudani*, Parmar Jatin, Prashant Sanghavi, Shifalee Magazine
Mahatma Gandhi College of Pharmaceutical Sciences,
This review paper highlights the current advances in knowledge about the safety, efficacy, quality control and regulatory aspects of Phytopharmaceuticals. The growing use of Phytopharmaceuticals (drug and other products derived from plants) by the public is forcing moves to evaluate the health claims of these agents and to develop standards of quality and manufacture. At present there is almost no policy worth its name to regulate the procurement and sale of medicinal plants in developing countries. Finally, the trend in the domestication, production and biotechnological studies and genetic improvement of medicinal plants, instead of the use of plants harvested in the wild, will offer great advantages, since it will be possible to obtain uniform and high quality raw materials which are fundamental to the efficacy and safety of herbal drugs.It is clear that the herbal industry needs to follow strict guidelines and that regulations are needed. This paper presents the element of methods of different aspects on efficacy, safety, quality control and standardization of herbal drugs and formulation. It is followed by international guidelines of WHO for manufacture quality control and evaluation of botanicals. Herbal drugs regulations in India is discussed in detail, followed by an overview of regulatory status of herbal medicine in USA, China, Australia, Brazil, Canada and Germany.
G. Sowjanya*, P. Ramaa Bharathi, Dr.A.M.S.Sudhakar Babu
A.M.Reddy memorial college of pharmacy,
Film coating technology is now a days very important in the field of pharmacy particularly in formulation development. In the last 25 years tablet coating has undergone several fundamental changes. Many modifications were advocated to improve the basic process and film coating chosen in place of sugar coating. Film coating is the process whereby a tablet, capsule, or pellet is surrounded by a thin layer of polymeric material. Tablet film coating is performed by two types, one is aqueous film coating (generally water is used as a solvent) and non aqueous film coating (generally organic solvent are used). Film coating formulations usually contain Polymer, Plasticizer, Colourants / Opacifiers, Solvent / Vehicle. Many film coating materials have functional properties which enable the creation of sustained or delayed (enteric) release dosage forms. Coating solution composition may affect the quality of final coated tablets. Optimization of composition of film coating solution is also required. This article discusses tablet coating process, film coating, process parameters, film coating advantages and applications, components of film coating, evaluation of film coated tablets, film defects etc.
NOVEL RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF LOSARTAN POTASSIUM AND AMLODIPINE DRUGS IN PURE AND PHARMACEUTICAL DOSAGE FORMS
1Kumari Jyothsna*, 2N.Chandana
1,2Department of Pharmaceutical Analysis and Quality Assurance,
Nimra College of Pharmacy, Jupudi, Vijayawada, A.P, India
A fast, robust and accurate RP-HPLC method was developed and validated for simultaneous determination of Losartan potassium and Amlodipine in tablets. The mobile phase was mixture of aqueous Tri ethyl amine with pH 2.0 and Acetonitrile(70:30), effluent flow rate monitored at 1.0 ml/min. the stationary phase was C18 column, 3µm(4.6×250mm). The solutions of standard and the sample were prepared in methanol. The retention times was found to be 2.916min and 5.214min for Losartan potassium and Amlodipine respectively at 246nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of 50-150µg/ml. The percentage assay for Losartan potassium and Amlodipine were found to be 101% and 100%respectively. The method was validated and it was found to be accurate, precise, linear and reproducible as per ICH guidelines.