Articles

A RARE CASE REPORT ON TUBEROUS SCLEROSIS

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ABOUT AUTHORS:
N. Surendra Reddy, S. Chandrakala, B. Nagendra Prasad, G. Divya, T. S. Durga Prasad, Diviti Ranganayakulu
Department of pharmacy practice,
Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati, india
*suriph7@gmail.com

ABSTRACT:
Tuberous sclerosis is a neurocutaneous syndrome with an autosomal dominant inheritance. Tuberous sclerosis has an approximate incidence of one in ten thousand to fifty thousand. Tuberous sclerosis complex Syndrome (TSCs) is a dominantly inherited disorder affecting multiple organs; caused by mutations of either the TSC1 or TSC2 gene encoding hamartin and tuber in respectively. It is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas (angiofibromas), gingival hyperplasia and enamel hypoplasia and the formation of hamartomas in multiple organ systems leading to morbidity and mortality. It is important to make an early diagnosis of TSC so that lifelong monitoring, early recognition of complications and proactive treatment can lower the morbidity and mortality rates. We report a case of 35 year old female in south India with the features of Tuberous sclerosis complex like seizures, weakness of the body, papules over the cheek, calcification noted in subependymal region in the brain and angiomyolipoma in both kidneys.


IMPURITY PROFILING AN EMERGING TREND IN PHARMACEUTICALS: A REVIEW

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ABOUT AUTHORS:
*Abhijit Chanda1, N.Ramalakshmi2, C.N Nalini2, S. Mahabubi1
1Department of Quality Assurance, Baxter (India) Pvt. Ltd
2Dept. of Pharmaceutical Analysis, C. L. Baid Metha College of Pharmacy
Chennai-600097, Tamilnadu, India
chandaabhijit91@gmail.com

ABSTRACT
Impurity profiling brings tremendous efforts in the group of analytical activities, the aim of which is the detection, identification/structure elucidation and quantitative determination of organic and inorganic impurities, as well as residual solvents in bulk drugs and pharmaceutical formulations. The control of impurities is currently a critical issue to the healthcare manufacturing. Various regulatory authorities like ICH, USFDA, UK-MHRA, CDSCO are emphasizing on the requirements and the identification of impurities in Active Pharmaceutical Ingredient’s (API’s) and as well as finished products. International Conference on Harmonization (ICH) formulated guidelines concerning the control and limit of impurities. To isolate and characterize impurities in pharmaceuticals diverse methods are used such as, capillary electrophoresis, gas–liquid chromatography, high performance liquid chromatography, solid-phase extraction methods, Ultraviolet Spectrometry, infrared spectroscopy, supercritical fluid extraction chromatography, mass spectroscopy, Nuclear magnetic resonance (NMR) spectroscopy etc. On the beginning of hyphenated techniques, the most browbeaten techniques for impurity profiling are Liquid Chromatography (LC)-Mass Spectroscopy (MS), LCNMR, LC-NMR-MS, GC-MS and fully automated Comprehensive Orthogonal Method Evaluation Technology (COMET). That is why it has plentiful claim in the field of drug design, monitoring quality, stability and as well as safety of the product.


FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF FLOATING TABLETS OF CEFIXIME

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ABOUT AUTHORS:
B.Venkateswara Reddy
Department of Pharmaceutics,
St.Pauls College of Pharmacy, Turkayamjal (V),
Hayathnagar (M), R.R.Dist-501510, India.
basu.pharmacist@gmail.com

ABSTRACT:
Objective:
Cefixime is a third generation cephalosporin antibiotic having bactericidal activity by inhibition of cell wall synthesis and is used in the treatment of uncomplicated UTI, pharyngitis and tonsillitis, acute bronchitis and acute exacerbation of chronic bronchitis, uncomplicated gonorrhoea etc. The concept of formulating floating tablets containing Cefixime offers a suitable and practical approach in serving desired objective of retaining the drug in the stomach to increase the its bioavailability.
Methods:
The tablets were prepared by direct compression methodand total of 12 formulations are developedemploying HPMC K100M and HPMC K15M as polymers for sustaining the drug release and sodium bicarbonate as the gas generating agent.
Results:
Various polymers have been selected and subjected to IR-spectroscopic studies and found that there were no drug–excipient interactions. The powder blends of all the formulations have shown good flow properties. Other parameters such as hardness, friability, drug content uniformity, Floating lag time and in-vitro dissolution studies were performed and the results were satisfactory.
Conclusion:
Formulation F 12 was found to be best in all aspects and was considered as optimized formulation, it has a low floating lag time of  2mins  and has shown a maximum drug release of 99% at the end of 24 hours and drug release was by diffusion through the polymer matrix.


TAILOR-MADE MEDICINE: A STEP TOWARDS FUTURE OF DIAGNOSTICS AND THERAPEUTICS

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ABOUT AUTHORS
Vivek P. Chavda
Department of Pharmaceutics,
B.K. Mody Government Pharmacy College, Near Aji dem, Rajkot-Bhavnagar highway,
Gujarat technological university, Rajkot-360003, Gujarat (India)
vivek7chavda@gmail.com

ABSTRACT
The goal of tailor-made medicineis to maximize the likelihood of therapeutic efficacy and to minimize the risk of drug toxicity for an individual patient. It involves right drug & dose, right patient and at right time administration of a medication. By averting the knowledge of gene sequence and their functions, biomedical research are diversified towards inter-individual variations that are expected to become an eminent part of treatment planning in terms of efficacy and toxic side effects of drugs. tailor-made medicinefocuses on individualized drug treatment according to each patient’s molecular diagnosis and genetic makeup. Genomic-based diagnostics can play a key role in creating a more efficient healthcare system by directing patients toward beneficial therapies and away from therapies that pose substantial risk or are unlikely to improve outcomes for the patient.


PHARMACOTHERAPY CONSIDERATIONS IN PALLIATIVE CARE – A REVIEW

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ABOUT AUTHOR:
Akash kurian
Clinical Pharmacist,
PSG College of Pharmacy
akash.kurian8@gmail.com

ABSTRACT
Noncommunicable diseases (NCDs), such as heart disease, stroke, cancer, chronic respiratory diseases and diabetes, are the leading cause of mortality in the world. According to world health organization, In India The probability of dying between ages 30 and 70 years from the 4 main Non-Communicable Diseases (Cancers, Diabetes, Cardiovascular Diseases, Chronic Respiratory Diseases) is 26 %   in the year  2014 [1] .

The WHO defined palliative care as “an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial, and spiritual [2]. It has been considered both a general approach to patient care and a practice specialty. A palliative care approach can be applied at any point during the course of illness and should not be confused with hospice care, which incorporates the philosophies of palliative care, but is typically provided to patients with life expectancies of 6 months or less. The purpose of this review article is to focus on pharmacotherapy decisions of chronically ill patients during the later part of life and pharmacists responsibilities in hospice and palliative care.


CAREER AVENUES IN KNOWLEDGE PROCESS OUTSOURCING SECTOR-“With a Special Reference to Healthcare”

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ABOUT AUTHORS:
Nidhi Nigam
Indian Institute of Health Management and Research,

Jaipur, Rajasthan, India
dr.nigamnidhi19@gmail.com

ABSTRACT
KPO is latest wave to hit outsourcing business globally, booming sector with tremendous potential. It employs more then 25000 people currently. Worldwide KPO sector is expected to reach about US $17 billion by 2015, out of which US $12 billion will be the contribution made by India.KPO is claimed to be one step extension of BPO as it is advantageous and has lot of future scope. Developing rivalry among business units has constrained the firms to give operational proficiency and increase the value of their products and services.


RNA INTERFERENCE-WEAPON AGAINST CANCER

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ABOUT AUTHORS:
Shalja Verma, Anand Kumar Pandey*
Department of Biotechnology, Institute of Engineering & Technology,
Bundelkhand University, Jhansi, Uttar Pradesh, India
vnsanand_9@rediffmail.com

ABSTRACT
Cancer is the second principal death cause, in the recent scenario 1 out of every 4 people die out of cancer. Not more than 50% advanced cancer subjects live a year ahead. RNA interference (RNAi) a phenomenon which serves for shutting off the expression of a specific sequence has proved itself a finest weapon against cancer. This mechanism involves silencing of the expression of desired mRNA sequence by degrading it using a dsRNA (double stranded RNA) molecule having complementarity to the desired mRNA. However a major challenge in proficient implementation of this therapy against cancer is lack of efficient delivery methods for the dsRNA to the target tissue. Various delivery methods had already been developed for efficient and effective delivery of the dsRNA and many are under trial. This review is going to present the great efficacy of RNAi against cancer and the various delivery methods performing capable work in accurate application of this therapy.


BIOLOGICAL FUNCTIONS OF VITAMIN B COMPLEX AND EFFECTS ON HUMAN HEALTH IN BOTH EXCESS AND DEFICIENCY LEVELS

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ABOUT AUTHORS:
Amarjeet Kaur
Department of Pharmacy,
Guru Ram Das (PG) Institute of Management & Technology,
Dehradun, Uttarakhand, 248009, India.
amarjeetkaur069@gmail.com

ABSTRACT:
Vitamins are micronutrients and play vital role in healthy life. Body needs them in relatively small amounts, in comparison with other nutrients. Vitamins are two types on bases of their solubility viz. lipid soluble and water soluble. B vitamins or vitamin B complex are a group of water-soluble vitamins that play important roles in cell metabolism. These vitamins are chemically distinct vitamins that often coexist in the same foods. Individual B vitamin supplements are referred to by the specific name of each vitamin (e.g., B1, B2, B3, B5, B6, B7, B8, B9, B12 etc.). In general, supplements containing all eight vitamins are referred to as a vitamin B complex. B vitamins are found in whole unprocessed foods. Processed carbohydrates such as sugar and white flour tend to have a lower B vitamin than their unprocessed counterparts. Good sources for B vitamins include legumes (pulses or beans), whole grains, potatoes, banana, chilli peppers, tempeh, nutritional yeast, brewer’s yeast, and molasses. The vitamin B12 is of note because it is not available from plant products, making B12 deficiency a legitimate concern for vegetarians. Deficiency of B vitamins causes various diseases. Their deficiency may cause diseases viz.Vit. B1-Beriberi; Vit B2-Ariboflavinosis; Vit B3-Pellagra; Vit B5-acne; Vit B6-microcytic anaemia; Vit B7-CNS disorders; Vit B9–leucopaenia, macrocytic anaemia; Vit. B12­-Macrocytic anaemia, memory loss.


MBA Pharmaceutical Management- Opening New Frontiers for a Vibrant Career in Pharmaceutical Industry

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ABOUT AUTHORS:
Saurabh Kumar Banerjee
Assistant Professor, School of Pharmaceutical Management,
The IIHMR University, Jaipur, Rajasthan, India
saurabh@iihmr.edu.in

Pablo Picasso the famous Spanish painter, poet and playwright once quoted-
“Our goals can only be reached through a vehicle of a plan, In which we must fervently believe, and upon which we must vigorously act.
There is no other route to success”

In our journey for achieving excellence in professional career, meticulous planning and correct decision making, plays the most vital role in transforming our dreams and aspirations into reality. This piece of writing is an effort to give the reader an insight into the world of Pharmaceutical Management and help them to take a rational decision on the basis of facts and evidence, so that they can pursue a successful professional career in the area of Pharmaceutical Management.


THIN LAYER CHROMATOGRAPHIC STUDY OF THREE DIFFERENT EXTRACT OF Calendula officinalis LEAVES

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ABOUT AUTHORS:
Kuntal Pal1, Sampat Kumar Kundu2*, Manas Kumar Mandal3
1Manufacturing Chemist at Paharpur Ousadhalay, Kolkata, West Bengal, India.
2Research Scholar at Gurunanak Institute of Pharmaceutical Science & Technology, Sodepur, West Bengal, India.
3Consultant Urologist at AMRI Hospital, Kolkata
*sampatkundu001@gmail.com

ABSTRACT
Calendula officinalis
is a plant that possess many pharmacological actions like Stomach upset, Ulcer, Menstrual Period Problems, Eye Infections, Inflammation, Wound Healing, Anti-Septic etc. most widely it is used as wound healing purposes. If the leaf of that plant can be applied after crunching at the affected area, blood will be clot within a few time. But while this leaf can perform this action, it means it possess some active compound in it. To find out what the actual component it is, first we have to perform the Thin Layer Chromatographic study. In our present study we are going study the TLC profile of that Calendula officinalis leaf.


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