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RAPID AND SELECTIVE UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR DISSOLUTION STUDIES OF IVABRADINE CONTROLLED-RELEASE FORMULATIONS

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ABOUT AUTHORS:
Sagarika Panda1*, Srikanta Patra2
1 Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Andhra Pradesh, India;
2 National Institute of Pharmaceutical Education & Research (NIPER), Ahmedabad, Gujarat, India
*niperhsagarika@gmail.com

ABSTRACT
A highly sensitive, selective, reproducible, rapid and stability indicating RP-HPLC and spectrophotometric method has been developed and validated successfully for quantitative evaluation of ivabradine hydrochloride formulations. Chromatography was carried out at 25ºC on a 250 mm x 4.6 mm, 5µm, C18,  100Aº Kromasil column with phosphate buffer pH 7.4: methanol:: 35:65 and U.V. detector at λmax 286 nm. In HPLC method the retention time was about 7.4 minutes. Complete validation study for both the methods was carried out according to ICH guideline. Both methods were found to be selective, linear, accurate and precise in the specified ranges. Linearity of both the methods was achieved in the range 5 to 60 μg/ml with a correlation coefficient (r2) ≥ 0.999. The LOD and LOQ of HPLC method were 0.05 and 0.2 µg/ml, respectively. Intra-day and inter-day variability for both methods were <2% RSD. These methods were successfully used for quantification of ivabradine in drug-release studies from immediate-release tablets and controlled-release (CR) formulations.


IN VITRO EVALUATION OF ANTACID POTENTIAL OF CURCUMA LONGA LINN

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ABOUT AUTHORS:
DK Vir1*, Nandu Kayande1, Pankaj Kushwah2
1Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Dhar, Madhya Pradesh, India
*dkvir007@gmail.com

ABSTRACT
The study was aimed to evaluate the antacid properties of Curcuma Longa Linn rhizomes aqueous extract under simulated conditions. Fresh rhizomeof Curcuma Longa Linn was homogenized and dried under shade and thus mass obtained was powdered, weighed and subjected for the evaluation of antacid profile of the drug antacid properties of Curcuma Longa Linn was evaluated using carbondioxide evolution method & Rossette Rice test. The Curcuma Longa Linn rhizome extract showed significant results for antacid effect (P < 0.05) at different doses and the results obtained were comparable to that of standard NaHCO3. The results of the present study suggest that extract of  curcuma longa linn significantly neutralized acid and showed resistance against change in pH and also illustrate good antacid property The extract of curcuma longa linn, has shown to possess significant carminative and antacid property.


REVIEW ON DEVELOPMENT OF ORPHAN DRUG FOR RARE DISEASE

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ABOUT AUTHORS:
Kamshette Sharada*, Poul Bhagwat, Ghodke Amol
Department of Quality Assurance,
Maharashtra College of Pharmacy,
Nilanga, Maharashtra, India.
*sharadakamshette@gmail.com

ABSTRACT
Simply receiving a diagnosis of a rare disease often becomes a frustrating quest, since many doctors may have never before heard of or seen the disease. This is, however, a time of great progress and hope. Biopharmaceutical research is entering an exciting new era with a growing understanding of the human genome. Scientific advances have given researchers new tools to explore rare diseases, which are often more complex than common diseases.
“Who else has this rare disease? How many of us are there? What can I expect now? What is known or not known about this disease?” These are among the questions that patients and family members ask as they become, out of necessity, advocates for themselves or others.


EVALUATION OF THE SYNERGIC ANTIPROLIFERATIVE AND CYTOSTATIC EFFECTS OF ANANAS COMOSUS, CITRALLUS LANATUS AND CITRUS SINENSIS JUICE

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ABOUT AUTHORS:
Enegide Chinedu1*, Arome David1, Solomon F. Ameh1, Ugochi Ilomuanya2
1Department of Science Laboratory Technology (Physiology & Pharmacology Technology), University of Jos, Jos, Nigeria
2Department of Food Science & Technology, University of Nigeria, Nsukka Nigeria
chinex.snow@gmail.com

ABSTRACT
Background:
The World Health Organization (WHO) has named cancer as one of the most significant cause of death presently, with about 6 million reported deaths in 1996, 11.4 million deaths in 2004, 7.6 million deaths in 2008 and 8.2 million deaths in 2012. However, present postulations reveal that there might be an escalation of cancer mortality to about 15 million by 2030, if the progression of the ailment is not checked. Aim: The aim of this study is to evaluate the synergic antiproliferative and cytostatic effects of these fruit (Ananas comosus, Citrullus lanatus and Citrus sinensis) juices. Materials and Method: The study was performed on rapidly proliferating seeds of Sorghum bicolor and the resulting mean radicle lengths (mm) were taken after 24, 48 and 72 hours. Result: The seeds treated with methotrexate showed a significant (P<0.05) inhibition of radicle length growth throughout the experiment, compared with the control seeds radicle. The rate of inhibition after 72 hours was 85.39%. The juice doses of 20 and 40% showed a significant (P<0.05) inhibition of seeds radicle length throughout the 72 hours of study. The inhibition rate was however higher after 72 hours with percentage inhibition of 87.19% at 20% juice concentration and 99.50% at 40% concentration. However, juice concentrations of 60 and 80% gave a cytostatic effect (i.e no radicle growth) throughout the study. Conclusion: The study has shown that A. comosus, C. lanatus and C. sinensis mixed juice has a potential for eliciting antiproliferative and cytostatic effects on rapidly proliferating cells.


ORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM- A REVIEW

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ABOUT AUTHORS:
Manisha Gahlyan*, Saroj Jain
Hindu college of pharmacy
Near Panchayat Bhawan, Gohana Road, Sonepat, Haryana
manishagahlyan@gmail.com

ABSTRACT:
Oral route has been the most popular and successfully route for controlled delivery of drugs because of the flexibility in the designing of dosage form than other routes. The immidiate release conventional dosage form lack in the efficiency of controlling the proper plasma drug concentration. This factor as well as factors such as repetitive dosing ++and unpredictable absorption leads to the concept of oral controlled release drug delivery systems. A desirable characteristic of controlled release delivery system is that the duration of drug action should be dictated by the design property of drug molecules. There are different mechanistic aspects for design of oral controlled release drug delivery systems such as matrix, reservoir, osmotic pressure, ion exchange resins, altered density etc. This article contains brief review on currently existing oral controlled system and various formulation approaches for the controlled release system.


MINI-STROKE (TIA): A REVIEW

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ABOUT AUTHORS:
V. Sravanthi*1, Mayure vijay kumar1, Donthineni Kalyan2, G.J.Finny1, C.P.Meher1
1Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
TIA stands for transcient ischemic attack, is a temporary blockage of blood flow in the brain that causes stroke symptoms. A transient ischemic attack is often called a mini-stroke. It is considered a warning sign that a more serious stoke will happen in the future. They may include weakness on one side of the body, dizziness, blurred vision, confusion, and speech problems. A TIA is a medical emergency. Following the below words cover about transient ischemic attacks (TIA), medication, prevention, diagnosing etc.


A REVIEW ON STABILITY GUIDELINES BY ICH AND USFDA GUIDELINES FOR NEW FORMULATION AND DOSAGE FORM

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ABOUT AUTHORS:
Anilkumar S. Chinchole1*, B.N.Poul2, C.V. Panchal1, D.V. Chavan1
1Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga, Latur, Maharashtra, India
2Principal of Maharashtra College of Pharmacy, Nilanga
Maharashtra College of Pharmacy, Nilanga, Latur, Maharashtra, India
*anilc14@gmail.com

ABSTRACT
Stability guidelines for new drug substance and new pharmaceutical formulations as per ICH and USP for the evaluation and consistency for new drug and pharmaceutical dosage form. The brief understanding of these guidelines can be easily recognized by this article. Stability testing Provide a evidence on how the quality of a drug substance or drug product varies with time under the influence of a variety of environmental factors such as temperature, humidity, and light. To establish a re-test period for the drug substance or a shelf life for the drug product and recommended storage conditions. Because physical, chemical or microbiological changes might impact the efficiency and security of the final product. To minimize the Adverse Effects Of Instability In Drug Products Loss of potency of drug such as Change in concentration of active drug, Alteration of bioavailability, Loss of content uniformity, Loss of pharmaceutical elegance and patient acceptability, Formation of toxic degradation products.


BIOLOGICAL PROPERTIES, PHYTOCHEMISTRY AND TRADITIONAL USES OF RUDRAVANTI (CRESSA CRETICA): A REVIEW

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ABOUT AUHTORS
Nishant Verma 1*, K.K. Jha1, Rajesh Sharma1, Sudhir Chaudhary2, Ajai Kr. Singh3, Arvind Kumar 4
1Department of Pharmaceutical Chemistry, T. M. College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India
2Department of Pharmaceutical Technology, MIET, Meerut, Uttar Pradesh, India
3Department of Pharmaceutics, Gandhi College of Pharmacy, Karnal, Haryana, India
4Department of Quality Assurance, Onco Therapies Limited (A Mylan Company), Bangalore, Karnataka, India.

* nishantvermamiet@gmail.com

ABSTRACT
Since long, the ayurvedic period, the herbal drugs were the sole source of medication for majority of population pertaining to the holistic approaches consisting of easier method of uses and better results. Despite vast continuous developments in the drug therapy, herbal sources are still of great importance and nearly 60% of the world’s population continuously using such drugs. These are not only used for primary healthcare in rural areas in developing countries, but also in developed countries as well where modern medicines are predominantly available. In spite of industrious and versatile unbroken advancements in ayurvedic medicines of the present therapeutic arena, still a huge number of herbal origins leading to a vast variety of flora remains unexplored that could be utilized in the treatments for several afflictions i.e. diabetes mellitus, hepatitis, inflammation, cirrhosis of lever, cancers etc. Hence the satisfactory and safer solution to these problems of the public health care requires tremendous attention of the researchers to explore out medicinally efficacious plants and isolate potent molecules from them. Evaluation of such molecules could generate broader spectrum of pharmacodynamic and pharmacokinetic parameters with least toxicity. Cressa cretica (Linn) belonging to family Convolvulaceae. It is commonly known as Rudravanti. Traditionally root and leaves of Cressa cretica are commonly used as expectorant and antibilious agent. It is a holophytic dwarf shrub used in folklore medicine. This article gives the updated information on its properties.


DNA MICROSATELLITES: A REVIEW

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About Authors:
Shikha Jain*, Ranjana Joshi, Kirti Jatwa, Avnish Sharma, S.C. Mahajan
Department of Pharmaceutics,
Mahakal Institite of Pharmaceutical Studies,
Behind Air strip, Datana, Dewas Road, Ujjain, M.P.
jain.shikhapharma@gmail.com

Abstract
Microsatellites consist of tandemly repeated sequence, no more than 6 bases long. They are scattered throughout most eukaryotic genomes. The major characteristic that makes microsatellites as useful and powerful genetic tool is the extensive length polymorphism that first of all reflects allelic variation in the number of the tandemly arranged perfect repeats. Microsatellite are generally considered as the most powerful genetic marker.
A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. Genetic marker that reveal polymorphisms at the DNA level are called molecular marker.
Molecular markers are called as DNA markers, which should be thought of as signs along the DNA trail that pinpoint the location of desirable genetic traits or indicate specific genetic differences.They are responsible for various neurological diseases and hence the same cause can now be utilized for the early detection of various diseases, such as, Schizophrenia, Bipolar Disorder and Congenital generalized Hypertrichosis . These agents are widely used for forensic identification and relatedness testing, and are predominant genetic markers in this area of application.


A REVIEW OF NATEGLINIDE IN THE MANAGEMENT OF TYPE 2 DIABETES

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ABOUT AUTHORS:
Mistry Ripal*, Haresh T. Mulani
Department of Pharmaceutics
Indubhai Patel College of Pharmacy and Research Centre,
Dharmaj, Gujarat
*rx.ripalmistry@gmail.com

ABSTRACT:
Diabetes mellitus, or simply diabetes, is a chronic disease that occurs when the pancreas is no longer able to make insulin, or when the body cannot make good use of the insulin it produces. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The success of oral hypoglycemic drug therapy is usually based on are storation of normal blood glucose levels. Traditionally, the term oral hypoglycemic was used interchangeably with sulfonylureas, but more recently the development of several new drugs has broadened this designation to include all oral medications for diabetes. Nateglinide, a D-phenylalanine derivative, is a novel insulinotropic drug which has recently been launched as a therapeutic agent for Type II diabetes. Clinical studies have shown that nateglinide induces a rapid onset of insulin release synergistic with meal administration which effectively restores the early phase of insulin secretion. Since the loss of early insulin secretion is thought to play an important role in the development of glucose in tolerance the ability of nateglinide to promote early insulin release is potentially of considerable therapeutic benefit.