Articles

About Authors:
Masani Jigneshkumar Naranbhai
School Of Science
Biomedical Technology
Jiwaji University, Gwalior
jigneshmasani11@gmail.com

ABSTRACT
A supernumerary marker chromosome is an extra structurally abnormal chromosome of unknown origin. Various factors contribute to the difficulty of clarifying the phenotypicrisks of super numerary marker chromosomes (SMC), including differences inthe size, structure, and origin of marker chromosomes.

All marker chromosomes do not contribute the same risk of recurrence. Therefore characterization of the marker chromosomes is of utmost importance for Genetic Counseling. Different molecular techniques can be used to identify the chromosome material present in the markers. In the present retrospective data analysis of 15,000 karyotypes of all patients referred to the Center of Medical Genetics, Sir Ganga Ram Hospital from 1998 to 2012. For constitution chromosome abnormality detection, we found fifteen (0.01%) patients had presence of the SMC. Of these fifteen, eight markers had been characterized after FISH was introduced in the year 2004.  This contributed to personalized Genetic Counseling and help for future pregnancies.

About Authors:
Najneen S. Shaikh^1*, Mr. MAYURESH. K. RAUT^2
1Sinhgad Institute of Pharmaceutical Sciences (SIPS), Lonavala
²Asst. Professor Of Phamaceutical Chemistry
Sinhgad Technical Education Society,
Kusgaon (Bk), Lonavala- 410401
*naj.pharma.23@gmail.com

ABTRACT
Glycogen synthase   kinase 3 (GSK-3) is a serine/threonine protein kinase, that mediates the addition of phosphate molecules on certain serine and threonine amino acids in particular cellular substrates.
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with these diseases. GSK3 is a widely influential enzyme that is capable of phosphorylating, and thereby regulating, over forty known substrates. Four mechanisms regulating GSK3 (phosphorylation, protein complexes, localization, and substrate phosphorylation) combine to provide substrate-specific regulation of the actions of GSK3. Several intracellular signaling cascades converge on GSK3 to modulate its activity, and several neurotransmitter systems also regulate GSK3, including serotonergic, dopaminergic, cholinergic, and glutamatergic systems. Because of changes in these neurotransmitter systems and the actions of therapeutic drugs, GSK3 has been linked to the mood disorders, bipolar disorder and depression, and to schizophrenia.

About Authors:
Indraneel sinha*, Mr. Sanjay sahai, Mr. Sunil jajoo, Mr. Abhijeet bhatkar
Post graduate diploma in pharmaceutical management,
Indian institute of health management research,
jaipur
*indraneel.sinha.999@gmail.com

COMPANY PROFILE
Sun Pharmaceuticals was set up in 1983 and the company started off with only 5 products to cure psychiatric illness.  Sun Pharma is best known worldwide as the manufacture of specialty Active Pharmaceuticals Ingredients (API) and formulations.

However, the company is also concerned with chronic treatments such as cardiology, psychiatry, neurology, gastroenterology, diabetology and   respiratory ailments. Active Pharmaceuticals Ingredients (API) includes peptides, steroids, hormones, and anti?cancer drugs and their quality is internationally approved. Mr. Dilip S. Shanghvi is the Executive Chairman and Managing Director of Sun Pharma and Mr. Kamalesh H. Shah is the secretary.

About Authors:
Kapil Sharma^*1, Subhash Gupta ^2
1 Yaresun Pharmaceutical Pvt. Ltd.,India.
² Oasis test house ltd. Jaipur-302006, Rajasthan, India.
*pharma_kapil@rediffmail.com

ABSTRACT
A method for simultaneous estimation of Atorvastatin (ATVS) and Amlodipine (AMLD) in raw material and in combined tablet dosage form has been developed. The method employs the application of RP-HPLC. Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 245 nm and retention time of ATVS was 6.97 min and 3.96 min of AMLD.³  This method produced linear responses in the concentration range 20-140 µg/ml and 10-70 µg/ml for ATVS and AMLD respectively. The accuracy of the method was assessed by recovery studies and was found to be 100.54± 0.19 and 100.08±0.80 for ATVS and AMLD respectively.The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture of raw material and in market available tablet dosage form. Results of the analysis were validated statistically so that it can be used for routine analysis of ATVS and AMLD in combined tablet dosage form.^4-6

About Author:
Kapil Sharma
Yaresun Pharmaceutical Pvt. Ltd., India.
pharma_kapil@rediffmail.com

Introduction:
Arthritis is the name given for painful joint diseases. Arthritis one of the most common health problems in india. Arthritis also is the leading cause of disability. Rheumatoid arthritis (RA) is a chronicinflammatory condition of the connective tissues throughout the body, but especially around the joints. The main sign of RA is often stiff, painful, and swollen joints.  Areas of typical complaint include the hands, feet, wrists, ankles, and knees.  Depending on the severity of the condition, these areas may eventually become deformed. The exact cause of rheumatoid arthritis remains, largely, unknown.  It has been theorized that a number of genetic and environmental factors may contribute to the disease process, and may include genetics, poor nutrition, lifestyle, chronic stress in rheumatoid arthritis, the joint lining, or synovial membrane, becomes inflamed and the joints become stiff and swollen. The synovial membrane secretes a slippery fluid that covers the cartilage-covered joints and reduces the friction between adjacent joints.The chronic inflammation of rheumatoid arthritis eventually leads to destruction of the cartilage covering the ends of the joints and underlying bone.  In many cases this damage causes joint deformity.

About Authors:
ANUJ SINGH
VINAYAKA MISSION’S UNIVERSITY
Salem – 636308, Tamil Nadu
anuj.dra@gmail.com

ABSTRACT:-
Healthcare Regulatory Affair Professional with their experience and strong motivation to excel in the Regulatory field has an ability to motivate & give support and strengthen to teams members, involved in process of product registration. Professional has taught a self-starter with the proven ability to prioritize and manage projects in a busy, fast-paced, multitasking environment, along with their experience in establishing relationship with the decision makers & coordinator. The Pharmaceutical industries are among the most highly regulated industries in the country. As India is growing very rapidly in pharmaceutical sector, there is a need of regulatory affairs professionals to cater the current needs of industries for the global competition. Regulatory affairs professionals are the link between pharmaceutical industries and worldwide regulatory agencies. They are required to be well versed in the laws, regulations, guidelines and guidance of the regulatory agencies. There is a growing need to incorporate the current requirements of pharmaceutical industries in the standard curriculum of pharmacy colleges to prepare the students with the latest developments to serve the industries. The present article discusses the regulatory education and its need, learning resources, courses available, syllabus contents and job opportunities in regulatory affairs.

About Authors:
DHIRAJ YADAV
BABU BANARASI DAS UNIVERSITY,
LUCKNOW
dhirajyadav06@gmail.com

ABSTRACT
Miconazole is the antifungal drug, has been used in the treatment of fungal infection of skin and also in yeast infection. In order to decrease the skin rashes, skin irritation, and also for best effect on the skin, miconagol gels have been developed. This study was conducted to develop a gel formulation of miconazole using four types of gelling agents: carbopol, carboxymethylcellulose sodium (Na CMC) and sodium alginate. Effect of penetration enhancer (propylene glycol) on the release has been studied. The gels were evaluated for physical appearance, rheological behaviour, drug release and stability. The drug release from all gelling agents through a standard cellophane membrane was evaluated using Keshary-Chien diffusion cell. All batches of gels showed acceptable physical properties concerning colour, homogeneity, consistency, spreadability and pH value.
Among all the gel formulations, carbopol showed superior drug release than followed by Na CMC, and sodium alginate. Drug release decreased with increase in polymer concentration. Drug release was not linearly proportional with the concentration of penetration enhancer or co-solvents. Stability studies showed that the physical appearance, rheological properties, and drug release remained unchanged upon storage for two months at ambient condition.

About Authors:
Krishn Kumar Agrawal*, Kishan Singh, Bhupesh Chander Semwal
Institute of Pharmaceutical Research GLA University,
Mathura-281403 (U.P.) India.
*Krishn.agrawal@rediffmail.com

ABSTRACT:
Medicinal plants have been a major source of therapeutic agents since ancient times to cure human disease. Aloes species (family-Liliaceae) is a widely used herbaceous, shrubby, arborescent, perennial or xerophytic succulents medicinal plant cultivated throughout India and popular in various indigenous system of medicine like Ayurveda, Siddha, Unani and Tibb. Traditionally the juice of aloe is used as bitter, laxative, purgative and cathartic. They are also useful in jaundice, dyspepsia, piles, skin disease, abotificient, trophic ulcer, wounds healing and many more ailments. The present review is therefore, an effort to give a detailed survey of the literature on pharmacognosy, phytochemistry and pharmacological activities of the plant.