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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PROPYPHENAZONE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
Mehul Kakdiya*, Avinash Nagapara, Darshan Madiya, Shital Faldu
Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
*kakdiyamehul@gmail.com

Abstract
A simple, precise, accurate and reproducible spectrophotometric method has been developed for  simultaneous estimation of Paracetamol (PCM) and Propyphenazone (PP) by employing first order derivative zero crossing method in Methanol. The first order derivative absorption at 249 nm (zero cross point of Paracetamol) was used for quantification of Propyphenazone and 274 nm (zero cross point of Propyphenazone) for quantification of Paracetamol. The linearity was established over the concentration range of 1-12 µg/ml and 5-24 µg/ml for Paracetamol and Propyphenazone with correlation coefficient r2 0.999 and 0.996, respectively. The mean % recoveries were found to be in the range of 100.48-102.119% and 100.448-102.713 % for Paracetamol and Propyphenazone, respectively. The proposed method has been validated as per ICH guideline and successfully applied to the estimation of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form.


HISTORY OF CATIONIC VS ANIONIC: IN NASAL DRUG DELIVERY SYSTEM

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ABOOUT AUTHORS:
Manu Sharma1, Shikha Chaudhary1, Dharmendra Kumar2*
1 R.V.Northland institute, greater Noida, Dadri, UP, India
2
Brahmanand Group of Institution, 195, Khurja G.T Road, Buldshahar Uttar Pradesh, India.
*rvnimiet@gmail.com

ABSTRACT
Chitosan as cationic and pectin as anionic are natural polysaccharides which show great potential in nasal drug delivery system. Chitosan’s are strongly poly-cationic. They are derivatives of poly-N-acetyl-D-glucosamine. Chitosan’s have positive charge that is responsible for mucoadhesion and play an important role in nasal drug delivery system Pectin’s have several structural elements: Homogalactouronan are smooth and Rhamnogalactouronan are hairy which play a very important role.By methyl esterifications, pectin’s are divided in two types: High methoxypectin’s and low methoxypectin’s. Low methoxypectin’s are very important in the formulation of nasal gel, because they have properties to form the gel with calcium ion (Ca2+).


PHYTOCHEMICAL SCREENING & EVALUATION OF ANTIMICROBIAL ACTIVITY OF GLYCYRRHIZA GLABRA LINN

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ABOUT AUTHORS:
Pankaj Kushwah1*, D.K. Vir2, Nandu Kayande2, Ravina Patidar2
1Department of Pharmacognosy, Nimar Institute of Pharmacy, Dhar, MP
2Department of Pharmacology
Nimar Institute of Pharmacy, Dhamnod, Opp.ITI, Maheshwar Road Dhamnod, Dhar. M.P.
pankajnipd@gmail.com

ABSTRACT
The present study was undertaken to explore the phytochemical screening & antimicrobial activity of stems of Glycyrrhiza Glabra L. (Leguminaceae). Glycyrrhiza Glabra L. were screened for their antimicrobial activity by agar well diffusion method, standard screening method & disc diffusion method. In the phytochemical screening showed presence of secondary metabolites, flavonides, glycosides & terpenoids. It is also showed potent against almost all the test organism.

Study indicate that Glycyrrhiza Glabra has antibacterial, antioxidant, antimalerial, antispasmodic, anti-inflammatory and anti-hyper glycemic properties. Various other effects like antiulcer, antiviral, antihapatotoxic, antifungal and herpes simplex have also been studies. One of the most commonly reported side effects with licorice supplementation is elevated blood pressure.


MUSCULAR DYSTROPHY: A REVIEW

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About Authors:
Naga Manjusha. Somavarapu*, Ramya krishna. Barma
Department Of Pharmacology, Shri Vishnu College Of Pharmacy,
Bhimavaram, W. G. Dist., A. P.
snmanjusha8@gmail.com

Abstract:
Muscular dystrophy is one of the rare diseases that cause progressive weakness and degeneration of skeletal muscles used during voluntary movement. There are many different types of muscular dystrophy based on the age of onset, severity and pattern of inheritance, of which duchenne and becker muscular dystrophies being more prevalent. The absence or abnormality of dystrophin, a protein which forms a complex with extracellular matrix to provide mechanical reinforcement to the structure of the sarcolemma and thereby protecting the membrane from the stress or tearing during contraction is the main cause of muscular dystrophy. Muscular dystrophy can be diagnosed by blood & urine tests, muscle biopsies, DNA (genetic) testing, and diagnostic imaging and neurophysiology studies. Treatment includes various therapies such as respiratory therapy, physical therapy, speech therapy, occupational therapy, corrective surgery, drug therapy, and gene therapy.


Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PARACETAMOL AND PROPYPHENAZONE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
1Mehul Kakdiya*, 2Viral Kakdiya, 1Darshan Madiya
1Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College, Rajkot
2Pacific college of pharmacy, Udaipur, Rajasthan
*kakdiyamehul@gmail.com

Abstract
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of Paracetamol and Propyphenazone in their combined pharmaceutical dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an isoabsorptive point and other being the λ-max of one of the two components.  Paracetamol and Propyphenazone show an isoabsorptive point at 264 nm in methanol.The second wavelength used is 249 nm, which is the λ-max of Paracetamol in methanol. The linearity was obtained in the concentration range of 1-12 μg/ml for Paracetamol and 5-24 μg/ml for Propyphenazone. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Paracetamol. The method was successfully applied to pharmaceutical dosage form because of no interference. The results of analysis have been validated by recovery studies.


ENDANGERED AQUATIC MEDICINAL PLANTS OF KERALA

ABOUT AUTHOR:
Uma Nath.U
Department Of Pharmaceutical Analysis,
Daleview College Of Pharmacy And Research Centre,
Punalal, Trivandrum, Kerala
umaanalysis@yahoo.co.in

ABSTRACT
The aquatic plants in kerala are of greatest medicinal importance as that of the herbs. Some of these plants where used for serious disease treatment like cancer and genetic disorders. The folk medicines indicate the use of certain aquatic plants even for inducing polyploidy. The aquatic plants usage in medicines is now nearly ignored and they are under extinction. This paper deals with the description of some of these medicinal plants. It mainly concentrates on aquatic plants present in the ponds of kerala.


POLYPHARMACY IN GERIATRICS

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About Authors:
T. Vishnuvaravidyadhar*, M. Sushma, R. Mohanraj, M. Babu  
Department of Pharmacy Practice,
Raghavendra Institute of Pharmaceutical Education & Research, RIPER
K R Palli Cross, Near S.K University,
Anantapuramu District, Andhra Pradesh, INDIA

*vishnuvaravidyadhar@gmail.com

Abstract:
Geriatrics is more prone to higher risks of chronic illness and are using multiple medications in order to lead healthy life. Polypharmacy increases the risk of adverse drug events, as a result changes takes place in physiological, social, physical and functional decline in the body. These rapid physiological changes make elderly patients unable to cope with body stresses. Drug toxicity, side effects and adverse drug reactions appear more frequently and are more life-threatening in elderly patients. Tetracyclins, streptomycin, reserpine, and all barbiturates are to be contraindicated in geriatrics in order to prevent further complications. Polypharmacy is the simultaneous taking of many medications, has been well documented and is a topic of much concern for those looking to improve the quality of care for the elderly. Elderly patients often develop complicated conditions and multi-factorial health states that require extensive pharmacotherapy, sometimes surgery leaving the population at risk for exposure to drug-drug interactions, drug-food interactions and other adverse events. Previously literature states that rate of adverse events are directly proportional to number of drugs taken by the patient. To manage all these complications and to avoid polypharmacy Dose regimen should be simple and drugs should be given in combinations to improve patient compliance.


NEW SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION OF LUMEFANTRINE

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ABOUT AUTHORS:
*1Baokar Shrikrishna, 1Annadate Amol, 2Undare Santosh
1Department of Pharmaceutical Chemistry, SVPM’s College of Pharmacy, Malegaon (Bk II), Tal-Baramati, Dist- Pune, Maharashtra, India
2P.G. Department of chemistry, Balbhim arts, science and commerce college, Beed
krishnabaokar@gmail.com

ABSTRACT
A Simple, sensitive, specific, spectrophotometric method has been developed for the detection of Lumefantrine in pure and Pharmaceutical formulations. The optimum condition for the analysis of the drug was established. Lumefantrine shows maximum absorption at 228 nm and obeyed beers law in the concentration range 10 to 50 µg/ml.

The correlation coefficient was found to be 0.999 and slope of line was found to be 0.0635. The percent S.D. for intra assay precision of the method was found to be 1.85% whereas Inter assay precision was found to be 0.44%. The sample solution was stable up to 24 hours. The assay results were found to be in good agreement with label claim.

The proposed method was simple sensitive, precise, quick and useful for routine quality control.


Q-ABSORBANCE RATIO SPECTROPHOTOMETRIC METHOD FOR THE SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND CANDESARTAN CILEXETIL IN SYNTHETIC MIXTURE

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ABOUT AUTHORS:
Kotecha B*, Pambhar M, Zala G, Faldu S
Department of Quality assurance, Smt. R.D. Gardi B.Pharmacy College,
Nyara, Rajkot-360 110, Gujarat, India
kotecha_bijal29@yahoo.com

ABSTRACTS:
The present manuscript describe simple, sensitive, rapid, accurate, precise and economical q-absorbance method for the simultaneous determination of Amlodipine besylate and Candesartan cilexetil in synthetic mixture. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one which is an Isoabsorptive point at 242 nm in Methanol. The second wavelength is used 255 nm, which is λmax of Candesartan cilexetil in Methanol. The linearity was obtained in the concentration range of 5-25 μg/mlof both drugs. The concentration of drugs was determined by using ratio of absorbance at isoabsorptive point and at the λ-max of Candesartan cilexetil. The method was successfully applied to pharmaceutical dosage form because of no interference. The result of analysis has been validated by recovery studies.


A REVIEW ON GAS GANGRENE AND ITS MANAGEMENT

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About Authors:
M. Sushma*, T. V. V. Vidyadhar, R. Mohanraj, M. Babu
Department of Pharmacy Practice,
Raghavendra Institute of Pharmaceutical Education & Research, RIPER,
K R Palli Cross, Near S.K University, Anantapur District, Andhra Pradesh, 515721.
*sushma.banthi@gmail.com, vishnuvaravidyadhar@gmail.com

Abstract:
Gas gangrene is described as an infection of muscle tissue by toxin-producing clostridia. Gas gangrene is also known as “Clostridial myonecrosis”, gained recognition for its wartime incidence, during which only a paucity of civilian cases occurred during wars. Blood is major component in which its absences favour the development of gas gangrene. Such conditions were seen in the cases like atherosclerosis, diabetes, peripheral arterial disease. Depending on this blood supply and attack of infection the gas gangrene can be classified into Dry gangrene and Wet gangrene. This gas gangrene presents clinically with Dry and Cold skin with Pain and Swelling associated with Blisters. There are a typical causes and pathogenesis involving different type of toxins for the formation of gas gangrene. The treatment is approached by using a type ofMaggot therapy, Antibiotics, Oxygen therapy. Surgery also preferred in the treatment.