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ABSORPTION CORRECTION SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TORSEMIDE AND AMILORIDE HYDROCHLORIDE IN THEIR COMBINED DOSAGE FORM

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ABOUT AUTHORS:
Dilip G. Maheshwari, Rujuta D. Patel*
Department of Quality Assurance,
L.J. Institute of Pharmacy, Sarkhej, Ahemdabad, Gujarat, India
*Rujutapatel09@gmail.com

ABSTRACT:
A new sensitive, simple, rapid and precise spectrophotometric method has been developed for simultaneous estimation of Torsemide and Amiloride HCl in pharmaceutical dosage form. This method was based on UV spectrophotometric determination of two drugs, using absorbance correction method. It involves measurement of absorbances at two wavelengths 288nm(λmax of Torsemide (TOR)) and 361nm (λmax of Amiloride HCl (AMI)) in methanol for the simultaneous quantitative determination of Torsemide and Amiloride HCl in the binary mixture without previous separation. The linearity was observed in the concentration range of 5 -25 μg/ml for Torsemide and 5-25 μg/ml for Amiloride HCl. The accuracy and precision of the method was determined and validated statically. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of Torsemide and Amiloride HCl in combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.


DIABETES AND ITS COMPLICATIONS AND SGLT-2 INHIBITORS: A NOVEL THERAPY FOR TYPE 2 DIABETES MELLITUS

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About Authors:
Shivkant M. Kide*, Rahul M. Kide, Lokesh T. Thakare, Komal V. Ambulkar
Department of Pharmacology,
Institute of Pharmaceutical Education and Research,
Borgaon (Meghe), Wardha-442 001,(M.H.), India.
shivpharma08@gmail.com

ABSTRACT:
The incidence of type 2 diabetes mellitus is increasing worldwide. The pharmacotherapy for type 2 diabetes until the last decade only consisted of biguanides, sulphonylureas, and insulin. The existing therapeutic classes of antidiabetic drugs are not adequately effective in maintaining long-term glycemic control in most patients, even when used in combination. One emerging novel therapeutic class of antidiabetic drugs is sodium glucose cotransporter 2 (SGLT2) inhibitors. SGLT2 accounts for 90% of the glucose reabsorption in the kidney. The SGLT2 inhibitors increase urinary excretion of glucose and lower plasma glucose levels in an insulin-independent manner. Forxiga (Dapagliflozin) the most prominent molecule in this class is currently approved by USFDA. Other members of this class (eg, sergliflozin, remogliflozin) are also effective. This class of novel agents can effectively control blood sugar level without producing weight gain or hypoglycemia.


FORCED DEGRADATION AND STABILITY TESTING: STRATEGIES AND ANALYTICAL PERSPECTIVES

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ABOUT AUTHORS:
U. A. Deokate, A. M. Gorde*
Dept. Of Pharmaceutical Chemistry,
Government College of Pharmacy, Hotel Vedant Road, Osmanpura,
Aurangabad, Maharashtra, India 431005
gordeanjali@gmail.com

ABSTRACT:
This review discusses the regulatory aspects of forced degradation and methodology aspects for degradant investigations. It also focuses on the prediction of degradation products and pathways and development of stability indicating assay method. While reviewing the analytical perspectives various conventional and hyphenated techniques for degradant separation and characterization are described in detail.


PHARMACOLOGICAL SCREENING OF ETHANOLIC EXTRACTS OF EMBLICA OFFICINALIS GEARTH PLANT ON ANIMALS

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ABOUT AUTHORS:
Nandu Kayande1*, Pankaj Kushwah2, D. K. Vir1
1Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Opp.ITI, Maheshwar Road Dhamnod, Dhar. M.P.454552
nandu_kayande@rediffmail.com

ABSTRACT
The main objective of the present work is to find out good pharmacological activities in herbal source with their preliminary phytochemical study, and also it is aimed to investigate of ethanol, and aqueous extracts of dried stem of plant Emblica Officinalis Gearthagainst with Anti-inflammatory and in rats, Analgesic activity in mice and antioxidant in invitro methods. Normally herbal products are free from side effects/adverse effects and they are low cost medicines,which will be beneficial for human being. The main objective of this work is to find active constituents which are potent Anti-oxidant, Anti-inflammatory, analgesic having no or minimum side effects from indigenous plants for the therapeutic management.


DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF BROMHEXINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM

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About Authors:
Dharmesh R. Mevada*, Krutika Bhalodiya, Brijesh Maniar, Ketan Dadhania, Shital Faldu
Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College,
Rajkot, Gujarat, India
*dharmeshmevada89@gmail.com

Abstract
UV Spectrophotometric method has been developed for simultaneous estimation of Bromhexine HCl (BHX) and Phenylephrine HCl (PLE) in bulk drug and in their combined Pharmaceutical dosage form by first order derivative. This method utilizes methanol as a common solvent and λmax of BHX and PLE selected for analysis was found to be at 241 nm (at ZCP of PLE) and 233 nm (at ZCP of BHX) respectively. Linearity was observed in the concentration range of 5-30 μg/ml for BHX (r2 = 0.999) and 10-60 μg/ml for PLE  (r2 = 0.998). The accuracy and precision were determined and found to comply with ICH guidelines. This method showes good reproducibility and recovery with % RSD in the desired range. Developed method was applied for marketed formulation. The results were found to be within  acceptance criteria according to ICH guideline. This method was simple, rapid, accurate, Precise and sensitive.


FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF AMBROXOL HYDROCHLORIDE

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ABOUT AUTHORS:
Samatha.M*, Deepthi.P, N. Srinivas
Department of pharmaceutics,
Malla Reddy Institute of Pharmaceutical Sciences, Secunderabad
samathamapashetti@gmail.com

ABSTRACT
In the present study, an attempt was made to formulate the oral sustained release matrix tablets of AmbroxolHCl in order to improve the efficacy, reduce the frequency of administration, and better patient compliance. Ambroxol Hydrochloride is a potent mucolytic agent which induces bronchial secretions used in the treatment of respiratory disorders. FTIR analysis confirmed the absence ofany drug polymer interaction. Sustained release tablets of Ambroxol Hydrochloride were formulated employing hydrophilic polymers HPMC K4M and HPMC K100M. The powder blend was evaluated for micromeritic properties. The sustained release tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weightvariation test, hardness, friability, and drug content. The in vitro drug release characteristics were studied in simulated gastric fluid (2 hours) andintestinal fluid for a period of 10 hours using USP type II dissolution apparatus (total 12hours). The results of dissolution studies indicated that formulation F11 is the most successful of the study with satisfactory drug release. At the end of 12 hrs, the drug release was found to be 96.1%.


USE OF PYRETHRIN/ PYRETHRUM AND ITS EFFECT ON ENVIRONMENT AND HUMAN: A REVIEW

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About Authors:
Vishal Soni*, Amruta Anjikar

CSIR-National Environmental Engineering Research Institute (NEERI),
Nagpur, Maharashtra
vishalsoni8912@yahoo.com

Abstract:
Pyrethrins and pyrethrum are the most frequently used home and garden insecticides in the India. They are often used in indoor sprays, pet shampoos, and aerosol bombs to kill flying and jumping insects. Pyrethrins are a common cause of insecticide poisonings. According to Ministry of Environment and Forest survey of poison control centers, they cause more insecticide poisoning incidents than any other class of insecticides except the organophosphates. Symptoms include headaches, dizziness, and difficulty breathing. Pyrethrins can trigger life-threatening allergic responses including heart failure and severe asthma. In laboratory animals exposed through eating, by injection, or through breathing, pyrethrins have caused anemia. Experiments with dairy cows suggest that nursing mothers exposed to pyrethrins can pass them on to their children. Pyrethrins disrupt the normal functioning of sex hormones. They inhibit binding of sex hormones to human genital skin and proteins in human blood. Pyrethrins are classified as “likely to be human carcinogens” by Environmental Protection Agency (EPA) because they cause thyroid tumors in laboratory tests. Farmers who use pyrethrins have an increased risk of developing leukemia. Pyrethrins are extremely toxic to bees, fish, and other aquatic animals. Following indoor treatments, pyrethrins have persisted up to 2 1/2 months in carpet dust.


DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF OLMESARTAN MEDOXOMIL AND CILNIDIPINE BY SIMULTANEOUS EQUATION METHOD

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About Authors:
Nehal C. Ghelani*, Krutika Bhalodiya, Ketan Dadhania, Shital Faldu
Department of Quality Assurance
Smt. R. D. Gardi B. Pharmacy College, Rajkot, Gujarat, India
*nehalghelani10@gmail.com

Abstract
UV Spectrophotometric method has been developed for simultaneous estimation of Olmesartan Medoxomil (OLME) and Cilnidipine (CILNI) in bulk drug and in laboratory mixture. This method utilizes methanol as a solvent and λmax of Olmesartan Medoxomil and Cilnidipine selected for analysis was found to be 241 nm and 253 nm respectively. Linearity was observed in the Olmesartan Medoxomil concentration range of 4-20μg/ml and Cilnidipine concentration range 2 -10 ug/ml (r2 = 0.998 and r2 0.999) of both drugs. The accuracy and precision were determined and found to comply with ICH guidelines. This method showed good reproducibility and recovery with % RSD in the desired range. The proposed methods can be successfully applied for the routine analysis of both the drugs. This method was simple, rapid, accurate, and sensitive.


EVALUATION OF DIURETIC ACTIVITY OF GLYCYRRHIZA GLABRA LINN IN EXPERIMENTAL ANIMALS

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ABOUT AUTHORS:
Nandu Kayande1*, Pankaj Kushwah2
1HOD Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Opp.ITI, Maheshwar Road Dhamnod, Dhar. M.P.454552
nandu_kayande@rediffmail.com

ABSTRACT
The purpose of the present study was to evaluate the diuretic activity of glycyrrhiza glabra linn (Mulethi) in experimental animals by following the standard procedure. Randomly selected animals were divided into three groups of six animals each. The root of glycyrrhiza glabra linn was administered orally in the form of Kwatha at a dose of 6.2 ml/kg and 12.3 ml/kg. Parameters like volume of urine, pH of urine and urinary electrolyte concentrations like sodium, potassium and chloride were studied. glycyrrhiza glabra linn Kwatha increased the urine output in a dose-dependent manner. However, it did not affect the urinary electrolyte concentrations. From the present study, it can be concluded that the root of glycyrrhiza glabra linn has diuretic property.


EVALUATION OF ANTIHELMINTIC ACTIVITY OF ROOT OF BUTEA MONOSPERMA

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ABOUT AUTHORS:
Pankaj Kushwah1*, Kayande N.2
Department of Pharmacognosy,
Nimar Institute of Pharmacy, Dhar, MP
pankajnipd@gmail.com

ABSTRACT
The aim of present study was to evaluate antihelmintic potential of crude extract of root of Butea monospermous using Pheretima posthuma as test worm. Butea monosperma is distributed all over India and has been used by triable as well a local people widely. Popularly known as 'dhak' or 'palas', commonly known as ‘Flame of forest’. It has been found to have antimicrobial, wound healing, antifungal, antidiarrhoeal, hypoglycemic, hepatoprotective, antioxidant, anti-convulsive, antistress, anti diabetic, anti-inflammatory activity. It also used in treatment of goiter, spermatorrhoea and antidote for snake bite. In the present work the aqueous and alcoholic extracts of flowers of Butea monosperma were evaluated for its antihelmintic activity against adult earthworms (Pheretima posthuma).