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NONINVASIVE AMBULATORY BLOOD PRESSURE MONITORING AFTER ADMINISTRATION OF ACE-INHIBITOR/CCB AND THEIR COMBINATION
S.M Abdullah1*, M Tandon1, N Saha2, K K Pillai3
1M.Pharm, Department of Clinical Pharmacology Unit, Ranbaxy Laboratories Ltd, India.
2Department of Medical Affairs & Clinical Research, Ranbaxy Laboratories Ltd, India.
3Ph.D, Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard, India.
The principle for the treatment of hypertension as per JNC-7 guideline is ‘treat to blood pressure (BP) <140/90 mmHg’ but in common clinical practice it is often difficult to lower the BP below 140/90 mmHg with monotherapy. While majority of patients requires two or more drugs to achieve target BP, this finally calls for comparative clinical evaluation of antihypertensive drugs as co-administration verses monotherapy.
METHOD: This study was randomized, single-blind, double-dummy, three-treatment, crossover study includednewly diagnosed treatment naive essential hypertensive patients; aged 20-45 years with sitting office BP ranged 140-159/94-104 mmHg. After 4 weeks of regular measurements of BP, all subjects received each treatment in randomized order for 1 week: imidapril 5 mg and placebo (I/P), lercanidipine 10 mg and placebo (L/P) or imidapril 5 mg and lercanidipine 10 mg (I/L). Prior to dosing and at the end of each treatment period, 24-hours ambulatory blood pressure monitoring (ABPM) was performed. Recorded data was analyzed for the evaluation of pharmacodynamic potential of each treatment.Beside this time-effect profile was also evaluated in terms of trough-to-peak (T/P) ratio.
SRF, Departmnet of Pharmacology Division,
NRI-Panchakarma, Cheruthuruthy Post, Thrissur, Kerala
Multiple sclerosis(MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate, resulting in a wide range of signs and symptoms, including physical, mental and sometimes psychiatric problems. Multiple sclerosis is an autoimmune demyelinating disease of the central nervous system characterized by clinical attacks (relapses) correlated with lesions separated in time and space. MS is a severe inflammatory disease in which the myelin (insulator for electrical signalling in NS) breakdown and causes severe deficits in brain and nerve function. Much like rubber insulation on an electrical cord, myelin surrounds long projections from the body of neurron and allows signal to travel down the cell with sreed and efficacy Therefore patients suffers deficits in balance, coordination, moments as well sensory disturbances from the loss of this neuronal insulation. MS is one of the most common neurological causes of long term disability, the myelin producing oligodendrocytes of the CNS are the target of recurrent cell mediated autoimmune attack. MS is a episodic & progressive disease occurs in early to 35 years & then declining. MS occurs with male:female ratio of 2:1 The incidence is higher in temperature climate and in northen europeans.
Department of Pharmacy
Bengal School Of Technology, Hooghly, India
Plant materials have been used as medicine for a wide varity of human ailments due to increase cost of treatments, side effects of several allopathic drug and development of resistance to currently used drug for infectious disease. Cornsilk (Zea mays) is an herbal remedy made from stigmas, the yellowish thread-like strands found inside the husks of corn. Cornsilk is used to treat urinary tract infections and kidney stones in adults. Cornsilk also served as a remedy for heart trouble, jaundice, malaria, and obesity.
Ms. Kanika Soni, Ms. Pooja Dhiman*, Mr. Sandeep Singh
Chitkara University, Kalujhanda, Atal Shiksha Kunj,
Barotiwala, Solan [H.P], INDIA
Alzheimer's disease, the commonest cause of dementia in older people which causes immense distress to patients, their caregivers and families. The aetiology of Alzheimer's disease remains unknown, and no treatments reverse or stabilise the disease. Current management focuses on establishing an accurate clinical diagnosis, ensuring appropriate services are provided, supporting caregivers and treating associated non-cognitive problems because Alzheimer’s disease is the main cause of dementia. Dementia affects memory, thinking, language, judgment, behaviour, and a person’s ability to perform normal daily activities. Dementia is a word that describes symptoms of the gradual deterioration of mental functioning that cannot be explained by normal aging. Dementia occurs primarily in people who are over the age of 65, or in those with an injury or disease that affects brain function. While dementia is most commonly seen in the elderly, it is not a normal consequence of the aging process.
Narinderpal Kaur*, Annapurna Negi, Jyotsna
School of Pharmacy and emerging Sciences
Baddi University of Emerging sciences and Technology
Baddi, Himachal Pradesh
In recent years the synthesis of benzimidazole and its derivatives has attracted the attention of many organic chemists because of the compounds' interesting biological activity and the crucial importance of the benzimidazole unit in the function of these biologically important molecules. Benzimidazole and its derivatives play an important role in medical field with large number of Pharmacological activities such as antimicrobial, antiviral, antidiabetic and anticancer activity. This review is summarized to know about the chemistry of different derivatives of benzimidazoles along with their biological actions such as antioxidant, antimicrobial, anthelmintic, analgesic, antiprotozoal, antiulcer, antiviral, anticancer, antihypertensive, antineoplastic, antiinflammatory, antifungal and anticonvulsant activity.
ANTI-HISTAMINIC AND ANTI-SPASMODIC POTENTIAL OF ETHANOLIC EXTRACT OF TEPHROSIA PURPUREA (Linn.) PERS. AERIAL PARTS
Paresh Lallubhai Gajera*, Dalal Mittal V.
Department of Pharmacology, ROFEL,
Shri G. M. Bilakhia College of Pharmacy,
The aim of present study was to evaluate anti-histaminic and anti-spasmodic potential of ethanolic extract of aerial parts of Tephrosia purpurea (Linn.) against experimental animal models. In this study ethanolic extract of aerial parts of Tephrosia purpurea (L.) was prepared and anti-histaminic and anti-spasmodic activity evaluated on isolated goat tracheal chain and rat ileum preparation by dose response curve of histamine and acetylcholine in absence and in presence of ethanolic extract was plotted respectively. The results of present study revealed that EETP inhibits moderately significant (*p <0.05) percentage contraction at 50µg/ml while EETP inhibits significantly (**p<0.01) percentage contraction at 100µg/ml induced by histamine (10µg/ml) and acetylcholine (1µg/ml) in isolated goat tracheal chain and rat ileum preparation respectively. To, concluded, EETP possesses dose dependent antihistaminic and antispasmodic potential. However, future studies are required to focus on the molecular mechanism of responsible phytochemical constituents and establish exact mode of action involved in it.
Department of Pharmacology, Sunder Deep Pharmacy College,
NH-24 Dasna, Sunder Deep Nagar Ghaziabad,
Dyslexia is a neurological condition manifesting in children, who typically are average in intelligence, struggling academically. This tends to be confounding for parents who, based on their child's aptitude and general abilities in regard to problem solving, and should be able to read without too much difficulty but, nonetheless, they tend to struggle. Unfortunately, sometimes these children are labeled as "lazy" when, in fact, they tend to be working more diligently than other children to "keep up." Here we are having a brief about cause, symptoms, classification, positive aspects and management strategy to cope up with the children bearing this disorder.
Tripti Verma*, Chandra Shekhar Sharma, HemendraPratap Singh
Bhupal Nobles’ College of Pharmacy,
Udaipur, Rajasthan, India
Semicarbazones are compounds which are synthesized by a condensation reaction between a ketone or aldehyde and semicarbazide. Semicarbazone have biological activity against many of the most common species of bacteria. The biological properties of semicarbazonesare often related to metal ion coordination. The literature survey revealed that semicarbazones had been emerged as a compound with broad range of activities including anti-fungal, anti-bacterial, anticonvulsant, anticancer, antimicrobial activity and anti-inflammatory activity. Semicarbazone also used as ligand as the cytotoxic agent, spectrophotometric agents as well for the analysis of metal ions and in qualitative organic analysis of carbonyl compounds. In the present study we have focused on the Pharmacological evaluation of semicarbazone analogues. As per activity there are different Pharmacological evaluation methods of synthesized compound.
Charu Pundir1, Prof.Veermaram2, Maroof Ali3, Abhishek Joshi4
1B.Pharm, S.B.S.P.G.I, Dehradun, Presently studying M.Pharm. Pharmacology & toxicology at KLE University’s college of pharmacy, Belgaum, Karnataka
2,H.O.D, Dept. of Pharmaceutical Sciences, S.B.S.P.G.I, Dehradun
3B.Pharm, S.B.S.P.G.I, Dehradun
4M.Pharm, Pharmacology, Kumaon University
Neuro degenerative disease is the umbrella term for the gradual loss of brain parts, including death of neurons. This may lead to Parkinson- a gait disorder, Alzheimer, which is a common form of dementia and occurs with progressive increase in age. Genetic mutations, Protein misfolding, Oxidative stress, Excitotoxicity, Infectious Organism are the basic cause behind neuro degeneration. This can be estimated through Verticulography, CAT SCAN, MRI, Pneumoencephalography and Cerebral angiography. AD is the accumulation of β- amyloid plaques and formation of neurofibrillary tangles related to hyperphosphorylation of tau proteins. Treatment therapy includes medications, surgery, ayurveda, physiotherapy, yoga and stem cell therapy.
VISUAL INSPECTION WITH ACETIC ACID FOR CERVICAL CANCER SCREENING- AN EFFECTIVE STRATEGY IN LOW-RESOURCE SETTINGS
Dr. Balram Soni*
Psychiatric Centre, S.M.S. Medical College Jaipur, Rajasthan
A simple screening technique using an inexpensive agent dramatically reduced deaths related to cervical cancer in a population of Indian women. Visual inspection with acetic acid or vinegar (VIA), conducted by non medical personnel trained to deliver basic healthcare, cut the death rate by 31%. This strategy is effective and can be implemented on a broad scale in low-income countries. "There was almost no over diagnosis, it doesn't require a laboratory, and it can be widely implemented in the lowest-resource settings, such as India," If implemented nationally in India, it could prevent 22,000 cervical cancer deaths. If taken globally to the lowest-resource countries, it could prevent around 72,000 deaths in the developing world.